Academic Journal
Region-specific high-frequency oscillations under propofol anesthesia: comparison of epileptogenic and functional cortex.
| Title: | Region-specific high-frequency oscillations under propofol anesthesia: comparison of epileptogenic and functional cortex. |
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| Authors: | Sakuraba-Hirata R; Department of Epileptology, Tohoku University Graduate School of Medicine, Japan; Department of Clinical Laboratory Sciences School of Health Sciences, Fukushima Medical University, Japan., Osawa SI; Department of Neurosurgery, Tohoku University Graduate School of Medicine, Japan. Electronic address: osws@tohoku.ac.jp., Ukishiro K; Department of Epileptology, Tohoku University Graduate School of Medicine, Japan., Iwasaki M; Department of Neurosurgery, National Center Hospital, National Center of Neurology and Psychiatry, Japan., Sugiyama SI; Department of Neuroanesthesia, Kohnan Hospital, Japan., Kakisaka Y; Tohoku University School of Medicine Office of Medical Education, Japan., Jin K; Department of Epileptology, Tohoku University Graduate School of Medicine, Japan., Uematsu M; Department of Pediatrics, Tohoku University Graduate School of Medicine, Japan., Okumura E; Department of Epileptology, Tohoku University Graduate School of Medicine, Japan., Horikoshi Y; Department of Clinical Laboratory Sciences School of Health Sciences, Fukushima Medical University, Japan., Nakasato N; Department of Epileptology, Tohoku University Graduate School of Medicine, Japan., Nishio Y; Department of Behavioral Neurology and Neuropsychiatry, Osaka University United Graduate School of Child Development, Japan., Suzuki K; Department of Behavioral and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Japan., Yoshihisa A; Department of Clinical Laboratory Sciences School of Health Sciences, Fukushima Medical University, Japan; Department of Cardiovascular Medicine, Fukushima Medical University, Japan., Endo H; Department of Neurosurgery, Tohoku University Graduate School of Medicine, Japan. |
| Source: | Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology [Clin Neurophysiol] 2026 Oct; Vol. 190, pp. 2111982. Date of Electronic Publication: 2026 Jun 16. |
| Publication Type: | Journal Article; Comparative Study |
| Language: | English |
| Journal Info: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 100883319 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8952 (Electronic) Linking ISSN: 13882457 NLM ISO Abbreviation: Clin Neurophysiol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam : Elsevier, c1999- |
| MeSH Terms: | Propofol*/administration & dosage , Propofol*/pharmacology , Cerebral Cortex*/physiopathology , Cerebral Cortex*/drug effects , Anesthetics, Intravenous*/administration & dosage , Anesthetics, Intravenous*/pharmacology , Drug Resistant Epilepsy*/physiopathology , Drug Resistant Epilepsy*/surgery , Brain Waves*/drug effects , Brain Waves*/physiology, Electroencephalography/methods ; Electrocorticography/methods ; Humans ; Female ; Male ; Retrospective Studies ; Adult ; Young Adult ; Adolescent |
| Abstract: | Objective: To determine whether the rates of pathological and physiological high-frequency oscillations (HFOs; 80-200 Hz) differ between non-rapid eye movement sleep (NREM) and propofol anesthesia (PA). Methods: We retrospectively analyzed 11 patients with drug-resistant epilepsy who underwent chronic intracranial EEG monitoring and intraoperative EEG recording under PA. Among 761implanted electrodes, 29 sites were classified as epileptogenic cortex (EC), defined as seizure onset sites whose resection resulted in postoperative seizure freedom. Fifty-eight sites were classified as functional cortex (motor, somatosensory, visual, or language) based on electrical stimulation mapping. None of these 87 sites exhibited interictal spikes or overlapped between epileptogenic and functional categories. We examined whether PA altered HFO rates compared with NREM. Results: HFO rates remained stable between NREM and PA. HFO rates in epileptogenic and visual cortical sites were higher than those in other functional sites (p < 0.05). HFO rates were comparable between epileptogenic and visual cortical sites, with no significant differences in either state. Although the EC showed higher HFO rates than most functional cortices, the visual cortex displayed HFO rates comparable to the EC, with no significant differences in either state (NREM, p = 0.87; PA, p = 0.66). Conclusion: Under both NREM and PA, the rate of pathological HFOs exceeded that of physiological HFOs, except those generated in the visual cortex. Significance: Distinct patterns of pathological and physiological HFOs may aid interpretation of intraoperative recordings obtained under PA, although caution is required for occipital HFOs. (Copyright © 2026 The Authors. Published by Elsevier B.V. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Epilepsy surgery; Functional cortex; High frequency oscillations; Intracranial electroencephalography; Non-rapid eye movement sleep; Propofol anesthesia |
| Substance Nomenclature: | YI7VU623SF (Propofol) 0 (Anesthetics, Intravenous) |
| Entry Date(s): | Date Created: 20260620 Date Completed: 20260812 Latest Revision: 20260812 |
| Update Code: | 20260813 |
| DOI: | 10.1016/j.clinph.2026.2111982 |
| PMID: | 42322804 |
| Database: | MEDLINE |
| ISSN: | 1872-8952 |
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| DOI: | 10.1016/j.clinph.2026.2111982 |