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Sensing Underwater: Diversifying Selection, Convergent Evolution and Inactivation in Sensory Receptors' Genes of Aquatic Mammals.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Sensing Underwater: Diversifying Selection, Convergent Evolution and Inactivation in Sensory Receptors' Genes of Aquatic Mammals.
Συγγραφείς: Lein-Borba AL; Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas, Campinas, SP, Brazil. analuizaclein@gmail.com., Selleghin-Veiga G; Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas, Campinas, SP, Brazil., Daros B; Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas, Campinas, SP, Brazil., Magpali L; Department of Biology, Dalhousie University, Halifax, NS, Canada., Nery MF; Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas, Campinas, SP, Brazil. marinery@unicamp.br.
Πηγή: Journal of molecular evolution [J Mol Evol] 2026 Aug; Vol. 94 (4), pp. 629-654. Date of Electronic Publication: 2026 Jul 01.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0360051 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1432 (Electronic) Linking ISSN: 00222844 NLM ISO Abbreviation: J Mol Evol Subsets: MEDLINE
Imprint Name(s): Original Publication: Berlin, New York, Springer-Verlag.
Ιατρικοί όροι (MeSH): Transient Receptor Potential Channels*/genetics , Cetacea*/genetics , Evolution, Molecular* , Selection, Genetic*, Sirenia/genetics ; Mammals/genetics ; Animals ; Phylogeny ; Amino Acid Substitution ; Amino Acid Sequence
Περίληψη: Cetaceans and sirenians independently transitioned from land to water, evolving unique and convergent sensory adaptations shaped by aquatic environments. Among sensory receptors, the Transient Receptor Potential (TRP) channel superfamily is central to thermo-, chemo-, and mechanosensation, but its evolutionary history in fully aquatic mammals remains poorly characterized. Here, we investigated the molecular evolution of TRP channels in these lineages. Orthology and phylogenetic relationships were inferred using Maximum Likelihood and Bayesian approaches. Signals of positive selection and molecular convergence were evaluated with codon and amino acid models. Amino acid substitutions, protein structure, and stability were assessed using 3D protein modeling. Our analyses reveal accelerated evolutionary rates in aquatic mammals, including multiple positively selected sites, lineage-specific amino acid substitutions, and convergent evolution across cetaceans and sirenians. Protein-level assessments identified substitutions with potential functional consequences, and evidence of pseudogenization was detected in cetacean PKD1L3, PKD2L1, TRPA1, and TRPM5, in contrast to intact copies in sirenians. These patterns suggest lineage-specific sensory trajectories, including reduced chemosensory repertoires in cetaceans, conservation of taste-related genes in sirenians, and adaptations in somatosensory associated genes that reflect both convergent requirements of fully underwater living and distinct aquatic environments. Overall, our findings advance understanding of the molecular mechanisms underlying sensory evolution during the land-to-water transition in mammals.
(© 2026. The Author(s).)
Competing Interests: Declarations. Conflict of interest: The authors have no competing interests to declare that are relevant to the content of this article.
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Contributed Indexing: Keywords: Aquatic mammals; Bioinformatics; Evolutionary genetics; Sensory ecology; Transient receptor potential channels
Substance Nomenclature: 0 (Transient Receptor Potential Channels)
Entry Date(s): Date Created: 20260630 Date Completed: 20260803 Latest Revision: 20260813
Update Code: 20260814
PubMed Central ID: PMC13433407
DOI: 10.1007/s00239-026-10327-2
PMID: 42380302
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1432-1432
DOI:10.1007/s00239-026-10327-2