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Association of 30-second chair stand test performance with exercise intolerance and hospitalization for symptomatic heart failure in type 2 diabetes and stage B heart failure.

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Τίτλος: Association of 30-second chair stand test performance with exercise intolerance and hospitalization for symptomatic heart failure in type 2 diabetes and stage B heart failure.
Συγγραφείς: Sugita Y; Faculty of Health Sciences, Tsukuba University of Technology, Ibaraki, Japan. Electronic address: y.sugita@cc.k.tsukuba-tech.ac.jp., Kudo A; Faculty of Health Sciences, Tsukuba University of Technology, Ibaraki, Japan; Department of Rehabilitation, Kamagaya General Hospital, Chiba, Japan., Arakawa S; Faculty of Health Sciences, Tsukuba University of Technology, Ibaraki, Japan; Department of Rehabilitation, Seibu General Hospital, Saitama, Japan., Sakai S; Faculty of Health Sciences, Tsukuba University of Technology, Ibaraki, Japan.
Πηγή: Journal of cardiology [J Cardiol] 2026 Oct; Vol. 88 (4), pp. 321-328. Date of Electronic Publication: 2026 Jul 06.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8804703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-4738 (Electronic) Linking ISSN: 09145087 NLM ISO Abbreviation: J Cardiol Subsets: MEDLINE
Imprint Name(s): Publication: Amsterdam : Elsevier
Original Publication: Tokyo : Japanese College Of Cardiology
Ιατρικοί όροι (MeSH): Diabetes Mellitus, Type 2*/complications , Diabetes Mellitus, Type 2*/physiopathology , Heart Failure*/physiopathology , Heart Failure*/diagnosis , Heart Failure*/etiology , Heart Failure*/complications , Exercise Tolerance*/physiology , Exercise Test*/methods , Hospitalization*/statistics & numerical data, Humans ; Female ; Male ; Prospective Studies ; Aged ; Oxygen Consumption ; Middle Aged ; Prognosis ; Follow-Up Studies ; Predictive Value of Tests
Περίληψη: Background: Exercise intolerance (EI) predicts hospitalization for symptomatic heart failure (HF) in patients with type 2 diabetes mellitus (T2DM); however, cardiopulmonary exercise testing (CPET) is not always feasible in routine practice. The prognostic value of the 30-second chair stand test (CS30), a simple functional assessment correlated with peak oxygen uptake (peakVO2), remains unclear. We investigated whether the CS30 reflects exercise capacity and predicts hospitalization for symptomatic HF in patients with T2DM and stage B HF.
Methods: A total of 502 outpatients with T2DM and stage B HF were prospectively enrolled. Exercise capacity was assessed using peakVO2 from CPET and functional performance using CS30. EI was defined as peakVO2 ≤80% predicted, and abnormal-CS30 as <18 repetitions for males and <16 for females. Participants were followed for the first hospitalization for symptomatic HF. Associations were assessed using multivariable Cox models, and discrimination using the 5-year time-dependent area under the receiver operating characteristic curve (AUC).
Results: The CS30 performance was significantly associated with peakVO2. Over a median follow-up of 5.1 years, 91 patients were hospitalized for symptomatic HF. Abnormal-CS30 independently predicted hospitalization for symptomatic HF after adjustment for the WATCH-DM score, B-type natriuretic peptide, left ventricular hypertrophy, and atrial fibrillation. Adding the CS30 to resting risk models significantly improved the 5-year AUC, with performance comparable to that of EI.
Conclusions: In patients with T2DM and stage B HF, the CS30 reflected reduced exercise capacity and independently predicted hospitalization for symptomatic HF. Given its simplicity and feasibility, the CS30 may serve as a practical functional marker to complement resting risk models when CPET is unavailable.
(Copyright © 2026 Elsevier Ltd. All rights reserved.)
Competing Interests: Declaration of competing interest None.
Contributed Indexing: Keywords: 30-second chair stand test; Heart failure hospitalization; Heart failure risk stratification; Peak oxygen uptake; Type 2 diabetes mellitus
Entry Date(s): Date Created: 20260706 Date Completed: 20260930 Latest Revision: 20260930
Update Code: 20261001
DOI: 10.1016/j.jjcc.2026.07.003
PMID: 42409310
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1876-4738
DOI:10.1016/j.jjcc.2026.07.003