Academic Journal
Development of in situ dosimetry for FLASH proton radiotherapy via organic scintillating fibers.
| Τίτλος: | Development of in situ dosimetry for FLASH proton radiotherapy via organic scintillating fibers. |
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| Συγγραφείς: | Olson C; Department of Civil and Environmental Engineering, University of Utah Nuclear Engineering Program, Salt Lake City, UT 84112, United States., Strong J; Department of Civil and Environmental Engineering, University of Utah Nuclear Engineering Program, Salt Lake City, UT 84112, United States., Paxton A; Department of Radiation Oncology, Huntsman Cancer Institute, Salt Lake City, UT 84112, United States., Nelson G; Department of Radiation Oncology, Huntsman Cancer Institute, Salt Lake City, UT 84112, United States., Cazalas E; Department of Civil and Environmental Engineering, University of Utah Nuclear Engineering Program, Salt Lake City, UT 84112, United States. |
| Πηγή: | The British journal of radiology [Br J Radiol] 2026 Oct 01; Vol. 99 (1186), pp. 2117-2128. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Oxford University Press Country of Publication: England NLM ID: 0373125 Publication Model: Print Cited Medium: Internet ISSN: 1748-880X (Electronic) Linking ISSN: 00071285 NLM ISO Abbreviation: Br J Radiol Subsets: MEDLINE |
| Imprint Name(s): | Publication: January 2024- : [Oxford] : Oxford University Press Original Publication: London, British Institute of Radiology. |
| Ιατρικοί όροι (MeSH): | Proton Therapy*/instrumentation , Proton Therapy*/methods , Radiometry*/instrumentation , Radiometry*/methods , Scintillation Counting*/instrumentation, Equipment Design ; Radiotherapy Dosage ; Humans |
| Περίληψη: | Objectives: This work presents the design, development, and initial proof-of-concept testing of a dosimetry device intended for FLASH radiotherapy. Methods: The system incorporates organic scintillating fibers coupled to a silicon photomultiplier (SiPM) and an FPGA-based readout, with fiber geometry optimized to minimize perturbations to a clinical proton beam, as confirmed through measurements at the Huntsman Cancer Institute (HCI). Results: Tests using a portable X-ray unit demonstrated a strong correlation between integrated charge and delivered dose (up to ∼35 mrem s-1) and showed that the detector can respond on nanosecond timescales, enabling rapid safety interlock triggering with minimal latency. Conclusion: Preliminary proton irradiations at HCI further indicated that the device can resolve individual beam pulses, a capability valuable for both FLASH research and conventional radiotherapy. Advances in Knowledge: These results highlight the need for continued refinement of the experimental setup, readout electronics, and detector performance to fully realize real-time, in situ dose and pulse monitoring. (© The Author(s) 2026. Published by Oxford University Press on behalf of the British Institute of Radiology.) |
| References: | Med Phys. 2024 Nov;51(11):8411-8422. (PMID: 39153223) JAMA Oncol. 2023 Jan 1;9(1):62-69. (PMID: 36273324) Phys Med Biol. 2021 Jun 08;66(12):. (PMID: 33906166) Br J Radiol. 2020 Mar;93(1107):20190807. (PMID: 32003574) Phys Med. 2020 Oct;78:71-82. (PMID: 32947086) Br J Radiol. 2020 Mar;93(1107):20190598. (PMID: 31782941) Int J Radiat Oncol Biol Phys. 2017 Jan 1;97(1):195-203. (PMID: 27816362) Med Phys. 2009 May;36(5):1736-43. (PMID: 19544791) Clin Cancer Res. 2019 Jan 1;25(1):3-5. (PMID: 30093447) Med Phys. 2020 Dec;47(12):6396-6404. (PMID: 32910460) Med Phys. 2021 Nov;48(11):7382-7398. (PMID: 34586641) Phys Med Biol. 2020 Dec 04;65(23):23TR03. (PMID: 32721941) Cancers (Basel). 2023 Jul 30;15(15):. (PMID: 37568699) Int J Radiat Oncol Biol Phys. 2020 Feb 1;106(2):440-448. (PMID: 31928642) Radiother Oncol. 2019 Oct;139:46-50. (PMID: 31266652) Open Access Maced J Med Sci. 2017 Jul 18;5(4):521-525. (PMID: 28785349) Med Phys. 2017 Mar;44(3):1157-1167. (PMID: 28094853) Int J Mol Sci. 2020 Sep 05;21(18):. (PMID: 32899466) Sci Rep. 2020 Jun 3;10(1):9089. (PMID: 32493952) J Appl Clin Med Phys. 2024 Sep;25(9):e14486. (PMID: 39137008) Phys Med. 2023 Oct;114:103147. (PMID: 37804712) Phys Med Biol. 2021 Apr 15;66(8):. (PMID: 33571973) Sci Transl Med. 2014 Jul 16;6(245):245ra93. (PMID: 25031268) Phys Med Biol. 2021 Jun 30;66(13):. (PMID: 34015774) Cancer Radiother. 2020 Oct;24(6-7):691-698. (PMID: 32753235) Phys Med Biol. 2022 Apr 15;67(9):. (PMID: 35313290) Med Phys. 2018 Apr;45(4):1782-1789. (PMID: 29446078) Med Phys. 2021 May;48(5):2673-2681. (PMID: 33730367) Radiother Oncol. 2019 Oct;139:18-22. (PMID: 31303340) Med Phys. 2019 Dec;46(12):5690-5695. (PMID: 31600830) Sci Rep. 2018 Mar 6;8(1):4100. (PMID: 29511282) Phys Med. 2022 Nov;103:127-137. (PMID: 36302279) Med Phys. 2021 Jul;48(7):3948-3957. (PMID: 33843065) Radiother Oncol. 2019 Oct;139:40-45. (PMID: 30755324) |
| Contributed Indexing: | Keywords: FLASH; GEANT4; dosimetry; proton; radiotherapy |
| Entry Date(s): | Date Created: 20260619 Date Completed: 20260929 Latest Revision: 20261001 |
| Update Code: | 20261001 |
| PubMed Central ID: | PMC13623240 |
| DOI: | 10.1093/bjr/tqag152 |
| PMID: | 42319906 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1748-880X |
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| DOI: | 10.1093/bjr/tqag152 |