Flash nanoprecipitation of magnetic particle imaging tracers with tunable performance.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος:	Flash nanoprecipitation of magnetic particle imaging tracers with tunable performance.
Συγγραφείς:	Nozka A; Department of Chemical Engineering, University of Florida, Gainesville, FL 32611, USA. carlos.rinaldi@ufl.edu., Valdés DP; Department of Chemical Engineering, University of Florida, Gainesville, FL 32611, USA. carlos.rinaldi@ufl.edu., Imhoff ED; Department of Chemical Engineering, University of Florida, Gainesville, FL 32611, USA. carlos.rinaldi@ufl.edu., Melnyk A; Department of Chemical Engineering, University of Florida, Gainesville, FL 32611, USA. carlos.rinaldi@ufl.edu., Rinaldi-Ramos CM; Department of Chemical Engineering, University of Florida, Gainesville, FL 32611, USA. carlos.rinaldi@ufl.edu.; J. Crayton Pruitt Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA.
Πηγή:	Nanoscale [Nanoscale] 2026 Aug 06; Vol. 18 (30), pp. 16157-16167. Date of Electronic Publication: 2026 Aug 06.
Τύπος έκδοσης:	Journal Article
Γλώσσα:	English
Στοιχεία περιοδικού:	Publisher: RSC Pub Country of Publication: England NLM ID: 101525249 Publication Model: Electronic Cited Medium: Internet ISSN: 2040-3372 (Electronic) Linking ISSN: 20403364 NLM ISO Abbreviation: Nanoscale Subsets: MEDLINE
Imprint Name(s):	Original Publication: Cambridge, UK : RSC Pub.
Ιατρικοί όροι (MeSH):	Magnetic Particle Imaging/methods , Magnetite Nanoparticles/chemistry , Magnetic Iron Oxide Nanoparticles*/chemistry, Liver/diagnostic imaging ; Liver/metabolism ; Polymers/chemistry ; Contrast Media/chemistry ; Animals ; Mice
Περίληψη:	Magnetic particle imaging (MPI) is a novel biomedical imaging modality where biocompatible magnetic nanoparticle (MNP) tracers produce a quantitative signal for imaging applications like pharmacokinetics studies, blood pooling, cell tracking, and more. Improvements to tracer performance are generally made through the alteration of the synthesis mechanism and post-synthesis surface modification tailored to different applications. However, relying on synthesis alone to modify MPI performance can be difficult and time consuming. This study utilized flash nanoprecipitation, a method of MNP encapsulation, to vary the MPI performance of tracers. Herein, composite nanoparticle tracers were produced by precipitating hydrophobic iron oxide nanoparticles and homopolymer in water and stabilizing them with an amphiphilic block copolymer. By increasing the concentration of homopolymer used in precipitation, composite nanoparticle tracers with a range of physical properties and MPI performances were obtained, until a peak MPI performance was achieved and after which additional homopolymer did not further improve performance. Two pre-clinical applications of this work were demonstrated; the first was an in vivo imaging study and the second was color MPI. Intravenous injections show accumulation of two formulations in the liver and spleen after 24 hours, with MPI performance matching trends previously identified. Color MPI, an application of MPI whereby the signal from two MNP tracers can be separated into the signal contribution from each particle, allows for simultaneous tracking of multiple labelled species. Here, it was demonstrated using a 3D-printed mouse phantom mimicking accumulation of a two-formulation mixture in the liver, and individual particle formulations accumulating in the brain and hind flank tumor. The ratio of particles in each location was determined from the image and were comparable to ground truth values. This work demonstrates the ability of FNP to produce tunable MPI tracers, unlocking a range of applications, including pre-clinical imaging and color MPI.
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Grant Information:	R01 EB031224 United States EB NIBIB NIH HHS
Substance Nomenclature:	0 (Magnetite Nanoparticles) 0 (Polymers) 0 (Contrast Media)
Entry Date(s):	Date Created: 20260707 Date Completed: 20260806 Latest Revision: 20260922
Update Code:	20260922
PubMed Central ID:	PMC13339030
DOI:	10.1039/d6nr01104g
PMID:	42411402
Βάση Δεδομένων:	MEDLINE

Περιγραφή
ISSN:	2040-3372
DOI:	10.1039/d6nr01104g