Academic Journal
A computational model of chemically- and mechanically-induced thrombus formation in cerebral aneurysms.
| Τίτλος: | A computational model of chemically- and mechanically-induced thrombus formation in cerebral aneurysms. |
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| Συγγραφείς: | Cardillo G; LadHyX, CNRS, Ecole Polytechnique, Institut Polytechnique de Paris, Avenue Bequerel, Palaiseau, 91120, France., Pouponneau P; Artedrone, 14 rue Jean Antoine de BaÏf, Paris, 75013, France., Barakat AI; LadHyX, CNRS, Ecole Polytechnique, Institut Polytechnique de Paris, Avenue Bequerel, Palaiseau, 91120, France. Electronic address: abdul.barakat@polytechnique.edu. |
| Πηγή: | Computers in biology and medicine [Comput Biol Med] 2026 Aug 15; Vol. 213, pp. 111829. Date of Electronic Publication: 2026 Jun 30. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: United States NLM ID: 1250250 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0534 (Electronic) Linking ISSN: 00104825 NLM ISO Abbreviation: Comput Biol Med Subsets: MEDLINE |
| Imprint Name(s): | Publication: New York : Elsevier Original Publication: New York, Pergamon Press. |
| Ιατρικοί όροι (MeSH): | Intracranial Aneurysm*/physiopathology , Intracranial Aneurysm*/pathology , Thrombosis*/physiopathology , Models, Cardiovascular* , Computer Simulation*, Fibrin/metabolism ; Humans ; Stress, Mechanical |
| Περίληψη: | Thrombosis, the process of pathological blood clot formation, is a major consideration in the development of cardiovascular diseases and in the design of endovascular devices. Thrombosis is governed by both biochemical and mechanical considerations. Experimental evidence suggests that changes in blood shear rate, i.e., spatial shear gradients, play a critical role in thrombogenesis by controlling the process of platelet aggregation. In light of the above, understanding and predicting thrombus onset and growth in various physiological and pathological settings requires accounting for blood shear changes. The main goal of the current work is to create a comprehensive computational model of chemically- and mechanically-induced thrombus formation that accounts for the effects of shear gradients and extends our previous framework. Relative to our previous modeling, the current model was improved by including the non-Newtonian rheological blood behavior, fibrin fiber generation, and the local increase in fluid viscosity associated with thrombus formation. The model was applied to the specific case of cerebral aneurysms, and the results were consistent with experimental data of thrombus formation in two idealized aneurysm geometries, suggesting the model's ability to produce thrombus spatial and temporal profiles that are consistent with experimental observations. An important finding is that thrombus formation is driven by spatial shear gradients, while subsequent thrombus growth is governed by both mechanical and chemical factors. We believe that the current model constitutes a robust tool for the evaluation of thrombus evolution in scenarios of blood flow disturbance and for the optimization of the cardiovascular device design flow path. (Copyright © 2026 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Cerebral aneurysms; Fibrin generation; Platelet aggregation; Shear gradients; Thrombus formation |
| Substance Nomenclature: | 9001-31-4 (Fibrin) |
| Entry Date(s): | Date Created: 20260630 Date Completed: 20260722 Latest Revision: 20260722 |
| Update Code: | 20260723 |
| DOI: | 10.1016/j.compbiomed.2026.111829 |
| PMID: | 42379034 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1879-0534 |
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| DOI: | 10.1016/j.compbiomed.2026.111829 |