Academic Journal
Aptagel Plasmonic Fiber Optic Biosensor for In Vivo Continuous Drug Monitoring.
| Τίτλος: | Aptagel Plasmonic Fiber Optic Biosensor for In Vivo Continuous Drug Monitoring. |
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| Συγγραφείς: | Satapathy P; BioMed X Institute, Heidelberg69120, Germany., Park S; BioMed X Institute, Heidelberg69120, Germany., Pal A; BioMed X Institute, Heidelberg69120, Germany., Santa C; BioMed X Institute, Heidelberg69120, Germany., Koros E; N&MH-Neuroscience and Mental Health, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß88400, Germany., Schweimer J; N&MH-Neuroscience and Mental Health, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß88400, Germany., Hasler R; LiST-Life Sciences Technology, Danube Private University , Neustadt2700, Austria., Dostalek J; LiST-Life Sciences Technology, Danube Private University , Neustadt2700, Austria.; FZU-Institute of Physics, Czech Academy of Sciences, Prague180 00, Czech Republic., Clark H; School of Biological and Health Systems Engineering, Arizona State University, Tempe, Arizona85281, United States., Arban R; N&MH-Neuroscience and Mental Health, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß88400, Germany., Hengerer B; N&MH-Neuroscience and Mental Health, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß88400, Germany., Sergelen K; BioMed X Institute, Heidelberg69120, Germany. |
| Πηγή: | ACS sensors [ACS Sens] 2026 Jul 24; Vol. 11 (7), pp. 5858-5868. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101669031 Publication Model: Print Cited Medium: Internet ISSN: 2379-3694 (Electronic) Linking ISSN: 23793694 NLM ISO Abbreviation: ACS Sens Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Washington, DC : American Chemical Society, [2016]- |
| Ιατρικοί όροι (MeSH): | Vancomycin*/analysis , Vancomycin*/blood , Vancomycin*/administration & dosage , Fiber Optic Technology*/methods , Fiber Optic Technology*/instrumentation , Aptamers, Nucleotide*/chemistry , Surface Plasmon Resonance*/methods , Surface Plasmon Resonance*/instrumentation , Drug Monitoring*/methods , Drug Monitoring*/instrumentation , Biosensing Techniques*/methods , Biosensing Techniques*/instrumentation, Hydrogels/chemistry ; Animals ; Rats ; Optical Fibers |
| Περίληψη: | Continuous monitoring of drug dynamics directly in living tissue remains a major challenge, notably in the brain, where the blood-brain barrier creates distinct microenvironments. Here, we report an implantable fiber optic surface plasmon resonance (FO-SPR) biosensor coated with aptagel, a split-aptamer-crosslinked hydrogel, for continuous monitoring of a small-molecule drug, vancomycin. The aptagel undergoes analyte-induced volumetric and refractive index changes, providing a self-contained means for reversible, label-free optical detection via shifts in the SPR wavelength (λSPR) while ensuring sensor stability in complex physiological matrices. The sensing area was miniaturized to 3 mm2 (3 mm length, 300 μm diameter) for cortical implantation while maintaining sensitivity of >2000 nm/RIU. The sensor performed consistently in vitro across diverse biological media, including blood serum, with detection limits of 1.7-2.5 μM. Upon implantation into the rat cortex, time-resolved λSPR signals were recorded over several hours after intravenous vancomycin administration, representing to our knowledge the first demonstration of plasmonic fiber-based monitoring of a small-molecule drug directly in brain tissue. Baseline-corrected shifts (ΔλSPR) captured in vivo drug dynamics, with a consistent absorption phase but with inter-animal variability in peak amplitude and clearance kinetics. This work establishes a proof-of-concept platform for continuous optical monitoring in deep tissue and highlights the potential of FO-SPR sensing for in vivo pharmacokinetic applications. (© 2026 American Chemical Society.) |
| Grant Information: | Project BDB at BioMed X Institute Boehringer Ingelheim; SENDISO -CZ.02.01.01/00/22_008/0004596 Ministerstvo Školství, Mládeže a Telovýchovy; 22-30456J Grantová Agentura Ceské Republiky; 915477 Österreichische Forschungsförderungsgesellschaft |
| Contributed Indexing: | Keywords: aptamer; hydrogel; in vivo; plasmonic fiber optic; precision medicine |
| Substance Nomenclature: | 6Q205EH1VU (Vancomycin) 0 (Aptamers, Nucleotide) 0 (Hydrogels) |
| Entry Date(s): | Date Created: 20260623 Date Completed: 20260811 Latest Revision: 20260812 |
| Update Code: | 20260813 |
| DOI: | 10.1021/acssensors.6c00681 |
| PMID: | 42334278 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2379-3694 |
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| DOI: | 10.1021/acssensors.6c00681 |