Academic Journal
Bioactive 13,28-oxidooleanane-type saponins from Measa kamerunensis Merk.
| Τίτλος: | Bioactive 13,28-oxidooleanane-type saponins from Measa kamerunensis Merk. |
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| Συγγραφείς: | Tchinda AT; Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon; Department of Chemistry, Faculty of Science, Muğla Sıtkı Koçman University, Muğla, 48000, Turkey. Electronic address: alextedonkeu@yahoo.fr., Tchegnitegni BT; Department of Chemistry, University of the Western Cape, Bellville, 7535, South Africa; School of Pharmacy, University of the Western Cape, Belville, 7535, South Africa., Küçükaydın S; Department of Medical Services and Techniques, Köyceğiz Vocational School of Health Services, Muğla Sıtkı Koçman University, Koycegiz, Mugla, 48800, Türkiye., Taş Küçükaydın M; Department of Chemistry, Faculty of Science, Muğla Sıtkı Koçman University, Muğla, 48000, Turkey., Antunes EM; Department of Chemistry, University of the Western Cape, Bellville, 7535, South Africa., Beukes DR; School of Pharmacy, University of the Western Cape, Belville, 7535, South Africa., Tene M; Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon., Duru ME; Department of Chemistry, Faculty of Science, Muğla Sıtkı Koçman University, Muğla, 48000, Turkey. Electronic address: eminduru@mu.edu.tr. |
| Πηγή: | Carbohydrate research [Carbohydr Res] 2026 Sep; Vol. 567, pp. 110017. Date of Electronic Publication: 2026 Jun 26. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0043535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-426X (Electronic) Linking ISSN: 00086215 NLM ISO Abbreviation: Carbohydr Res Subsets: MEDLINE |
| Imprint Name(s): | Publication: Amsterdam : Elsevier Original Publication: Amsterdam. |
| Ιατρικοί όροι (MeSH): | Saponins*/chemistry , Saponins*/pharmacology , Saponins*/isolation & purification , Antioxidants*/chemistry , Antioxidants*/pharmacology , Antioxidants*/isolation & purification, alpha-Glucosidases/metabolism ; alpha-Amylases/antagonists & inhibitors ; alpha-Amylases/metabolism ; Cholinesterase Inhibitors/chemistry ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/isolation & purification ; Butyrylcholinesterase/metabolism ; Urease/antagonists & inhibitors ; Urease/metabolism ; Glycoside Hydrolase Inhibitors/chemistry ; Glycoside Hydrolase Inhibitors/pharmacology ; Glycoside Hydrolase Inhibitors/isolation & purification ; Molecular Structure |
| Περίληψη: | Four previously undescribed 13β,28-oxidooleanane-type triterpenoid saponins, maekamerunosides A-D (1-4), together with one new triterpenoid aglycone, maekamerunogenin (6), and the known saponin maesargentoside IV (5), were isolated from the stem bark of Maesa kamerunensis. Their structures were elucidated by extensive spectroscopic analyses (1D and 2D NMR, HR-ESI-MS) and chemical methods, including acid hydrolysis and GC-MS analysis of sugar moieties. The isolated saponins share a common oleanane-type aglycone featuring a rare 13β,28-epoxy bridge and are characterized by complex oligosaccharide chains containing glucuronic acid, galactose, and rhamnose units. Biological evaluation of the MeOH extract, n-BuOH fraction, and isolated compounds (1-5) revealed moderate to significant bioactivities. Compound 4 exhibited the highest antioxidant activity with IC (Copyright © 2026. Published by Elsevier Ltd.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Anti-Urease; Anticholinesterase; Antidiabetic; Antioxidant; Maesa kamerunensis; Saponins |
| Substance Nomenclature: | 0 (Saponins) 0 (Antioxidants) EC 3.2.1.20 (alpha-Glucosidases) EC 3.2.1.1 (alpha-Amylases) 0 (Cholinesterase Inhibitors) EC 3.1.1.8 (Butyrylcholinesterase) EC 3.5.1.5 (Urease) 0 (Glycoside Hydrolase Inhibitors) |
| Entry Date(s): | Date Created: 20260629 Date Completed: 20260708 Latest Revision: 20260708 |
| Update Code: | 20260709 |
| DOI: | 10.1016/j.carres.2026.110017 |
| PMID: | 42372361 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1873-426X |
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| DOI: | 10.1016/j.carres.2026.110017 |