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Composite Dissolvable Microneedle-Enabled Local High-Dose Delivery of Endogenous Thiols for Efficient Allergic Dermatitis Treatment.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Composite Dissolvable Microneedle-Enabled Local High-Dose Delivery of Endogenous Thiols for Efficient Allergic Dermatitis Treatment.
Συγγραφείς: Wang L; State Key Laboratory of Flexible Electronics (LoFE) & Institute of Advanced Materials (IAM), School of Flexible Electronics (Future Technologies), Nanjing Tech University (Nanjing Tech), Nanjing, China., Fang Z; State Key Laboratory of Flexible Electronics (LoFE) & Institute of Advanced Materials (IAM), School of Flexible Electronics (Future Technologies), Nanjing Tech University (Nanjing Tech), Nanjing, China., Wu Z; State Key Laboratory of Flexible Electronics (LoFE) & Institute of Advanced Materials (IAM), School of Flexible Electronics (Future Technologies), Nanjing Tech University (Nanjing Tech), Nanjing, China., Wang W; State Key Laboratory of Flexible Electronics (LoFE) & Institute of Advanced Materials (IAM), School of Flexible Electronics (Future Technologies), Nanjing Tech University (Nanjing Tech), Nanjing, China., Li X; State Key Laboratory of Flexible Electronics (LoFE) & Institute of Advanced Materials (IAM), School of Flexible Electronics (Future Technologies), Nanjing Tech University (Nanjing Tech), Nanjing, China., Shi X; State Key Laboratory of Flexible Electronics (LoFE) & Institute of Advanced Materials (IAM), School of Flexible Electronics (Future Technologies), Nanjing Tech University (Nanjing Tech), Nanjing, China., Lv L; State Key Laboratory of Flexible Electronics (LoFE) & Institute of Advanced Materials (IAM), School of Flexible Electronics (Future Technologies), Nanjing Tech University (Nanjing Tech), Nanjing, China., Lu X; State Key Laboratory of Flexible Electronics (LoFE) & Institute of Advanced Materials (IAM), School of Flexible Electronics (Future Technologies), Nanjing Tech University (Nanjing Tech), Nanjing, China., Li J; State Key Laboratory of Flexible Electronics (LoFE) & Institute of Advanced Materials (IAM), School of Flexible Electronics (Future Technologies), Nanjing Tech University (Nanjing Tech), Nanjing, China.
Πηγή: Chembiochem : a European journal of chemical biology [Chembiochem] 2026 Jul 14; Vol. 27 (13), pp. e70455.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 100937360 Publication Model: Print Cited Medium: Internet ISSN: 1439-7633 (Electronic) Linking ISSN: 14394227 NLM ISO Abbreviation: Chembiochem Subsets: MEDLINE
Imprint Name(s): Original Publication: Weinheim, Germany : Wiley-VCH Verlag, c2000-
Ιατρικοί όροι (MeSH): Cysteine*/administration & dosage , Cysteine*/chemistry , Cysteine*/therapeutic use , Sulfhydryl Compounds*/administration & dosage , Sulfhydryl Compounds*/chemistry , Dermatitis, Allergic Contact*/drug therapy , Drug Delivery Systems*, Hyaluronic Acid/chemistry ; Animals ; Microneedle Drug Delivery ; Mice ; Female ; Needles ; Humans
Περίληψη: Allergic dermatitis (AD) requires long-term management, yet conventional systemic therapies are frequently limited by adverse effects and inadequate lesion-specific delivery. Herein, we report a mechanically reinforced composite dissolvable microneedle (MN) patch (L-Cys@HAMN) for localized endogenous thiol delivery in AD treatment. The patch consists of L-cysteine-loaded hyaluronic acid (HA) microneedle tips integrated with an elastic poly(n-butyl acrylate) (PBA) backing layer, enabling efficient force transmission and consistent skin penetration while minimizing structural deformation. Upon insertion, the dissolvable MN tips rapidly release L-cysteine into the viable epidermis, where it is enzymatically converted into hydrogen sulfide (H2S) to suppress inflammatory responses. In vitro studies demonstrated significant downregulation of proinflammatory cytokines, including TNF-α and IL-6. In a passive cutaneous anaphylaxis mouse model, L-Cys@HAMN markedly alleviated inflammatory infiltration and reduced local inflammatory burden compared with control treatments. In addition, the HA-based matrix provided auxiliary moisturizing and barrier-supporting effects. Collectively, this work presents a mechanically robust and therapeutically effective MN platform for localized endogenous thiol delivery and offers a promising strategy for AD management.
(© 2026 Wiley‐VCH GmbH.)
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Grant Information: 22575119 National Natural Science Foundation of China; BK20251860 Basic Research Program of Jiangsu Province
Contributed Indexing: Keywords: allergic dermatitis; dissolvable microneedle; endogenous thiols; hydrogen sulfide
Substance Nomenclature: K848JZ4886 (Cysteine)
0 (Sulfhydryl Compounds)
9004-61-9 (Hyaluronic Acid)
Entry Date(s): Date Created: 20260706 Date Completed: 20260706 Latest Revision: 20260706
Update Code: 20260706
DOI: 10.1002/cbic.70455
PMID: 42405459
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1439-7633
DOI:10.1002/cbic.70455