Academic Journal
Eight-week high-intensity inspiratory muscle training improves cardiac autonomic function in COPD: a randomized controlled trial.
| Τίτλος: | Eight-week high-intensity inspiratory muscle training improves cardiac autonomic function in COPD: a randomized controlled trial. |
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| Συγγραφείς: | Suraprapapich P; Siriraj Vascular Research Center, Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Faculty of Physical Therapy, Mahidol University, Nakhon Pathom, Thailand., Watanapa WB; Siriraj Vascular Research Center, Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand., Dacha S; Department of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand., Ketpan W; Division of Respiratory Disease and Tuberculosis, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand., Yeunyong S; Division of Respiratory Disease and Tuberculosis, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand., Rattanasaengloet K; Division of Respiratory Disease and Tuberculosis, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand., Sathaporn N; Siriraj Vascular Research Center, Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Department of Physical Therapy, School of Integrative Medicine, Mae Fah Luang University, Chiang Rai, Thailand., Chuaychoo B; Division of Respiratory Disease and Tuberculosis, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. Electronic address: benjamas.chu@mahidol.ac.th. |
| Πηγή: | Respiratory medicine [Respir Med] 2026 Sep; Vol. 261, pp. 109027. Date of Electronic Publication: 2026 Jul 06. |
| Τύπος έκδοσης: | Journal Article; Randomized Controlled Trial |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: England NLM ID: 8908438 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3064 (Electronic) Linking ISSN: 09546111 NLM ISO Abbreviation: Respir Med Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2003- : Oxford : Elsevier Original Publication: London : Baillière Tindall, in association with the British Thoracic Society, [c1989- |
| Ιατρικοί όροι (MeSH): | Autonomic Nervous System*/physiopathology , Breathing Exercises*/methods , Breathing Exercises*/statistics & numerical data , Pulmonary Disease, Chronic Obstructive*/physiopathology , Pulmonary Disease, Chronic Obstructive*/rehabilitation , Pulmonary Disease, Chronic Obstructive*/therapy , Respiratory Muscles*/physiopathology, Baroreflex/physiology ; Blood Pressure/physiology ; Dyspnea/physiopathology ; Heart Rate/physiology ; Inhalation/physiology ; Respiratory Therapy/methods ; Respiratory Therapy/statistics & numerical data ; Aged ; Female ; Humans ; Male ; Middle Aged ; Treatment Outcome |
| Περίληψη: | Background: Cardiovascular autonomic dysfunction and respiratory muscle weakness have been detected in patients with COPD. Although low-intensity inspiratory muscle training over 12 weeks increases cardiac parasympathetic (vagal) activity, eight-week programmes at the highest tolerable intensity and their effects on cardiovascular autonomic function remain untested. Methods: Thirty-nine stable COPD patients were randomized to inspiratory muscle training or control. Both received standard care, excluding pulmonary rehabilitation; the training group additionally performed 30 breaths twice daily at the highest tolerable intensity for eight weeks using a tapered flow resistive loading device. Assessments comprised pulmonary and respiratory muscle function, heart rate variability (HRV), blood pressure variability, baroreflex sensitivity, dyspnoea, 6-min walk distance and health status. Thirty-seven participants (training n = 18, control n = 19) completed the protocol. Results: Maximal inspiratory pressure increased by 22.46 ± 15.71 cmH Conclusion: Eight-week highest tolerable intensity inspiratory muscle training enhances cardiovascular autonomic function in COPD through increased parasympathetic and reduced sympathetic activity, and improves functional capacity and health status. (Copyright © 2026 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. The authors declare that there are no conflicts of interest. |
| Entry Date(s): | Date Created: 20260706 Date Completed: 20260812 Latest Revision: 20260903 |
| Update Code: | 20260904 |
| DOI: | 10.1016/j.rmed.2026.109027 |
| PMID: | 42409226 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1532-3064 |
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| DOI: | 10.1016/j.rmed.2026.109027 |