Academic Journal
Autonomic dysfunction in systemic lupus erythematosus and systemic sclerosis.
| Τίτλος: | Autonomic dysfunction in systemic lupus erythematosus and systemic sclerosis. |
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| Συγγραφείς: | Avcu A; Department of Internal Medicine, Division of Rheumatology, Marmara University School of Medicine, Istanbul, Türkiye., Baltaci ZH; Marmara University School of Medicine, Istanbul, Türkiye., Ergin DD; Marmara University School of Medicine, Istanbul, Türkiye., Asicioglu E; Department of Internal Medicine, Division of Nephrology, Marmara University School of Medicine, Istanbul, Türkiye., Direskeneli H; Department of Internal Medicine, Division of Rheumatology, Marmara University School of Medicine, Istanbul, Türkiye., Alibaz-Oner F; Department of Internal Medicine, Division of Rheumatology, Marmara University School of Medicine, Istanbul, Türkiye. |
| Πηγή: | Lupus [Lupus] 2026 Oct; Vol. 35 (11), pp. 1166-1174. Date of Electronic Publication: 2026 Jul 02. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: SAGE Publications Country of Publication: England NLM ID: 9204265 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-0962 (Electronic) Linking ISSN: 09612033 NLM ISO Abbreviation: Lupus Subsets: MEDLINE |
| Imprint Name(s): | Publication: London : SAGE Publications Original Publication: Houndmills, Basingstoke, Hampshire, UK : Scientific & Medical Division, Macmillan Press Ltd., c1991- |
| Ιατρικοί όροι (MeSH): | Scleroderma, Systemic*/complications , Scleroderma, Systemic*/physiopathology , Lupus Erythematosus, Systemic*/complications , Lupus Erythematosus, Systemic*/physiopathology , Autonomic Nervous System Diseases*/etiology , Autonomic Nervous System Diseases*/diagnosis , Autonomic Nervous System Diseases*/physiopathology , Autonomic Nervous System*/physiopathology, Humans ; Female ; Cross-Sectional Studies ; Male ; Adult ; Middle Aged ; Symptom Burden ; Case-Control Studies ; Severity of Illness Index |
| Περίληψη: | Background and ObjectiveAutonomic dysfunction may arise in chronic systemic diseases, including autoimmune connective tissue disorders. This study aimed to quantify autonomic symptom burden in patients with systemic lupus erythematosus (SLE) and systemic sclerosis (SSc), examine clinical correlates, and compare results with controls without autoimmune disease.MethodsThis cross-sectional study included 50 SLE patients, 50 SSc patients, and 35 controls. Clinical and demographic characteristics were collected during visits. Autonomic symptom burden was assessed using the Composite Autonomic Symptom Score-31 (COMPASS-31). COMPASS-31 total and subdomain scores were examined across groups and within disease groups according to clinical and serological variables. A post-hoc COMPASS-31 score >32.5 was used to define high autonomic symptom burden.ResultsMedian total COMPASS-31 scores differed across groups and were higher in both SLE and SSc than in controls (15.43 and 20.53 vs 9.03; p = 0.001). Compared with SLE, SSc had higher orthostatic and vasomotor symptom burden. Using COMPASS-31 > 32.5, high autonomic symptom burden was present in 7/50 (14%) SLE and 13/50 (26%) SSc patients, while none of the controls exceeded the cut-off. In multivariable models, serositis and joint involvement predicted high symptom burden in SLE, whereas clinically significant gastrointestinal involvement and musculoskeletal involvement were independent predictors in SSc. After adjustment for age, sex, and comorbidity, total COMPASS-31 remained higher than in controls in both SLE (β = 7.01; p = 0.013) and SSc (β = 11.24; p < 0.001).ConclusionAutonomic symptom burden appears to be higher in patients with SLE and SSc than in controls. The subgroup differences suggest that autonomic symptoms may cluster with specific organ involvement. COMPASS-31 may be a practical screening tool to identify patients who could benefit from further objective autonomic evaluation. Routine, structured assessment may support timely recognition and management of autonomic symptoms in clinical practice. |
| Competing Interests: | Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. |
| Contributed Indexing: | Keywords: COMPASS-31; autonomic symptom burden; systemic lupus erythematosus; systemic sclerosis |
| Entry Date(s): | Date Created: 20260702 Date Completed: 20260910 Latest Revision: 20260910 |
| Update Code: | 20260910 |
| DOI: | 10.1177/09612033261466750 |
| PMID: | 42389834 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1477-0962 |
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| DOI: | 10.1177/09612033261466750 |