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Association of E-Selectin with Inflammation, Mineral and Bone Disorder, and Endothelial Dysfunction in Hemodialysis Patients.

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Τίτλος: Association of E-Selectin with Inflammation, Mineral and Bone Disorder, and Endothelial Dysfunction in Hemodialysis Patients.
Συγγραφείς: Rusu CC; Discipline of Nephrology, 'Iuliu Hatieganu' University of Medicine and Pharmacy, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania.; Department of Nephrology, County Emergency Clinical Hospital Cluj, 3-5 Clinicilor Street, 400006 Cluj-Napoca, Romania., Moldovan D; Discipline of Nephrology, 'Iuliu Hatieganu' University of Medicine and Pharmacy, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania.; Department of Nephrology, County Emergency Clinical Hospital Cluj, 3-5 Clinicilor Street, 400006 Cluj-Napoca, Romania., Potra A; Discipline of Nephrology, 'Iuliu Hatieganu' University of Medicine and Pharmacy, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania.; Department of Nephrology, County Emergency Clinical Hospital Cluj, 3-5 Clinicilor Street, 400006 Cluj-Napoca, Romania., Tirinescu D; Discipline of Nephrology, 'Iuliu Hatieganu' University of Medicine and Pharmacy, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania.; Department of Nephrology, County Emergency Clinical Hospital Cluj, 3-5 Clinicilor Street, 400006 Cluj-Napoca, Romania., Ticala M; Discipline of Nephrology, 'Iuliu Hatieganu' University of Medicine and Pharmacy, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania.; Department of Nephrology, County Emergency Clinical Hospital Cluj, 3-5 Clinicilor Street, 400006 Cluj-Napoca, Romania., Maslyennikov Y; Discipline of Nephrology, 'Iuliu Hatieganu' University of Medicine and Pharmacy, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania.; Department of Nephrology, County Emergency Clinical Hospital Cluj, 3-5 Clinicilor Street, 400006 Cluj-Napoca, Romania., Urs A; Discipline of Nephrology, 'Iuliu Hatieganu' University of Medicine and Pharmacy, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania.; Department of Nephrology, County Emergency Clinical Hospital Cluj, 3-5 Clinicilor Street, 400006 Cluj-Napoca, Romania., Pop RM; Discipline of Pharmacology, Toxicology and Clinical Pharmacology, 'Iuliu Hatieganu' University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania., Ticolea M; Discipline of Pathophysiology, 'Iuliu Hatieganu' University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania., Bondor CI; Discipline of Medical Informatics and Biostatistics, 'Iuliu Hatieganu' University of Medicine and Pharmacy, 6 Pasteur Street, 400349 Cluj-Napoca, Romania., Kacso I; Discipline of Nephrology, 'Iuliu Hatieganu' University of Medicine and Pharmacy, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania.; Department of Nephrology, County Emergency Clinical Hospital Cluj, 3-5 Clinicilor Street, 400006 Cluj-Napoca, Romania.
Πηγή: International journal of molecular sciences [Int J Mol Sci] 2026 Jun 06; Vol. 27 (12). Date of Electronic Publication: 2026 Jun 06.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
Imprint Name(s): Original Publication: Basel, Switzerland : MDPI, [2000-
Ιατρικοί όροι (MeSH): E-Selectin*/blood , E-Selectin*/metabolism , Renal Dialysis*/adverse effects , Inflammation*/metabolism , Inflammation*/blood , Endothelium, Vascular*/metabolism , Endothelium, Vascular*/physiopathology , Bone Diseases*/metabolism , Bone Diseases*/etiology, Biomarkers/blood ; Antigens, CD/blood ; Parathyroid Hormone/blood ; Receptors, Cell Surface/blood ; Humans ; Middle Aged ; Female ; Male ; Aged ; Cross-Sectional Studies
Περίληψη: Endothelial dysfunction is an early step in atherogenesis, and adhesion molecules such as E-selectin may serve as biomarkers or therapeutic targets. This study aimed to evaluate the relationship between E-selectin and inflammatory, nutritional, and mineral-bone metabolism markers in hemodialysis (HD) patients, as well as its association with endothelial function assessed by flow-mediated dilation (FMD). We conducted a cross-sectional study including 68 HD patients (mean age 59.7 ± 12.5 years). Clinical and laboratory parameters were assessed, including inflammatory, nutritional, and mineral-bone disorder markers. Associations with E-selectin were analyzed using bivariate and multivariable models. Endothelial function was evaluated using FMD. In multivariable analysis, alkaline phosphatase (ALP) (p = 0.002), intact parathyroid hormone (iPTH) (p = 0.001), white blood cell count (WBC) (p = 0.015), and soluble CD163 (sCD163) (p = 0.042) were independently associated with E-selectin. In the subgroup with high hs-CRP values, a significant increase was observed in both E-selectin levels and adiposity tissue markers (adipose tissue mass and waist circumference). In younger patients with inflammation, E-selectin was inversely correlated with FMD (ρ = -0.64, p = 0.008). In conclusion, E-selectin was associated with markers of inflammation, mineral-bone disorder, and endothelial dysfunction in hemodialysis (HD) patients. Novel associations of E-Selectin with sCD163 and ALP were identified.
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Contributed Indexing: Keywords: E-selectin; cardiovascular complication; endothelial dysfunction; hemodialysis; inflammation; mineral and bone disorders; sCD163
Substance Nomenclature: 0 (E-Selectin)
0 (Biomarkers)
0 (Antigens, CD)
0 (Parathyroid Hormone)
0 (SELE protein, human)
0 (Receptors, Cell Surface)
Entry Date(s): Date Created: 20260626 Date Completed: 20260626 Latest Revision: 20260813
Update Code: 20260814
PubMed Central ID: PMC13299510
DOI: 10.3390/ijms27125156
PMID: 42352880
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1422-0067
DOI:10.3390/ijms27125156