Academic Journal
VIT-MBRT, a GPU accelerated Monte Carlo tool for investigations on preclinical minibeam radiation therapy.
| Τίτλος: | VIT-MBRT, a GPU accelerated Monte Carlo tool for investigations on preclinical minibeam radiation therapy. |
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| Συγγραφείς: | Luongo N; Istituto Nazionale di Fisica Nucleare, Sezione di Napoli, I-80126 Napoli, Italy; Azienda Ospedaliera Universitaria Policlinico Federico II, I-80131 Napoli, Italy., Crimaldi U; Istituto Nazionale di Fisica Nucleare, Sezione di Napoli, I-80126 Napoli, Italy; Azienda Ospedaliera Universitaria Policlinico Federico II, I-80131 Napoli, Italy; Dipartimento di Scienze Biomediche Avanzate, Università di Napoli Federico II, I-80131 Napoli, Italy., Cerbone LA; Istituto Nazionale di Fisica Nucleare, Sezione di Napoli, I-80126 Napoli, Italy; Scuola Superiore Meridionale, I-80138 Napoli, Italy; Dipartimento di Fisica 'Ettore Pancini', Università di Napoli Federico II, I-80126 Napoli, Italy., Jia X; Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore MD21287, USA., Lai Y; Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore MD21287, USA., Clemente S; Azienda Ospedaliera Universitaria Policlinico Federico II, I-80131 Napoli, Italy., Oliviero C; Azienda Ospedaliera Universitaria Policlinico Federico II, I-80131 Napoli, Italy., Pacelli R; Azienda Ospedaliera Universitaria Policlinico Federico II, I-80131 Napoli, Italy; Dipartimento di Scienze Biomediche Avanzate, Università di Napoli Federico II, I-80131 Napoli, Italy., Spinelli A; Centro di Imaging Sperimentale, IRCCS San Raffaele, I-20132 Milano, Italy., Fiorino C; Fisica Medica, Ospedale San Raffaele, I-20132 Milano, Italy., Pizzardi S; Centro di Imaging Sperimentale, IRCCS San Raffaele, I-20132 Milano, Italy., Russo P; Istituto Nazionale di Fisica Nucleare, Sezione di Napoli, I-80126 Napoli, Italy; Dipartimento di Fisica 'Ettore Pancini', Università di Napoli Federico II, I-80126 Napoli, Italy., Mettivier G; Istituto Nazionale di Fisica Nucleare, Sezione di Napoli, I-80126 Napoli, Italy; Dipartimento di Fisica 'Ettore Pancini', Università di Napoli Federico II, I-80126 Napoli, Italy. Electronic address: mettivier@na.infn.it. |
| Πηγή: | Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) [Phys Med] 2026 Aug; Vol. 148, pp. 105859. Date of Electronic Publication: 2026 Jun 28. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Istituti Editoriali e Poligrafici Internazionali Country of Publication: Italy NLM ID: 9302888 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1724-191X (Electronic) Linking ISSN: 11201797 NLM ISO Abbreviation: Phys Med Subsets: MEDLINE |
| Imprint Name(s): | Publication: Pisa : Istituti Editoriali e Poligrafici Internazionali Original Publication: Lugano, Switzerland : Giardini editori S.A. |
| Ιατρικοί όροι (MeSH): | Monte Carlo Method* , Computer Graphics*, Radiotherapy Planning, Computer-Assisted/methods ; Animals ; Mice ; Phantoms, Imaging ; Cone-Beam Computed Tomography ; Dose Fractionation, Radiation ; Time Factors ; Radiotherapy Dosage |
| Περίληψη: | Purpose: Minibeam Radiation Therapy (MBRT) is a form of spatially fractionated radiation therapy (SFRT) with electrons, protons, ions or kilovoltage photon beams, aiming to improve the therapeutic window compared to broad-beam irradiation. MBRT with X-rays uses an orthovoltage source and an array of narrow beamlets produced by collimator slits with a typical width of 0.2 mm to 0.7 mm and a center-to-center spacing of 1 to 4 mm. We developed an updated version of gCTD, a fast Monte Carlo (MC) code, initially designed for cone-beam CT imaging, to implement a treatment planning system for photon MBRT in mice within a virtual imaging and dosimetry tool (VIT-MBRT). Methods: We compared gCTD, running on a single GPU platform (CUDA environment) with TOPAS, a well validated CPU-based simulation code. We simulated irradiation of a water phantom using a multi-slit tungsten collimator with different aperture width and thickness, producing absorbed dose volume data. An example treatment plan was implemented with the gCTD code, using a voxelized mouse phantom derived from a CT scan and evaluating organ dose-volume histograms. Results: Comparison with TOPAS simulations showed a good agreement in terms of dose values and peak-to-valley dose ratio (maximum absolute discrepancy of 13% at the phantom entrance surface), with a few percent differences in depth. Simulations with gCTD achieved a 300-fold reduction in computational time with respect to corresponding TOPAS simulations. Conclusions: We realized and validated a fast GPU-based MC simulation code for minibeam radiotherapy, as the basis of the MC platform VIT-MBRT for kilovoltage MBRT preclinical treatments. (Copyright © 2026 Associazione Italiana di Fisica Medica e Sanitaria. Published by Elsevier Ltd. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: G. Mettivier, N. Longo, U. Crimaldi, R. Pacelli, A. Spinelli, C. Fiorino reports financial support was provided by Italian Ministry of Health. G. Mettivier, L.A. Cerbone, P. Russo reports financial support was provided by National Institute of Nuclear Physics (INFN). G. Mettivier, Associate Editor, P. Russo, Past Editor, C. Fiorino, Deputy Editor, given their role as menber of Editorial Board, had no involvement in the peer review of this article and had no access to information regarding its peer review. Full responsibility for the editorial process for this article was delegated to another journal editor. The other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: GPU; Minibeam radiation therapy; Monte Carlo simulations; TOPAS |
| Entry Date(s): | Date Created: 20260628 Date Completed: 20260807 Latest Revision: 20260807 |
| Update Code: | 20260808 |
| DOI: | 10.1016/j.ejmp.2026.105859 |
| PMID: | 42365788 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1724-191X |
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| DOI: | 10.1016/j.ejmp.2026.105859 |