Academic Journal
Association of Dietary Animal and Plant Protein Composition with All-Cause Mortality: 24-Year Population-Based Cohort Study.
| Τίτλος: | Association of Dietary Animal and Plant Protein Composition with All-Cause Mortality: 24-Year Population-Based Cohort Study. |
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| Συγγραφείς: | Prinelli F; Institute of Biomedical Technologies, National Research Council, Via Fratelli Cervi 93, 20054 Segrate, MI, Italy., Russo AG; Epidemiology Unit, Agency for Health Protection of the Metropolitan City of Milan, Via Conca del Naviglio, 45, 20123 Milano, MI, Italy. |
| Πηγή: | Nutrients [Nutrients] 2026 Jun 22; Vol. 18 (12). Date of Electronic Publication: 2026 Jun 22. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI Publishing |
| Ιατρικοί όροι (MeSH): | Animal Proteins, Dietary*/analysis , Plant Proteins*/analysis , Diet*/mortality , Mortality* , Dietary Proteins*, Italy/epidemiology ; Obesity/mortality ; Overweight/mortality ; Humans ; Female ; Male ; Middle Aged ; Aged ; Adult ; Longitudinal Studies ; Proportional Hazards Models ; Animals ; Risk Factors ; Smoking ; Body Mass Index |
| Περίληψη: | Background: This study examined the associations of dietary animal (AP) and plant protein (PP) with all-cause mortality in an Italian population and assessed the potential effect modification by sex, smoking status, and overweight/obesity (defined as BMI ≥ 25 kg/m2). Methods: This longitudinal population-based study included 1350 adults (50.2% females), aged 40-74 years, recruited between 1991 and 1995, who were followed for all-cause mortality through the regional mortality registry until 2015. Dietary data were collected using a food frequency questionnaire, and protein composition was analysed within a compositional data analysis framework, modelling the balance of AP and PP within the overall macronutrient composition. The associations of protein balances with all-cause mortality were estimated using Cox proportional hazards models adjusted for potential confounders. Effect modification was evaluated through stratified analyses. Results: During follow-up, 405 deaths occurred. A greater AP relative to other macronutrients was associated with higher mortality overall (hazard ratio (HR): 1.37; 95% confidence interval (CI): 1.00-1.87) and in males (HR: 1.57; 95% CI: 1.05-2.33). In stratified analyses, these associations were restricted to ever smokers overall (HR 2.06, 95% CI 1.32-3.20), males (HR 1.90, 95% CI 1.18-3.06), females (HR 3.29, 95% CI 1.03-10.54), and to participants with normal weight (HR 1.91, 95% CI 1.07-3.41). No overall association was observed for PP. Among females, PP was associated with lower mortality in those with normal weight. Conclusions: The associations between AP and PP and mortality differed by sex, smoking status, and adiposity, supporting more tailored dietary recommendations. |
| Contributed Indexing: | Keywords: all-cause mortality; compositional data analysis; dietary proteins; population-based cohort study |
| Substance Nomenclature: | 0 (Animal Proteins, Dietary) 0 (Plant Proteins) 0 (Dietary Proteins) |
| Entry Date(s): | Date Created: 20260626 Date Completed: 20260626 Latest Revision: 20260726 |
| Update Code: | 20260726 |
| PubMed Central ID: | PMC13304937 |
| DOI: | 10.3390/nu18122035 |
| PMID: | 42356421 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2072-6643 |
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| DOI: | 10.3390/nu18122035 |