Academic Journal
Evaluation of arteriovenous fistulas of obtuse anastomosis in reducing thrombosis using computational fluid dynamics.
| Τίτλος: | Evaluation of arteriovenous fistulas of obtuse anastomosis in reducing thrombosis using computational fluid dynamics. |
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| Συγγραφείς: | Rostami M; Department of Mechanical Engineering, Central Tehran Branch, Islamic Azad University, Tehran, Islamic Republic of Iran., Abdolalinezhad M; Department of Mechanical Engineering, Sharif University of Technology, Tehran, Islamic Republic of Iran., Hashemi M; School of Mechanical Engineering, College of Engineering, University of Tehran, Tehran, Islamic Republic of Iran., Rahimi MA; Department of Mechanical Engineering, Iran University of Science and Technology, Tehran, Islamic Republic of Iran. |
| Πηγή: | The International journal of artificial organs [Int J Artif Organs] 2026 Aug; Vol. 49 (8), pp. 520-535. Date of Electronic Publication: 2026 Jun 29. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: SAGE Publishing Country of Publication: United States NLM ID: 7802649 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1724-6040 (Electronic) Linking ISSN: 03913988 NLM ISO Abbreviation: Int J Artif Organs Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2018- : Thousand Oaks, CA : SAGE Publishing Original Publication: Milano : Wichtig Editore |
| Ιατρικοί όροι (MeSH): | Arteriovenous Shunt, Surgical*/adverse effects , Arteriovenous Shunt, Surgical*/methods , Thrombosis*/prevention & control , Thrombosis*/etiology , Thrombosis*/physiopathology , Renal Dialysis* , Computer Simulation* , Models, Cardiovascular*, Humans ; Hydrodynamics ; Hemodynamics ; Blood Flow Velocity ; Stress, Mechanical |
| Περίληψη: | Arteriovenous fistula (AVF) failure in hemodialysis patients is strongly influenced by local hemodynamic factors such as elevated wall shear stress, flow separation, and vortex formation. In this study, computational fluid dynamics (CFD) simulations are performed to investigate the influence of anastomosis angle and blood rheology on AVF hemodynamics. Three non-Newtonian blood models (Carreau, power-law, and Casson) are first evaluated at 45°, 90°, and 135° anastomosis angles and validated against available experimental data. Based on shear stress prediction accuracy, the Carreau model is demonstrated as the best agreement and is selected for further simulations. Subsequently, AVFs with 45°, 90°, 110°, 120°, 135°, 145°, and 160° anastomosis angles are analyzed under maximum, medium, and minimum pulsatile flow conditions. Hemodynamic parameters including velocity patterns, wall shear stress distribution, vortex formation, and pressure drop between the proximal artery and vein are evaluated. Results indicate that increasing the anastomosis angle significantly reduces maximum wall shear stress, high-shear regions, vortex intensity, and pressure drop. Compared with the 45° configuration, the 160° angle reduced maximum shear stress by ~78% under peak flow conditions. Overall, obtuse anastomosis angles demonstrated improved hemodynamic performance, suggesting that larger angles may reduce thrombosis risk and cardiovascular burden in hemodialysis patients. Considering both hemodynamic performance and surgical feasibility, the 120° configuration is proposed as a clinically practical and effective option. |
| Competing Interests: | Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. |
| Contributed Indexing: | Keywords: Hemodialysis; fistula obtuse angle; non-Newtonian blood model; shear stress; thrombosis |
| Entry Date(s): | Date Created: 20260629 Date Completed: 20260720 Latest Revision: 20260720 |
| Update Code: | 20260720 |
| DOI: | 10.1177/03913988261455782 |
| PMID: | 42366917 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1724-6040 |
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| DOI: | 10.1177/03913988261455782 |