Academic Journal
Comprehensive mapping of identical sequences across human proteins emphasizes the widespread issue of shared epitopes in self-antigens.
| Τίτλος: | Comprehensive mapping of identical sequences across human proteins emphasizes the widespread issue of shared epitopes in self-antigens. |
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| Συγγραφείς: | Kellermann G; Telomium SAS, Ivry-sur-Seine 94200, France., Croce O; Université Côte d'Azur, Institute for Research on Cancer and Aging, Nice (IRCAN), Centre national de la recherche scientifique (CNRS), Institut national de la santé et de la recherche médicale (INSERM), Institut Hospitalo-Universitaire (IHU) RespirERA, Fédération Hospitalo-Universitaire (FHU) OncoAge, Nice, France., Mograbi B; Université Côte d'Azur, Institute for Research on Cancer and Aging, Nice (IRCAN), Centre national de la recherche scientifique (CNRS), Institut national de la santé et de la recherche médicale (INSERM), Institut Hospitalo-Universitaire (IHU) RespirERA, Fédération Hospitalo-Universitaire (FHU) OncoAge, Nice, France., Hofman P; Université Côte d'Azur, Institute for Research on Cancer and Aging, Nice (IRCAN), Centre national de la recherche scientifique (CNRS), Institut national de la santé et de la recherche médicale (INSERM), Institut Hospitalo-Universitaire (IHU) RespirERA, Fédération Hospitalo-Universitaire (FHU) OncoAge, Nice, France.; Laboratory of Clinical and Experimental Pathology, Centre Hospitalier Universitaire (CHU) de Nice, IHU RespirERA, FHU OncoAge, Biobank BB-0033-00025, Nice, France., Brest P; Université Côte d'Azur, Institute for Research on Cancer and Aging, Nice (IRCAN), Centre national de la recherche scientifique (CNRS), Institut national de la santé et de la recherche médicale (INSERM), Institut Hospitalo-Universitaire (IHU) RespirERA, Fédération Hospitalo-Universitaire (FHU) OncoAge, Nice, France. |
| Πηγή: | NAR genomics and bioinformatics [NAR Genom Bioinform] 2026 Jun 22; Vol. 8 (2), pp. lqag060. Date of Electronic Publication: 2026 Jun 22 (Print Publication: 2026). |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Oxford University Press Country of Publication: England NLM ID: 101756213 Publication Model: eCollection Cited Medium: Internet ISSN: 2631-9268 (Electronic) Linking ISSN: 26319268 NLM ISO Abbreviation: NAR Genom Bioinform Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [Oxford] : Oxford University Press, [2019]- |
| Ιατρικοί όροι (MeSH): | Autoantigens*/immunology , Autoantigens*/chemistry , Autoantigens*/genetics , Epitopes*/immunology , Epitopes*/chemistry , Epitopes*/genetics , Epitope Mapping*/methods, Antigens, Neoplasm/immunology ; Antigens, Neoplasm/chemistry ; Antigens, Neoplasm/genetics ; Humans ; Animals ; Mice ; Amino Acid Sequence ; Immunoinformatics ; Software |
| Περίληψη: | Shared epitopes pose safety and efficacy issues for T-cell immunotherapy. To characterize the extent of this problem, we performed a computational analysis establishing a complete atlas of shared identical sequences across the human and murine proteomes. Unlike bacterial or viral antigens, self-antigens, including tumor-associated antigens (TAAs), frequently contain sequences of sufficient length to generate identical epitopes in other self-proteins. Epitopes from these shared sequences can theoretically reduce target specificity, confound immunomonitoring studies, and contribute to pre-existing immune tolerance toward TAAs. Notably, a subset of TAAs identified in this atlas is free of this drawback, providing a new criterion for antigen prioritization in cancer immunotherapy. To facilitate the detection of shared sequences, a web server has been made available at https://epitopemapper.ircan.org/ and the open-source code at https://github.com/IRCAN/EpitopeMapper. (© The Author(s) 2026. Published by Oxford University Press.) |
| Competing Interests: | G.K. is shareholder of Telomium, a company developing cancer vaccines. Other authors have no conflict of interest. |
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| Substance Nomenclature: | 0 (Autoantigens) 0 (Epitopes) 0 (Antigens, Neoplasm) |
| Entry Date(s): | Date Created: 20260624 Date Completed: 20260624 Latest Revision: 20260813 |
| Update Code: | 20260813 |
| PubMed Central ID: | PMC13284612 |
| DOI: | 10.1093/nargab/lqag060 |
| PMID: | 42338745 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2631-9268 |
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| DOI: | 10.1093/nargab/lqag060 |