Academic Journal
Resting-state EEG reveals slowing and altered functional connectivity in children and young adults with severe chronic kidney disease.
| Τίτλος: | Resting-state EEG reveals slowing and altered functional connectivity in children and young adults with severe chronic kidney disease. |
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| Συγγραφείς: | Lijdsman S; Emma Children's Hospital, Amsterdam University Medical Centers (Amsterdam UMC), University of Amsterdam, Psychosocial Department, Amsterdam, the Netherlands, G8-136, PO Box 22660, 1100, DD, Amsterdam, the Netherlands.; Amsterdam Reproduction and Development research institute, Amsterdam, the Netherlands., Königs M; Amsterdam Reproduction and Development research institute, Amsterdam, the Netherlands.; Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Emma Neuroscience Group, Department of Pediatrics, Amsterdam, the Netherlands., van Sandwijk MS; Amsterdam UMC, University of Amsterdam, Department of Nephrology, Amsterdam, the Netherlands.; Amsterdam institute for Immunology and Infectious disease, Amsterdam, the Netherlands.; Dianet Dialysis Centre, Amsterdam, the Netherlands., Bouts AH; Amsterdam Reproduction and Development research institute, Amsterdam, the Netherlands.; Emma Children's Hospital, Amsterdam University Medical Center (Amsterdam UMC), University of Amsterdam, Department of Pediatric Nephrology, Amsterdam, the Netherlands., van Hoeck K; Department of Pediatrics, University Hospital Antwerp, Belgium., de Jong H; Department of Pediatrics, Sophia Children's Hospital, Erasmus MC, Rotterdam, the Netherlands., Bruining H; Child and Adolescent Psychiatry and Psychosocial Care, Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; N=You Neurodevelopmental Precision Center, Amsterdam Neuroscience, Amsterdam Reproduction and Development, Amsterdam UMC, Amsterdam, the Netherlands.; Levvel, Center for Child and Adolescent Psychiatry, Amsterdam, the Netherlands., Bemelman FJ; Amsterdam UMC, University of Amsterdam, Department of Nephrology, Amsterdam, the Netherlands.; Amsterdam institute for Immunology and Infectious disease, Amsterdam, the Netherlands., van Rootselaar AF; Dept. of Neurology and Clinical Neurophysiology, University of Amsterdam, Amsterdam, UMC, the Netherlands., Oostrom KJ; Emma Children's Hospital, Amsterdam University Medical Centers (Amsterdam UMC), University of Amsterdam, Psychosocial Department, Amsterdam, the Netherlands, G8-136, PO Box 22660, 1100, DD, Amsterdam, the Netherlands.; Amsterdam Reproduction and Development research institute, Amsterdam, the Netherlands., Groothoff JW; Amsterdam Reproduction and Development research institute, Amsterdam, the Netherlands.; Emma Children's Hospital, Amsterdam University Medical Center (Amsterdam UMC), University of Amsterdam, Department of Pediatric Nephrology, Amsterdam, the Netherlands., Bosman CA; Cognitive and Systems Neuroscience Group, Swameerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, the Netherlands.; Amsterdam Brain and Cognition, University of Amsterdam, Amsterdam, the Netherlands. |
| Πηγή: | Clinical neurophysiology practice [Clin Neurophysiol Pract] 2026 Jun 12; Vol. 11, pp. 528-537. Date of Electronic Publication: 2026 Jun 12 (Print Publication: 2026). |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101684308 Publication Model: eCollection Cited Medium: Internet ISSN: 2467-981X (Electronic) Linking ISSN: 2467981X NLM ISO Abbreviation: Clin Neurophysiol Pract Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam : Elsevier, [2016]- |
| Περίληψη: | Objective: Explore associations between quantitative markers of resting-state electroencephalography (EEG), severe chronic kidney disease (CKD), and neurocognition in children and young adults. Methods: We included 25 patients with CKD with an estimated glomerular filtration rate < 30 ml/min/1.73m2 aged 8-30 years, on different treatment modalities (pre-dialysis [n = 6], dialysis [n = 8], transplanted [n = 11]). EEG parameters of power spectrum analysis and functional connectivity were obtained using the Fourier transformation and amplitude envelope correlation (AEC) analysis, respectively. Neurocognition was measured using a comprehensive neurocognitive test battery. Mixed model analyses assessed relations between CKD parameters, EEG parameters and neurocognitive functions. Results: A longer time on dialysis in the past was significantly related to a higher delta and lower alpha power, which related to poorer Processing Speed and Working Memory. Patients on kidney replacement therapy had significantly higher delta AEC than pre-dialysis patients. A higher eGFR after transplantation was related to a higher delta AEC. Delta AEC was not related to neurocognitive performance. Conclusion: Abnormal high delta power may be indicative of clinically apparent encephalopathy in young patients with kidney failure. The role of increased functional connectivity as potential compensatory mechanism should be further explored. Significance: Minimizing dialysis-time by early transplantation may be advantageous in the prevention of encephalopathy in young CKD patients. (© 2026 The Authors.) |
| Competing Interests: | The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
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| Entry Date(s): | Date Created: 20260706 Date Completed: 20260706 Latest Revision: 20260813 |
| Update Code: | 20260814 |
| PubMed Central ID: | PMC13330574 |
| DOI: | 10.1016/j.cnp.2026.06.002 |
| PMID: | 42404805 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2467-981X |
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| DOI: | 10.1016/j.cnp.2026.06.002 |