Academic Journal
Comparison of Igκ and Igλ binding toward influenza virus hemagglutinin and SARS-CoV-2 Spike protein during primary viral infections in humans, mice, and pigs.
| Τίτλος: | Comparison of Igκ and Igλ binding toward influenza virus hemagglutinin and SARS-CoV-2 Spike protein during primary viral infections in humans, mice, and pigs. |
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| Συγγραφείς: | Richardson RA; Florida Research and Innovation Center, Cleveland Clinic, Port Saint Lucie, FL, USA; Center for Vaccines and Immunology, University of Georgia, Athens, GA, USA., North JF; Department of Pathobiology, Auburn University, Auburn, AL, USA., Thomas MH; Florida Research and Innovation Center, Cleveland Clinic, Port Saint Lucie, FL, USA., Lynch A; Florida Research and Innovation Center, Cleveland Clinic, Port Saint Lucie, FL, USA., Kyriakis CS; Department of Pathobiology, Auburn University, Auburn, AL, USA., Sautto GA; Florida Research and Innovation Center, Cleveland Clinic, Port Saint Lucie, FL, USA., Ross TM; Florida Research and Innovation Center, Cleveland Clinic, Port Saint Lucie, FL, USA; Center for Vaccines and Immunology, University of Georgia, Athens, GA, USA; Department of Infectious Diseases, University of Georgia, Athens, GA, USA. Electronic address: rosst7@ccf.org. |
| Πηγή: | Comparative immunology, microbiology and infectious diseases [Comp Immunol Microbiol Infect Dis] 2026 Jul; Vol. 128, pp. 102494. Date of Electronic Publication: 2026 Jun 23. |
| Τύπος έκδοσης: | Journal Article; Comparative Study |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 7808924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1667 (Electronic) Linking ISSN: 01479571 NLM ISO Abbreviation: Comp Immunol Microbiol Infect Dis Subsets: MEDLINE |
| Imprint Name(s): | Publication: Exeter : Elsevier Science Ltd Original Publication: Oxford, Elmsford, N. Y., Pergamon Press. |
| Ιατρικοί όροι (MeSH): | Spike Glycoprotein, Coronavirus*/immunology , Spike Glycoprotein, Coronavirus*/metabolism , Hemagglutinin Glycoproteins, Influenza Virus*/immunology , Hemagglutinin Glycoproteins, Influenza Virus*/metabolism , SARS-CoV-2*/immunology , Orthomyxoviridae Infections*/immunology , Orthomyxoviridae Infections*/virology , Influenza, Human*/immunology , Influenza, Human*/virology , Immunoglobulin lambda-Chains*/immunology , Immunoglobulin lambda-Chains*/metabolism , Coronavirus Infections*/immunology, Influenza A Virus, H3N2 Subtype/immunology ; Antibodies, Viral/immunology ; Antibodies, Viral/blood ; Influenza A Virus, H1N1 Subtype/immunology ; Animals ; Swine ; Mice ; Humans ; Female |
| Περίληψη: | An Igλ light chain bias (IgL) has been identified in ferrets after a primary influenza virus infections. To further study if this phenotype is consistent between species, serum immunoglobulin Igλ and Igκ light chain (IgL) prevalence was evaluated in humans, mice, and pigs following a primary respiratory virus infection. Each IgL population was tested for its binding capacity to the immunodominant viral glycoprotein of the infecting virus. Humans infected with their initial SARS-CoV-2 virus infection had a marginal Igκ bias against the spike (S) glycoprotein, but had no observable IgL bias toward the receptor binding domain of the S protein. Mice had an Igκ bias against the influenza virus hemagglutinin (HA) after a primary infection with an H1N1 or H3N2 influenza virus. Conversely, pigs had an Igλ bias to the HA after a primary infection with either influenza virus subtype. These results highlight that IgL biases vary in different species after a primary viral respiratory infection. Overall, these results have implications for how immunological data should be interpreted between species and the selection of animal models for various applications. (Copyright © 2026 Elsevier Ltd. All rights reserved.) |
| Competing Interests: | Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Antibody light chain; Humans; Light chain bias; Mice; Pigs; Primary infection |
| Substance Nomenclature: | 0 (Spike Glycoprotein, Coronavirus) 0 (Hemagglutinin Glycoproteins, Influenza Virus) 0 (spike protein, SARS-CoV-2) 0 (Antibodies, Viral) 0 (Immunoglobulin lambda-Chains) |
| Entry Date(s): | Date Created: 20260626 Date Completed: 20260721 Latest Revision: 20260721 |
| Update Code: | 20260722 |
| DOI: | 10.1016/j.cimid.2026.102494 |
| PMID: | 42361778 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1878-1667 |
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| DOI: | 10.1016/j.cimid.2026.102494 |