Academic Journal
Dose and LET-dependence of gastric cancer risk in Apc1638N/+ mice exposed to space-relevant radiation types.
| Τίτλος: | Dose and LET-dependence of gastric cancer risk in Apc1638N/+ mice exposed to space-relevant radiation types. |
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| Συγγραφείς: | Suman S; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, WA, DC, USA. Electronic address: ss2286@georgetown.edu., Kumar S; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, WA, DC, USA., Angdisen J; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, WA, DC, USA., Kallakury BV; Department of Pathology, Georgetown University Medical Center, WA, DC, USA., Datta K; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, WA, DC, USA., Fornace AJ Jr; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, WA, DC, USA; Center for Radiological Research, Columbia University, NY, NY, USA; Department of Biochemistry and Molecular & Cellular Biology and Department of Oncology, Georgetown University Medical Center, WA, DC, USA. |
| Πηγή: | Life sciences in space research [Life Sci Space Res (Amst)] 2026 Jul; Vol. 51, pp. 64-70. Date of Electronic Publication: 2026 Jan 20. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Ltd Country of Publication: Netherlands NLM ID: 101632373 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2214-5532 (Electronic) Linking ISSN: 22145524 NLM ISO Abbreviation: Life Sci Space Res (Amst) Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam : Elsevier Ltd, [2014]- |
| Ιατρικοί όροι (MeSH): | Stomach Neoplasms*/etiology , Stomach Neoplasms*/pathology , Neoplasms, Radiation-Induced*/etiology , Neoplasms, Radiation-Induced*/pathology , Cosmic Radiation*/adverse effects , Heavy Ions*/adverse effects , Linear Energy Transfer*, Gamma Rays/adverse effects ; Animals ; Male ; Mice ; Dose-Response Relationship, Radiation |
| Περίληψη: | Exposure to high-linear energy transfer (LET) heavy ions (Z > 2) present in galactic cosmic radiation (GCR) is predicted to pose a significant but uncertain risk of gastric (stomach) cancer among astronauts. Uncertainties in current risk estimate models are primarily attributed to the lack of in vivo radiobiological data on dose- and LET-responses of high-LET heavy-ions. To address this gap, we investigated dose- and LET-dependent gastric tumorigenesis in male Apc1638N/+ mice following exposure to γ rays and 28Si ions (69 keV/μm) at doses of 5, 10, and 50 cGy. Additionally, a separate cohort of mice were exposed to 10 cGy of 4He (1.6 keV/μm), 56Fe (148 keV/μm), and 50 cGy of sequentially delivered 4-ions (60 % 1H, 20 % 4He, 10 % 16O, and 10 % 28Si ions) GCR simulation (GCRsim). Animals were euthanized at 5 months post-exposure and formalin-fixed hematoxylin and eosin-stained gastric tissues sections were used for tumor counting as well as for carcinoma identification. Both γ and 28Si induced a dose-dependent increase in tumor burden, with 28Si producing a more pronounced tumorigenic and carcinogenic response. Additionally, the relative risk of carcinoma in the 50 cGy GCRsim group was 12.25, that far exceed the relative risk of 3.5 noted after 50 cGy γ radiation. Further we demonstrate exposure to 69 keV/μm 28Si-ion radiation as a more potent driver of gastric tumorigenesis exceeding those of both γ (∼0.2 keV/μm) and 148 keV/μm 56Fe-ion radiation, suggesting a non-linear response. These findings underscore the potentially disproportionate biological impact of intermediate high-LET ions, such as 28Si, within the complex GCR environment. (Copyright © 2026 The Authors. Published by Elsevier B.V. All rights reserved.) |
| Competing Interests: | Declaration of interest statement The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Apc(1638N/+) mice; Ionizing radiation, Galactic cosmic radiation, Gastric cancer risk, Heavy-ions; Linear energy transfer |
| Entry Date(s): | Date Created: 20260622 Date Completed: 20260623 Latest Revision: 20260622 |
| Update Code: | 20260623 |
| DOI: | 10.1016/j.lssr.2026.01.006 |
| PMID: | 42331462 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2214-5532 |
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| DOI: | 10.1016/j.lssr.2026.01.006 |