Academic Journal
The longitudinal decrease in exercise tolerance and disease progression in mild-to-moderate COPD.
| Τίτλος: | The longitudinal decrease in exercise tolerance and disease progression in mild-to-moderate COPD. |
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| Συγγραφείς: | Wan Q; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Diseases & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health & The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Deng Z; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Diseases & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health & The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Wu F; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Diseases & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health & The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Zhou K; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Diseases & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health & The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Tang G; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Diseases & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health & The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Huang S; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Diseases & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health & The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Guangzhou National Laboratory, Guangzhou, China., Dai C; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Diseases & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health & The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Lu L; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Diseases & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health & The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Wu X; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Diseases & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health & The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Guangzhou National Laboratory, Guangzhou, China., Cai G; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Diseases & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health & The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Wu F; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Diseases & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health & The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Wang X; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Diseases & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health & The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Guangzhou National Laboratory, Guangzhou, China., Lin J; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Diseases & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health & The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Guangzhou National Laboratory, Guangzhou, China., Xu B; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Diseases & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health & The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Li S; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Diseases & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health & The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Yang C; Department of Pulmonary and Critical Care Medicine, Wengyuan People's Hospital, Shaoguan, China., Chen S; Medical Imaging Center, Wengyuan People's Hospital, Shaoguan, China., Huang Y; Lianping County People's Hospital, Heyuan, China., Yu S; Lianping County Second People's Hospital, Heyuan, China., Zhou Y; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Diseases & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health & The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Guangzhou National Laboratory, Guangzhou, China. Electronic address: zhouyumin410@126.com., Ran P; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Diseases & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health & The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Guangzhou National Laboratory, Guangzhou, China. Electronic address: pxran@gzhmu.edu.cn. |
| Συλλογικό Έργο: | ECOPD Study Investigators |
| Πηγή: | Respiratory medicine [Respir Med] 2026 Sep; Vol. 261, pp. 109021. Date of Electronic Publication: 2026 Jul 02. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: England NLM ID: 8908438 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3064 (Electronic) Linking ISSN: 09546111 NLM ISO Abbreviation: Respir Med Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2003- : Oxford : Elsevier Original Publication: London : Baillière Tindall, in association with the British Thoracic Society, [c1989- |
| Ιατρικοί όροι (MeSH): | Exercise Tolerance*/physiology , Pulmonary Disease, Chronic Obstructive*/physiopathology , Pulmonary Disease, Chronic Obstructive*/diagnosis, China/epidemiology ; Humans ; Disease Progression ; Male ; Female ; Prospective Studies ; Exercise Test ; Aged ; Middle Aged ; Longitudinal Studies ; Spirometry ; Forced Expiratory Volume ; Severity of Illness Index ; Tomography, X-Ray Computed |
| Περίληψη: | Introduction: Exercise intolerance serves as a prognostic marker for poor respiratory outcomes in mild-to-moderate COPD. However, the longitudinal change in exercise tolerance and its association with disease progression remains unknown. We aimed to explore the association of longitudinal change in exercise tolerance with disease progression in mild-to-moderate COPD. Methods: This community-based, prospective cohort study was conducted in China from 2019 to 2024. The participants completed baseline questionnaires, spirometry, chest computed tomography, and cardiopulmonary exercise testing (CPET), and underwent annual acute exacerbation assessment and spirometry over 3 years. Participants were categorized by the longitudinal change in peak oxygen uptake from baseline to 3 years into groups with non-declined or declined exercise tolerance. Results: Overall, 213 participants with mild-to-moderate COPD who completed baseline and 3-year CPET were analyzed, including 131 (61.5%) with exercise tolerance decline. For every 5% longitudinal decrease in exercise tolerance, there was greater progression of air trapping (adjusted difference = 0.18%/year, 95% CI 0.01-0.34, P = 0.033) and a faster decline in postbronchodilator FEV Conclusions: The longitudinal decrease in exercise tolerance over 3 years was associated with accelerated lung function decline and air trapping progression, suggesting it may be a marker associated with disease progression in mild-to-moderate COPD. (Copyright © 2026 Elsevier Ltd. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Cardiopulmonary exercise testing; Chest radiographic structure; Exercise tolerance; Longitudinal analysis; Lung function decline |
| Entry Date(s): | Date Created: 20260702 Date Completed: 20260812 Latest Revision: 20260812 |
| Update Code: | 20260813 |
| DOI: | 10.1016/j.rmed.2026.109021 |
| PMID: | 42392279 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1532-3064 |
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| DOI: | 10.1016/j.rmed.2026.109021 |