Academic Journal
Development of in situ dosimetry for FLASH proton radiotherapy via organic scintillating fibers.
| Τίτλος: | Development of in situ dosimetry for FLASH proton radiotherapy via organic scintillating fibers. |
|---|---|
| Συγγραφείς: | Olson C; Department of Civil and Environmental Engineering, University of Utah Nuclear Engineering Program, Salt Lake City, UT 84112, United States., Strong J; Department of Civil and Environmental Engineering, University of Utah Nuclear Engineering Program, Salt Lake City, UT 84112, United States., Paxton A; Department of Radiation Oncology, Huntsman Cancer Institute, Salt Lake City, UT 84112, United States., Nelson G; Department of Radiation Oncology, Huntsman Cancer Institute, Salt Lake City, UT 84112, United States., Cazalas E; Department of Civil and Environmental Engineering, University of Utah Nuclear Engineering Program, Salt Lake City, UT 84112, United States. |
| Πηγή: | The British journal of radiology [Br J Radiol] 2026 Oct 01; Vol. 99 (1186), pp. 2117-2128. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Oxford University Press Country of Publication: England NLM ID: 0373125 Publication Model: Print Cited Medium: Internet ISSN: 1748-880X (Electronic) Linking ISSN: 00071285 NLM ISO Abbreviation: Br J Radiol Subsets: MEDLINE |
| Imprint Name(s): | Publication: January 2024- : [Oxford] : Oxford University Press Original Publication: London, British Institute of Radiology. |
| Ιατρικοί όροι (MeSH): | Proton Therapy*/instrumentation , Proton Therapy*/methods , Radiometry*/instrumentation , Radiometry*/methods , Scintillation Counting*/instrumentation, Equipment Design ; Radiotherapy Dosage ; Humans |
| Περίληψη: | Objectives: This work presents the design, development, and initial proof-of-concept testing of a dosimetry device intended for FLASH radiotherapy. Methods: The system incorporates organic scintillating fibers coupled to a silicon photomultiplier (SiPM) and an FPGA-based readout, with fiber geometry optimized to minimize perturbations to a clinical proton beam, as confirmed through measurements at the Huntsman Cancer Institute (HCI). Results: Tests using a portable X-ray unit demonstrated a strong correlation between integrated charge and delivered dose (up to ∼35 mrem s-1) and showed that the detector can respond on nanosecond timescales, enabling rapid safety interlock triggering with minimal latency. Conclusion: Preliminary proton irradiations at HCI further indicated that the device can resolve individual beam pulses, a capability valuable for both FLASH research and conventional radiotherapy. Advances in Knowledge: These results highlight the need for continued refinement of the experimental setup, readout electronics, and detector performance to fully realize real-time, in situ dose and pulse monitoring. (© The Author(s) 2026. Published by Oxford University Press on behalf of the British Institute of Radiology.) |
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| Contributed Indexing: | Keywords: FLASH; GEANT4; dosimetry; proton; radiotherapy |
| Entry Date(s): | Date Created: 20260619 Date Completed: 20260929 Latest Revision: 20261001 |
| Update Code: | 20261001 |
| PubMed Central ID: | PMC13623240 |
| DOI: | 10.1093/bjr/tqag152 |
| PMID: | 42319906 |
| Βάση Δεδομένων: | MEDLINE |
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