Academic Journal
Chronic stress impairs multi-scale visual processing in V1.
| Τίτλος: | Chronic stress impairs multi-scale visual processing in V1. |
|---|---|
| Συγγραφείς: | Yang X; Department of Neurosurgery, Sichuan Provincial People's Hospital, MOE Key Laboratory for Neuro-Information, Brain-Apparatus Communication Institute, University of Electronic Science and Technology of China, Chengdu, 611731, China., Yang Z; Department of Neurosurgery, Sichuan Provincial People's Hospital, MOE Key Laboratory for Neuro-Information, Brain-Apparatus Communication Institute, University of Electronic Science and Technology of China, Chengdu, 611731, China., Wang Z; Department of Neurosurgery, Sichuan Provincial People's Hospital, MOE Key Laboratory for Neuro-Information, Brain-Apparatus Communication Institute, University of Electronic Science and Technology of China, Chengdu, 611731, China., Xie Y; Department of Neurosurgery, Sichuan Provincial People's Hospital, MOE Key Laboratory for Neuro-Information, Brain-Apparatus Communication Institute, University of Electronic Science and Technology of China, Chengdu, 611731, China., Yao D; Department of Neurosurgery, Sichuan Provincial People's Hospital, MOE Key Laboratory for Neuro-Information, Brain-Apparatus Communication Institute, University of Electronic Science and Technology of China, Chengdu, 611731, China. Electronic address: dyao@uestc.edu.cn., Xia Y; Department of Neurosurgery, Sichuan Provincial People's Hospital, MOE Key Laboratory for Neuro-Information, Brain-Apparatus Communication Institute, University of Electronic Science and Technology of China, Chengdu, 611731, China. Electronic address: xiayang@uestc.edu.cn., Chen K; Department of Neurosurgery, Sichuan Provincial People's Hospital, MOE Key Laboratory for Neuro-Information, Brain-Apparatus Communication Institute, University of Electronic Science and Technology of China, Chengdu, 611731, China. Electronic address: chenke0703@uestc.edu.cn. |
| Πηγή: | Life sciences [Life Sci] 2026 Sep 15; Vol. 401, pp. 124552. Date of Electronic Publication: 2026 Jun 24. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci Subsets: MEDLINE |
| Imprint Name(s): | Publication: <2008->: Amsterdam : Elsevier Original Publication: Oxford; Elmsford, N. Y. [etc.] Pergamon Press. |
| Ιατρικοί όροι (MeSH): | Stress, Psychological*/physiopathology , Visual Perception*/physiology , Visual Cortex*/physiopathology , Primary Visual Cortex*/physiopathology, Evoked Potentials, Visual/physiology ; Neurons/physiology ; Major Depressive Disorder/physiopathology ; Animals ; Mice ; Male ; Mice, Inbred C57BL ; Chronic Disease ; Photic Stimulation ; Restraint, Physical |
| Περίληψη: | Visual perceptual deficits are increasingly acknowledged as a core yet underexplored feature of Major Depressive Disorder (MDD), involving impairments in contrast sensitivity, contextual modulation, and social-emotional perception. However, the underlying circuit-, neuron-, and network-level mechanisms through which depressive states influence early visual processing remain poorly understood. In this study, mice subjected to chronic restraint stress (CRS) underwent single-unit recordings in layer 2/3 (L2/3) of the primary visual cortex (V1) under light anesthesia to examine the effects of chronic stress on visually evoked neuronal responses and local network dynamics. V1 neurons in CRS-exposed mice exhibited broadened orientation tuning bandwidths, diminished surround suppression, and impaired center-surround discontinuity discrimination. At the network level, visually evoked oscillatory power in the θ, low γand high γ frequency bands was significantly attenuated in CRS mice, accompanied by a marked reduction in visual evoked potential (VEP) amplitude. These findings show that chronic stress impairs both the tuning of V1 neurons to visual stimuli and the local neural rhythms underlying early visual processing. The results uncover a multi-level physiological basis for depression-related visual deficits and provide a preclinical framework that could help develop objective sensory biomarkers for MDD. (Copyright © 2026 Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare no competing interests. |
| Contributed Indexing: | Keywords: Chronic restraint stress; Neuronal tuning; Primary visual cortex; Single-unit activity; Visual evoked potential; Visual processing; Γ oscillations |
| Entry Date(s): | Date Created: 20260624 Date Completed: 20260702 Latest Revision: 20260702 |
| Update Code: | 20260703 |
| DOI: | 10.1016/j.lfs.2026.124552 |
| PMID: | 42342066 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1879-0631 |
|---|---|
| DOI: | 10.1016/j.lfs.2026.124552 |