Academic Journal
Recent advances in bioconjugation via CuAAC click reaction: Synthesis and bio-applications.
| Τίτλος: | Recent advances in bioconjugation via CuAAC click reaction: Synthesis and bio-applications. |
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| Συγγραφείς: | Shukla A; Glycochemistry Laboratory, School of Physical Sciences, Jawaharlal Nehru University, New Delhi, 110067, India., Yadav Y; Glycochemistry Laboratory, School of Physical Sciences, Jawaharlal Nehru University, New Delhi, 110067, India., Sagar R; Glycochemistry Laboratory, School of Physical Sciences, Jawaharlal Nehru University, New Delhi, 110067, India. Electronic address: ram.sagar@jnu.ac.in. |
| Πηγή: | Bioorganic chemistry [Bioorg Chem] 2026 Sep 15; Vol. 180, pp. 110229. Date of Electronic Publication: 2026 Jul 06. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE |
| Imprint Name(s): | Publication: Amsterdam : Elsevier Original Publication: New York, London, Academic Press. |
| Ιατρικοί όροι (MeSH): | Alkynes*/chemistry , Copper*/chemistry , Azides*/chemistry , Click Chemistry*, Cycloaddition Reaction ; Humans ; Catalysis ; Molecular Structure |
| Περίληψη: | Click chemistry is a highly reliable and straightforward method for bioconjugation. It exhibits high selectivity and biocompatibility, rendering biorthogonal tagging and regenerative medicine. Its transformative applications in targeted therapy, drug delivery, molecular imaging, and nanotechnology are paving the way for groundbreaking advancements in chemistry and biology. In this review, we discuss the detailed application of Copper-catalysed azide-alkyne cycloaddition (CuAAC), with limited examples of SPAAC, IEDDA, SuFEX, SeNEx and PFEx including recent advances in bioconjugation through the application of bioorthognal methods using click chemistry, focusing on the synthesis of privileged bioconjugates during 2020-2025. Thus, this review highlights the significance of click chemistry as a powerful method for bioconjugation, providing a valuable resource for the scientific community on click chemistry and its applications in biomedical sciences. (Copyright © 2026 Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Bio-imaging; Bio-orthogonal; Bioconjugation; Click chemistry; Triazole |
| Substance Nomenclature: | 0 (Alkynes) 789U1901C5 (Copper) 0 (Azides) |
| Entry Date(s): | Date Created: 20260710 Date Completed: 20260725 Latest Revision: 20260725 |
| Update Code: | 20260725 |
| DOI: | 10.1016/j.bioorg.2026.110229 |
| PMID: | 42430826 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1090-2120 |
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| DOI: | 10.1016/j.bioorg.2026.110229 |