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Genetic mutations and synaptic dysfunctions in social interaction disorders: insights from invertebrate models to humans.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Genetic mutations and synaptic dysfunctions in social interaction disorders: insights from invertebrate models to humans.
Συγγραφείς: Anadu VE; Laboratory for Experimental and Translational Neurobiology, University of Medical Sciences, Ondo City, 351101, Ondo State, Nigeria. ana234193@unimed.edu.ng.; Department of Anatomy, Faculty of Basic Medical Sciences, University of Medical Sciences, Ondo City, 351101, Ondo State, Nigeria. ana234193@unimed.edu.ng., Oyerinde TO; Laboratory for Experimental and Translational Neurobiology, University of Medical Sciences, Ondo City, 351101, Ondo State, Nigeria.; Department of Anatomy, Faculty of Basic Medical Sciences, University of Medical Sciences, Ondo City, 351101, Ondo State, Nigeria., Gbayisomore TJ; Laboratory for Experimental and Translational Neurobiology, University of Medical Sciences, Ondo City, 351101, Ondo State, Nigeria.; Department of Anatomy, Faculty of Basic Medical Sciences, University of Medical Sciences, Ondo City, 351101, Ondo State, Nigeria., Oyeniran DA; Laboratory for Experimental and Translational Neurobiology, University of Medical Sciences, Ondo City, 351101, Ondo State, Nigeria.; Department of Anatomy, Faculty of Basic Medical Sciences, University of Medical Sciences, Ondo City, 351101, Ondo State, Nigeria., Adeniran FT; Laboratory for Experimental and Translational Neurobiology, University of Medical Sciences, Ondo City, 351101, Ondo State, Nigeria.; Department of Anatomy, Faculty of Basic Medical Sciences, University of Medical Sciences, Ondo City, 351101, Ondo State, Nigeria., Ijomone OK; Laboratory for Experimental and Translational Neurobiology, University of Medical Sciences, Ondo City, 351101, Ondo State, Nigeria.; Department of Anatomy, Faculty of Basic Medical Sciences, University of Medical Sciences, Ondo City, 351101, Ondo State, Nigeria., Ijomone OM; Laboratory for Experimental and Translational Neurobiology, University of Medical Sciences, Ondo City, 351101, Ondo State, Nigeria. omijomone@unimed.edu.ng.; Department of Anatomy, Faculty of Basic Medical Sciences, University of Medical Sciences, Ondo City, 351101, Ondo State, Nigeria. omijomone@unimed.edu.ng.; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA. omijomone@unimed.edu.ng.
Πηγή: Metabolic brain disease [Metab Brain Dis] 2026 Jul 04; Vol. 41 (1). Date of Electronic Publication: 2026 Jul 04.
Τύπος έκδοσης: Journal Article; Review; Research Support, N.I.H., Extramural
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Springer Country of Publication: United States NLM ID: 8610370 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-7365 (Electronic) Linking ISSN: 08857490 NLM ISO Abbreviation: Metab Brain Dis Subsets: MEDLINE
Imprint Name(s): Publication: 2005- : Amsterdam : Springer
Original Publication: New York : Plenum, c1986-
Ιατρικοί όροι (MeSH): Synapses*/genetics , Synapses*/metabolism , Mutation*/genetics , Social Interaction*, Animals ; Humans ; Disease Models, Animal ; Social Behavior ; Caenorhabditis elegans
Περίληψη: Abnormal social interactions are key features of various neurodevelopmental and neuropsychiatric disorders, including autism, attention-deficit/hyperactivity disorder, and schizophrenia. Social interaction behaviours are highly conserved and have evolved across species. Studying social behaviours is crucial as it determines an organism's survival, development, and reproduction. Research over the years has demonstrated how genetic mutations influence synaptic architecture and function, revealing their contributions to these social abnormalities. Furthermore, specific genes, known as cell adhesion molecules (CAM), play important roles in the formation, maturation, and functioning of the synapses, and mutations in these genes alter normal synaptic formation and functioning, consequently disrupting behavioural outcomes. In biological systems, normal synaptogenesis has functional implications for social behaviours necessary for social bonding and cooperation. This review integrates findings from studies across various model organisms-including the C. elegans, Drosophila melanogaster, Zebrafish, and rodents- to elucidate how alterations in synaptic function disrupt social interaction. We extensively discuss how mutations in CAM genes alter key conserved synaptic pathways, leading to neurochemical alterations that contribute to social deficits common in neurodevelopmental disorders, as well as therapeutic strategies inspired by animal studies, including the use of drugs and gene therapies in the management and treatment of the symptoms observed in social interaction disorders.
(© 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Competing Interests: Declarations. Competing interests: The authors declare no competing interests.
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Grant Information: NIH-FIC K43TW011920 United States TW FIC NIH HHS
Contributed Indexing: Keywords: Caenorhabditis elegans; Cell adhesion molecules; Mutation; Social interaction; Synapses
Entry Date(s): Date Created: 20260704 Date Completed: 20260704 Latest Revision: 20260720
Update Code: 20260720
DOI: 10.1007/s11011-026-01921-w
PMID: 42400695
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1573-7365
DOI:10.1007/s11011-026-01921-w