Academic Journal
Natural variation in C. elegans 1-octanol olfactory avoidance behavior.
| Τίτλος: | Natural variation in C. elegans 1-octanol olfactory avoidance behavior. |
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| Συγγραφείς: | Polk EA; Department of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14260, United States., Tanny RE; Department of Biology, Johns Hopkins University, Baltimore, MD 21218, United States., Shaver AO; Department of Biology, Johns Hopkins University, Baltimore, MD 21218, United States., Andersen EC; Department of Biology, Johns Hopkins University, Baltimore, MD 21218, United States., Gokcumen O; Department of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14260, United States., Ferkey DM; Department of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14260, United States. |
| Πηγή: | G3 (Bethesda, Md.) [G3 (Bethesda)] 2026 Oct 07; Vol. 16 (10). |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Oxford University Press Country of Publication: England NLM ID: 101566598 Publication Model: Print Cited Medium: Internet ISSN: 2160-1836 (Electronic) Linking ISSN: 21601836 NLM ISO Abbreviation: G3 (Bethesda) Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2021- : [Oxford] : Oxford University Press Original Publication: Bethesda, MD : Genetics Society of America, 2011- |
| Ιατρικοί όροι (MeSH): | Caenorhabditis elegans*/genetics , Caenorhabditis elegans*/physiology , Caenorhabditis elegans*/drug effects , 1-Octanol*/pharmacology , Smell*/genetics , Behavior, Animal*/drug effects , Avoidance Learning*/drug effects , Genetic Variation*, Animals ; Quantitative Trait Loci ; Genome-Wide Association Study ; Odorants |
| Περίληψη: | The detection of chemical stimuli is a fundamental driver of animal behavior. Odorants and tastants provide essential information about not just food availability and quality, but also about environmental conditions and safety. However, much of what we know about how animals respond to their surroundings comes from the study of a limited number of laboratory-adapted strains of model organisms. In the case of Caenorhabditis elegans, chemosensory research has focused almost exclusively on the N2 strain first isolated in Bristol, England, in 1951, and which has been deemed the wild-type reference for studies of the species since that time. A collection of hundreds of wild C. elegans strains gathered from around the globe and whole-genome sequence data are now available through the Caenorhabditis Natural Diversity Resource. Using these resources, we assessed natural variation in behavioral sensitivity to the aversive odorant 1-octanol. We found that the wild strains either responded similarly to N2 or were less sensitive. No hypersensitive strains were seen among those tested. Using genome-wide association studies we identified a single quantitative trait locus (QTL) on the right arm of chromosome II correlated with diminished behavioral avoidance of 1-octanol and confirmed its role using near-isogenic lines. Building upon our recent report of wild strain taste responses, this study is only the second of this scale to investigate how natural genetic variation shapes C. elegans chemosensory behavior, focusing for the first time on olfaction. (© The Author(s) 2026. Published by Oxford University Press on behalf of The Genetics Society of America.) |
| Grant Information: | IOS-2334104 National Science Foundation |
| Contributed Indexing: | Keywords: C. elegans; 1-octanol; GWAS; avoidance; behavior; olfaction; wild strain |
| Substance Nomenclature: | NV1779205D (1-Octanol) |
| Entry Date(s): | Date Created: 20260709 Date Completed: 20261007 Latest Revision: 20261007 |
| Update Code: | 20261008 |
| DOI: | 10.1093/g3journal/jkag189 |
| PMID: | 42424537 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2160-1836 |
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| DOI: | 10.1093/g3journal/jkag189 |