Academic Journal
Dynamics of the systemic inflammatory response surrounding stressors and the association with neuropsychiatric and somatic outcomes.
| Τίτλος: | Dynamics of the systemic inflammatory response surrounding stressors and the association with neuropsychiatric and somatic outcomes. |
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| Συγγραφείς: | Berlot R; Department of Basic & Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 16 De Crespigny Park, London SE5 8AB, UK; Department of Neurology, University Medical Centre Ljubljana, Zaloška 2a, Ljubljana 1000, Slovenia; Faculty of Medicine, University of Ljubljana, Vrazov trg 2, Ljubljana 1000, Slovenia. Electronic address: rok.2.berlot@kcl.ac.uk., Ipavic E; Department of Basic & Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 16 De Crespigny Park, London SE5 8AB, UK; Department of Neurology, University Medical Centre Ljubljana, Zaloška 2a, Ljubljana 1000, Slovenia; Faculty of Medicine, University of Ljubljana, Vrazov trg 2, Ljubljana 1000, Slovenia., Lynch-Kelly K; Neuropsychiatry Research & Education Group, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 16 De Crespigny Park, London SE5 8AB, UK; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 16 De Crespigny Park, London SE5 8AB, UK., Hafeez D; Neuropsychiatry Research & Education Group, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 16 De Crespigny Park, London SE5 8AB, UK; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 16 De Crespigny Park, London SE5 8AB, UK., Nicholson TR; Neuropsychiatry Research & Education Group, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 16 De Crespigny Park, London SE5 8AB, UK., Edwards MJ; Department of Basic & Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 16 De Crespigny Park, London SE5 8AB, UK; Department of Neuropsychiatry, South London and Maudsley NHS Foundation Trust, Denmark Hill, London SE5 8AZ, UK., Pollak TA; Neuropsychiatry Research & Education Group, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 16 De Crespigny Park, London SE5 8AB, UK; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 16 De Crespigny Park, London SE5 8AB, UK. |
| Πηγή: | Brain, behavior, and immunity [Brain Behav Immun] 2026 Nov; Vol. 138, pp. 106893. Date of Electronic Publication: 2026 Jul 06. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8800478 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2139 (Electronic) Linking ISSN: 08891591 NLM ISO Abbreviation: Brain Behav Immun Subsets: MEDLINE |
| Imprint Name(s): | Publication: <2000- > : Amsterdam : Elsevier Original Publication: San Diego : Academic Press, [c1987- |
| Ιατρικοί όροι (MeSH): | Stress, Psychological*/immunology , Stress, Psychological*/complications , Stress, Psychological*/psychology , Inflammation*/immunology , Mental Disorders*/immunology, Leukocytosis/immunology ; Anxiety Disorders/immunology ; Depression/immunology ; Humans ; Female ; Male ; Adult ; Leukocyte Count ; Middle Aged |
| Περίληψη: | Acute and chronic stressors contribute to neuropsychiatric disorders. However, the role of inflammatory dynamics around stress exposure remains unclear. Using TriNetX, an international electronic health records database, we examined how systemic inflammatory activity and its temporal dynamics relate to risk of mental illness and somatic symptoms. We compared 44,904 individuals with records of accidents and leukocytosis in the surrounding period with matched individuals with normal leukocyte counts, and performed analogous comparisons for socioeconomic and psychosocial stressors in cohorts of 100,855 individuals with leukocytosis and matched controls. To contrast dynamic with static inflammatory responses, we compared cohorts exhibiting leukocyte count changes with those maintaining persistently normal or elevated counts around stressor exposure. Incidence of psychiatric and somatic symptom diagnoses were evaluated within two years of the stressor. Following acute stressors, leukocytosis (compared with normal leukocyte counts) was associated with lower rates of anxiety disorders (Odds Ratio 0.88, 95% Confidence Interval 0.83-0.93), depression (0.92, 0.86-0.98), cognitive symptoms (0.86, 0.81-0.92) and several somatic symptoms, with similar reductions in anxiety (0.92, 0.88-0.95) and depression (0.92, 0.89-0.96) observed after chronic stressors. A dynamic inflammatory response was associated with the most favourable outcomes, with lower rates of anxiety, depression, cognitive difficulties, fatigue, and pain-related symptoms compared to persistently lower or higher inflammation, and lower rates of functional neurological disorder compared to low inflammation. Our findings suggest that patterns of inflammatory response to stressors are associated with diverse mental health and somatic outcomes, with transient immune activation showing a more favourable outcome profile. (Copyright © 2026 The Authors. Published by Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: R.B. is supported by the Slovenian Research and Innovation Agency as a member of the research programme Medical Physics (P1-0389). E.I., K.L.K. and D.H. declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. T.R.N. does medical expert reporting in personal injury and clinical negligence cases, including in cases of FND. He has received financial support for lectures from the FND Society (FNDS). He receives royalties from CRC Press for The Pocket Prescriber textbook series. He also has received grant funding, including for studies related to FND, from the UK National Institute for Health and Care Research (NIHR) and the Medical Research Council (MRC). He is co-chair of the FNDS patient liaison committee and on the medical advisory boards of the charities FND Hope UK and FND Action, and a trustee of FND Action. M.J.E. does medical expert reporting in personal injury and clinical negligence cases, has shares in Brain & Mind, which provides neuropsychiatric and neurological rehabilitation in the independent medical sector, has received financial support for lectures from the International Parkinson’s and Movement Disorders Society and the FND Society (FNDS), receives royalties from Oxford University Press for his book, The Oxford Specialist Handbook of Parkinson’s Disease and Other Movement Disorder, has received honoraria for medical advice to Teva Pharmaceuticals and educational events, receives grant funding from the National Institute for Health and Care Research (NIHR), is the deputy editor of the European Journal of Neurology, and is on the medical advisory boards of the charities FND Hope and the British Association of Performing Arts Medicine. T.A.P. does medical expert reporting in personal injury and clinical negligence cases, including in cases of FND. He has received consultancy fees from Arialys Therapeutics. |
| Contributed Indexing: | Keywords: Accidents; Immune resilience; Inflammatory dynamics; Interface disorders; Neuroimmunology; Psychiatricoutcomes; Psychosocial stressors; Risk factors; Systemic inflammation; TriNetX |
| Entry Date(s): | Date Created: 20260706 Date Completed: 20261009 Latest Revision: 20261009 |
| Update Code: | 20261010 |
| DOI: | 10.1016/j.bbi.2026.106893 |
| PMID: | 42409181 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1090-2139 |
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| DOI: | 10.1016/j.bbi.2026.106893 |