Academic Journal
Antimicrobial Activity, Mechanism, and Future Prospects of Baicalin as an Antimicrobial Agent and Adjuvant.
| Title: | Antimicrobial Activity, Mechanism, and Future Prospects of Baicalin as an Antimicrobial Agent and Adjuvant. |
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| Authors: | Chen G; Clinical Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Li M; Department of Nuclear Medicine, Yaan People's Hospital, Yaan, China., Zeng Y; School of Public Health, Chengdu Medical College, Chengdu, China., Guo X; West China Hospital of Stomatology, Sichuan University, Chengdu, China., Li C; Clinical Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Xu W; Department of Nuclear Medicine, Yaan People's Hospital, Yaan, China., Wu F; Department of Nuclear Medicine, Yaan People's Hospital, Yaan, China., Yang L; Department of Laboratory Medicine, The People's Hospital of Leshan, Leshan, China., Yang F; Department of Nuclear Medicine, Yaan People's Hospital, Yaan, China., Zheng D; Department of Nuclear Medicine, Yaan People's Hospital, Yaan, China. |
| Source: | Archiv der Pharmazie [Arch Pharm (Weinheim)] 2026 Jun; Vol. 359 (6), pp. e70297. |
| Publication Type: | Journal Article; Review |
| Language: | English |
| Journal Info: | Publisher: Wiley-VCH Verlag GmbH & Co. KGaA Country of Publication: Germany NLM ID: 0330167 Publication Model: Print Cited Medium: Internet ISSN: 1521-4184 (Electronic) Linking ISSN: 03656233 NLM ISO Abbreviation: Arch Pharm (Weinheim) Subsets: MEDLINE |
| Imprint Name(s): | Publication: <2005->: Weinheim Germany : Wiley-VCH Verlag GmbH & Co. KGaA Original Publication: Weinheim, Verlag Chemie GmbH. |
| MeSH Terms: | Flavonoids*/pharmacology , Flavonoids*/chemistry , Flavonoids*/pharmacokinetics , Flavonoids*/isolation & purification , Flavonoids*/administration & dosage , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/pharmacokinetics , Anti-Bacterial Agents*/isolation & purification , Adjuvants, Pharmaceutic*/pharmacology , Bacteria*/drug effects , Anti-Infective Agents*/pharmacology, Biofilms/drug effects ; Scutellaria baicalensis/chemistry ; Humans ; Animals ; Biological Availability ; Microbial Sensitivity Tests |
| Abstract: | Baicalin is a bioactive flavonoid compound extracted from plants of the Scutellaria genus, such as Scutellaria baicalensis, and exhibits a wide range of pharmacological effects. Studies have shown that it has antibacterial activity against a variety of clinically common pathogens. Meanwhile, it can inhibit the development of antimicrobial resistance, thereby enhancing the antibacterial activity of traditional antibiotics. This highlights the potential of baicalin as an antimicrobial agent and antibiotic adjuvant. This review systematically summarizes the antibacterial activity, antibiofilm effects, beneficial properties, and underlying mechanisms of baicalin, both when used alone and in combination with antibiotics, in in vitro and in vivo models. At the same time, the pharmacokinetic properties and cytotoxicity studies of baicalin were also reviewed. Given its relatively low bioavailability in vivo, the development of baicalin-based nanoformulations and other dosage forms has been highlighted as a promising strategy to enhance its bioavailability and expand its potential applications. Finally, this article discusses the limitations and shortcomings of current research and outlines future research directions. We emphasize the need to evaluate the medication strategies, clinical efficacy, and safety of baicalin in the treatment of microbial infections through higher-quality research. This review aims to provide new insights and references for the further development and clinical application of baicalin. (© 2026 Deutsche Pharmazeutische Gesellschaft.) |
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| Grant Information: | 25LHGJ2-12 International Clinical Research Center of Chengdu Medical College |
| Contributed Indexing: | Keywords: antimicrobial mechanism; bacteria; baicalin; biofilm; combined treatment |
| Substance Nomenclature: | 0 (Flavonoids) 347Q89U4M5 (baicalin) 0 (Anti-Bacterial Agents) 0 (Adjuvants, Pharmaceutic) 0 (Anti-Infective Agents) |
| Entry Date(s): | Date Created: 20260709 Date Completed: 20260709 Latest Revision: 20260709 |
| Update Code: | 20260709 |
| DOI: | 10.1002/ardp.70297 |
| PMID: | 42421484 |
| Database: | MEDLINE |
| ISSN: | 1521-4184 |
|---|---|
| DOI: | 10.1002/ardp.70297 |