Academic Journal
Spatial-Photonic Encoding on a Single Fiber: Breaking the Bottleneck in Photoelectrochemical Biosensing for Precision Diagnostics.
| Τίτλος: | Spatial-Photonic Encoding on a Single Fiber: Breaking the Bottleneck in Photoelectrochemical Biosensing for Precision Diagnostics. |
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| Συγγραφείς: | Zou H; Hunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, Central South University, Changsha 410083, P. R. China.; School of Engineering Science, Shandong Xiehe University, Jinan 250107, P. R. China., Bian E; Hunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, Central South University, Changsha 410083, P. R. China., Zuo X; Hunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, Central South University, Changsha 410083, P. R. China., Yan W; State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Beijing 100037, P. R. China., Zhou J; Beijing Anzhen Hospital, Capital Medical University, Beijing 100011, P. R. China., He Z; Department of Cardiovascular, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, P. R. China., Wu W; School of Engineering Science, Shandong Xiehe University, Jinan 250107, P. R. China., Deng C; Hunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, Central South University, Changsha 410083, P. R. China.; National Key Laboratory of Aerospace Physics in Fluids, Mianyang 621000, P. R. China. |
| Πηγή: | Analytical chemistry [Anal Chem] 2026 Jul 21; Vol. 98 (28), pp. 20877-20890. Date of Electronic Publication: 2026 Jul 07. |
| Τύπος έκδοσης: | Journal Article; Research Support, Non-U.S. Gov't |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6882 (Electronic) Linking ISSN: 00032700 NLM ISO Abbreviation: Anal Chem Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Washington, American Chemical Society. |
| Ιατρικοί όροι (MeSH): | Biosensing Techniques*/methods , Biosensing Techniques*/instrumentation , Electrochemical Techniques*/instrumentation , Electrochemical Techniques*/methods , Troponin I*/analysis , Troponin I*/blood , Natriuretic Peptide, Brain*/analysis , Natriuretic Peptide, Brain*/blood , Peptide Fragments*/analysis , Peptide Fragments*/blood , Optical Fibers* , Photons*, Gold/chemistry ; Metal Nanoparticles/chemistry ; Humans ; Microelectrodes ; Photochemical Processes |
| Περίληψη: | Here we present, for the first time, a light-encoded, dual-zone, single optical fiber (Zonal@OF)-based photoelectrochemical (PEC) microelectrode for the simultaneous and spatially resolved quantification of multiple biomarkers. To overcome the limitations of external light sources and rigid electrodes in conventional PEC biosensors, a single optical fiber was precisely etched to create two independent sensing zones (Zone I and Zone II). Each zone was sequentially functionalized with a gold nanoparticle conductive layer, a zone-specific light-harvesting material (BiOI nanoflakes for Zone I; methylene blue for Zone II), and a corresponding target-specific aptamer (for NT-proBNP and cTnI, respectively). The core innovation enables wavelength-resolved operation: upon separate excitation at 450 and 650 nm, the two zones generate distinct, noninterfering photoelectrochemical signals, allowing for the simultaneous, cross-talk-free detection of NT-proBNP and cTnI. The developed Zonal@OF-PEC sensor demonstrates high sensitivity at the pg mL-1 level, excellent specificity. By leveraging self-guided illumination and the miniaturized dimensions of optical fibers, along with achieving spatial-photonic encoding on a single fiber, this work demonstrates the potential of PEC biosensor to be further explored for real-time, multianalyte tracking. This capability bridges a critical gap toward their clinical translation in precision medicine. |
| Substance Nomenclature: | 7440-57-5 (Gold) 0 (Troponin I) 114471-18-0 (Natriuretic Peptide, Brain) 0 (pro-brain natriuretic peptide (1-76)) 0 (Peptide Fragments) |
| Entry Date(s): | Date Created: 20260707 Date Completed: 20260721 Latest Revision: 20260721 |
| Update Code: | 20260721 |
| DOI: | 10.1021/acs.analchem.6c01769 |
| PMID: | 42411579 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1520-6882 |
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| DOI: | 10.1021/acs.analchem.6c01769 |