Academic Journal
Προβολή σε EDS

Development of in situ dosimetry for FLASH proton radiotherapy via organic scintillating fibers.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Development of in situ dosimetry for FLASH proton radiotherapy via organic scintillating fibers.
Συγγραφείς: Olson C; Department of Civil and Environmental Engineering, University of Utah Nuclear Engineering Program, Salt Lake City, UT 84112, United States., Strong J; Department of Civil and Environmental Engineering, University of Utah Nuclear Engineering Program, Salt Lake City, UT 84112, United States., Paxton A; Department of Radiation Oncology, Huntsman Cancer Institute, Salt Lake City, UT 84112, United States., Nelson G; Department of Radiation Oncology, Huntsman Cancer Institute, Salt Lake City, UT 84112, United States., Cazalas E; Department of Civil and Environmental Engineering, University of Utah Nuclear Engineering Program, Salt Lake City, UT 84112, United States.
Πηγή: The British journal of radiology [Br J Radiol] 2026 Oct 01; Vol. 99 (1186), pp. 2117-2128.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Oxford University Press Country of Publication: England NLM ID: 0373125 Publication Model: Print Cited Medium: Internet ISSN: 1748-880X (Electronic) Linking ISSN: 00071285 NLM ISO Abbreviation: Br J Radiol Subsets: MEDLINE
Imprint Name(s): Publication: January 2024- : [Oxford] : Oxford University Press
Original Publication: London, British Institute of Radiology.
Ιατρικοί όροι (MeSH): Proton Therapy*/instrumentation , Proton Therapy*/methods , Radiometry*/instrumentation , Radiometry*/methods , Scintillation Counting*/instrumentation, Equipment Design ; Radiotherapy Dosage ; Humans
Περίληψη: Objectives: This work presents the design, development, and initial proof-of-concept testing of a dosimetry device intended for FLASH radiotherapy.
Methods: The system incorporates organic scintillating fibers coupled to a silicon photomultiplier (SiPM) and an FPGA-based readout, with fiber geometry optimized to minimize perturbations to a clinical proton beam, as confirmed through measurements at the Huntsman Cancer Institute (HCI).
Results: Tests using a portable X-ray unit demonstrated a strong correlation between integrated charge and delivered dose (up to ∼35 mrem s-1) and showed that the detector can respond on nanosecond timescales, enabling rapid safety interlock triggering with minimal latency.
Conclusion: Preliminary proton irradiations at HCI further indicated that the device can resolve individual beam pulses, a capability valuable for both FLASH research and conventional radiotherapy.
Advances in Knowledge: These results highlight the need for continued refinement of the experimental setup, readout electronics, and detector performance to fully realize real-time, in situ dose and pulse monitoring.
(© The Author(s) 2026. Published by Oxford University Press on behalf of the British Institute of Radiology.)
References: Med Phys. 2024 Nov;51(11):8411-8422. (PMID: 39153223)
JAMA Oncol. 2023 Jan 1;9(1):62-69. (PMID: 36273324)
Phys Med Biol. 2021 Jun 08;66(12):. (PMID: 33906166)
Br J Radiol. 2020 Mar;93(1107):20190807. (PMID: 32003574)
Phys Med. 2020 Oct;78:71-82. (PMID: 32947086)
Br J Radiol. 2020 Mar;93(1107):20190598. (PMID: 31782941)
Int J Radiat Oncol Biol Phys. 2017 Jan 1;97(1):195-203. (PMID: 27816362)
Med Phys. 2009 May;36(5):1736-43. (PMID: 19544791)
Clin Cancer Res. 2019 Jan 1;25(1):3-5. (PMID: 30093447)
Med Phys. 2020 Dec;47(12):6396-6404. (PMID: 32910460)
Med Phys. 2021 Nov;48(11):7382-7398. (PMID: 34586641)
Phys Med Biol. 2020 Dec 04;65(23):23TR03. (PMID: 32721941)
Cancers (Basel). 2023 Jul 30;15(15):. (PMID: 37568699)
Int J Radiat Oncol Biol Phys. 2020 Feb 1;106(2):440-448. (PMID: 31928642)
Radiother Oncol. 2019 Oct;139:46-50. (PMID: 31266652)
Open Access Maced J Med Sci. 2017 Jul 18;5(4):521-525. (PMID: 28785349)
Med Phys. 2017 Mar;44(3):1157-1167. (PMID: 28094853)
Int J Mol Sci. 2020 Sep 05;21(18):. (PMID: 32899466)
Sci Rep. 2020 Jun 3;10(1):9089. (PMID: 32493952)
J Appl Clin Med Phys. 2024 Sep;25(9):e14486. (PMID: 39137008)
Phys Med. 2023 Oct;114:103147. (PMID: 37804712)
Phys Med Biol. 2021 Apr 15;66(8):. (PMID: 33571973)
Sci Transl Med. 2014 Jul 16;6(245):245ra93. (PMID: 25031268)
Phys Med Biol. 2021 Jun 30;66(13):. (PMID: 34015774)
Cancer Radiother. 2020 Oct;24(6-7):691-698. (PMID: 32753235)
Phys Med Biol. 2022 Apr 15;67(9):. (PMID: 35313290)
Med Phys. 2018 Apr;45(4):1782-1789. (PMID: 29446078)
Med Phys. 2021 May;48(5):2673-2681. (PMID: 33730367)
Radiother Oncol. 2019 Oct;139:18-22. (PMID: 31303340)
Med Phys. 2019 Dec;46(12):5690-5695. (PMID: 31600830)
Sci Rep. 2018 Mar 6;8(1):4100. (PMID: 29511282)
Phys Med. 2022 Nov;103:127-137. (PMID: 36302279)
Med Phys. 2021 Jul;48(7):3948-3957. (PMID: 33843065)
Radiother Oncol. 2019 Oct;139:40-45. (PMID: 30755324)
Contributed Indexing: Keywords: FLASH; GEANT4; dosimetry; proton; radiotherapy
Entry Date(s): Date Created: 20260619 Date Completed: 20260929 Latest Revision: 20261001
Update Code: 20261001
PubMed Central ID: PMC13623240
DOI: 10.1093/bjr/tqag152
PMID: 42319906
Βάση Δεδομένων: MEDLINE
FullText Text:
  Availability: 0
Header DbId: cmedm
DbLabel: MEDLINE
An: 42319906
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Development of in situ dosimetry for FLASH proton radiotherapy via organic scintillating fibers.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Olson+C%22">Olson C</searchLink>; Department of Civil and Environmental Engineering, University of Utah Nuclear Engineering Program, Salt Lake City, UT 84112, United States.<br /><searchLink fieldCode="AU" term="%22Strong+J%22">Strong J</searchLink>; Department of Civil and Environmental Engineering, University of Utah Nuclear Engineering Program, Salt Lake City, UT 84112, United States.<br /><searchLink fieldCode="AU" term="%22Paxton+A%22">Paxton A</searchLink>; Department of Radiation Oncology, Huntsman Cancer Institute, Salt Lake City, UT 84112, United States.<br /><searchLink fieldCode="AU" term="%22Nelson+G%22">Nelson G</searchLink>; Department of Radiation Oncology, Huntsman Cancer Institute, Salt Lake City, UT 84112, United States.<br /><searchLink fieldCode="AU" term="%22Cazalas+E%22">Cazalas E</searchLink>; Department of Civil and Environmental Engineering, University of Utah Nuclear Engineering Program, Salt Lake City, UT 84112, United States.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%220373125%22">The British journal of radiology</searchLink> [Br J Radiol] 2026 Oct 01; Vol. 99 (1186), pp. 2117-2128.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0373125 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1748-880X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200071285%22">00071285 </searchLink><i>NLM ISO Abbreviation: </i>Br J Radiol <i>Subsets: </i>MEDLINE
– Name: PublisherInfo
  Label: Imprint Name(s)
  Group: PubInfo
  Data: <i>Publication</i>: January 2024- : [Oxford] : Oxford University Press<br /><i>Original Publication</i>: London, British Institute of Radiology.
– Name: SubjectMESH
  Label: MeSH Terms
  Group: Su
  Data: <searchLink fieldCode="MM" term="%22Proton+Therapy%22">Proton Therapy*</searchLink>/<searchLink fieldCode="MM" term="%22Proton+Therapy+instrumentation%22">instrumentation</searchLink> <br /><searchLink fieldCode="MM" term="%22Proton+Therapy%22">Proton Therapy*</searchLink>/<searchLink fieldCode="MM" term="%22Proton+Therapy+methods%22">methods</searchLink> <br /><searchLink fieldCode="MM" term="%22Radiometry%22">Radiometry*</searchLink>/<searchLink fieldCode="MM" term="%22Radiometry+instrumentation%22">instrumentation</searchLink> <br /><searchLink fieldCode="MM" term="%22Radiometry%22">Radiometry*</searchLink>/<searchLink fieldCode="MM" term="%22Radiometry+methods%22">methods</searchLink> <br /><searchLink fieldCode="MM" term="%22Scintillation+Counting%22">Scintillation Counting*</searchLink>/<searchLink fieldCode="MM" term="%22Scintillation+Counting+instrumentation%22">instrumentation</searchLink><br /><searchLink fieldCode="MH" term="%22Equipment+Design%22">Equipment Design</searchLink> ; <searchLink fieldCode="MH" term="%22Radiotherapy+Dosage%22">Radiotherapy Dosage</searchLink> ; <searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objectives: This work presents the design, development, and initial proof-of-concept testing of a dosimetry device intended for FLASH radiotherapy.<br />Methods: The system incorporates organic scintillating fibers coupled to a silicon photomultiplier (SiPM) and an FPGA-based readout, with fiber geometry optimized to minimize perturbations to a clinical proton beam, as confirmed through measurements at the Huntsman Cancer Institute (HCI).<br />Results: Tests using a portable X-ray unit demonstrated a strong correlation between integrated charge and delivered dose (up to ∼35 mrem s-1) and showed that the detector can respond on nanosecond timescales, enabling rapid safety interlock triggering with minimal latency.<br />Conclusion: Preliminary proton irradiations at HCI further indicated that the device can resolve individual beam pulses, a capability valuable for both FLASH research and conventional radiotherapy.<br />Advances in Knowledge: These results highlight the need for continued refinement of the experimental setup, readout electronics, and detector performance to fully realize real-time, in situ dose and pulse monitoring.<br /> (© The Author(s) 2026. Published by Oxford University Press on behalf of the British Institute of Radiology.)
– Name: Ref
  Label: References
  Group: RefInfo
  Data: Med Phys. 2024 Nov;51(11):8411-8422. (PMID: <searchLink fieldCode="PM" term="%2239153223%22">39153223)</searchLink><br />JAMA Oncol. 2023 Jan 1;9(1):62-69. (PMID: <searchLink fieldCode="PM" term="%2236273324%22">36273324)</searchLink><br />Phys Med Biol. 2021 Jun 08;66(12):. (PMID: <searchLink fieldCode="PM" term="%2233906166%22">33906166)</searchLink><br />Br J Radiol. 2020 Mar;93(1107):20190807. (PMID: <searchLink fieldCode="PM" term="%2232003574%22">32003574)</searchLink><br />Phys Med. 2020 Oct;78:71-82. (PMID: <searchLink fieldCode="PM" term="%2232947086%22">32947086)</searchLink><br />Br J Radiol. 2020 Mar;93(1107):20190598. (PMID: <searchLink fieldCode="PM" term="%2231782941%22">31782941)</searchLink><br />Int J Radiat Oncol Biol Phys. 2017 Jan 1;97(1):195-203. (PMID: <searchLink fieldCode="PM" term="%2227816362%22">27816362)</searchLink><br />Med Phys. 2009 May;36(5):1736-43. (PMID: <searchLink fieldCode="PM" term="%2219544791%22">19544791)</searchLink><br />Clin Cancer Res. 2019 Jan 1;25(1):3-5. (PMID: <searchLink fieldCode="PM" term="%2230093447%22">30093447)</searchLink><br />Med Phys. 2020 Dec;47(12):6396-6404. (PMID: <searchLink fieldCode="PM" term="%2232910460%22">32910460)</searchLink><br />Med Phys. 2021 Nov;48(11):7382-7398. (PMID: <searchLink fieldCode="PM" term="%2234586641%22">34586641)</searchLink><br />Phys Med Biol. 2020 Dec 04;65(23):23TR03. (PMID: <searchLink fieldCode="PM" term="%2232721941%22">32721941)</searchLink><br />Cancers (Basel). 2023 Jul 30;15(15):. (PMID: <searchLink fieldCode="PM" term="%2237568699%22">37568699)</searchLink><br />Int J Radiat Oncol Biol Phys. 2020 Feb 1;106(2):440-448. (PMID: <searchLink fieldCode="PM" term="%2231928642%22">31928642)</searchLink><br />Radiother Oncol. 2019 Oct;139:46-50. (PMID: <searchLink fieldCode="PM" term="%2231266652%22">31266652)</searchLink><br />Open Access Maced J Med Sci. 2017 Jul 18;5(4):521-525. (PMID: <searchLink fieldCode="PM" term="%2228785349%22">28785349)</searchLink><br />Med Phys. 2017 Mar;44(3):1157-1167. (PMID: <searchLink fieldCode="PM" term="%2228094853%22">28094853)</searchLink><br />Int J Mol Sci. 2020 Sep 05;21(18):. (PMID: <searchLink fieldCode="PM" term="%2232899466%22">32899466)</searchLink><br />Sci Rep. 2020 Jun 3;10(1):9089. (PMID: <searchLink fieldCode="PM" term="%2232493952%22">32493952)</searchLink><br />J Appl Clin Med Phys. 2024 Sep;25(9):e14486. (PMID: <searchLink fieldCode="PM" term="%2239137008%22">39137008)</searchLink><br />Phys Med. 2023 Oct;114:103147. (PMID: <searchLink fieldCode="PM" term="%2237804712%22">37804712)</searchLink><br />Phys Med Biol. 2021 Apr 15;66(8):. (PMID: <searchLink fieldCode="PM" term="%2233571973%22">33571973)</searchLink><br />Sci Transl Med. 2014 Jul 16;6(245):245ra93. (PMID: <searchLink fieldCode="PM" term="%2225031268%22">25031268)</searchLink><br />Phys Med Biol. 2021 Jun 30;66(13):. (PMID: <searchLink fieldCode="PM" term="%2234015774%22">34015774)</searchLink><br />Cancer Radiother. 2020 Oct;24(6-7):691-698. (PMID: <searchLink fieldCode="PM" term="%2232753235%22">32753235)</searchLink><br />Phys Med Biol. 2022 Apr 15;67(9):. (PMID: <searchLink fieldCode="PM" term="%2235313290%22">35313290)</searchLink><br />Med Phys. 2018 Apr;45(4):1782-1789. (PMID: <searchLink fieldCode="PM" term="%2229446078%22">29446078)</searchLink><br />Med Phys. 2021 May;48(5):2673-2681. (PMID: <searchLink fieldCode="PM" term="%2233730367%22">33730367)</searchLink><br />Radiother Oncol. 2019 Oct;139:18-22. (PMID: <searchLink fieldCode="PM" term="%2231303340%22">31303340)</searchLink><br />Med Phys. 2019 Dec;46(12):5690-5695. (PMID: <searchLink fieldCode="PM" term="%2231600830%22">31600830)</searchLink><br />Sci Rep. 2018 Mar 6;8(1):4100. (PMID: <searchLink fieldCode="PM" term="%2229511282%22">29511282)</searchLink><br />Phys Med. 2022 Nov;103:127-137. (PMID: <searchLink fieldCode="PM" term="%2236302279%22">36302279)</searchLink><br />Med Phys. 2021 Jul;48(7):3948-3957. (PMID: <searchLink fieldCode="PM" term="%2233843065%22">33843065)</searchLink><br />Radiother Oncol. 2019 Oct;139:40-45. (PMID: <searchLink fieldCode="PM" term="%2230755324%22">30755324)</searchLink>
– Name: SubjectMinor
  Label: Contributed Indexing
  Group:
  Data: <i>Keywords: </i>FLASH; GEANT4; dosimetry; proton; radiotherapy
– Name: DateEntry
  Label: Entry Date(s)
  Group: Date
  Data: <i>Date Created: </i>20260619 <i>Date Completed: </i>20260929 <i>Latest Revision: </i>20261001
– Name: DateUpdate
  Label: Update Code
  Group: Date
  Data: 20261001
– Name: PubmedCentralID
  Label: PubMed Central ID
  Group: ID
  Data: PMC13623240
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1093/bjr/tqag152
– Name: AN
  Label: PMID
  Group: ID
  Data: 42319906
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=42319906
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1093/bjr/tqag152
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 2117
    Subjects:
      – SubjectFull: Equipment Design
        Type: general
      – SubjectFull: Radiotherapy Dosage
        Type: general
      – SubjectFull: Humans
        Type: general
      – SubjectFull: Proton Therapy instrumentation
        Type: general
      – SubjectFull: Proton Therapy methods
        Type: general
      – SubjectFull: Radiometry instrumentation
        Type: general
      – SubjectFull: Radiometry methods
        Type: general
      – SubjectFull: Scintillation Counting instrumentation
        Type: general
    Titles:
      – TitleFull: Development of in situ dosimetry for FLASH proton radiotherapy via organic scintillating fibers.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Olson C
      – PersonEntity:
          Name:
            NameFull: Strong J
      – PersonEntity:
          Name:
            NameFull: Paxton A
      – PersonEntity:
          Name:
            NameFull: Nelson G
      – PersonEntity:
          Name:
            NameFull: Cazalas E
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 10
              Text: 2026 Oct 01
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1748-880X
          Numbering:
            – Type: volume
              Value: 99
            – Type: issue
              Value: 1186
          Titles:
            – TitleFull: The British journal of radiology
              Type: main
ResultId 1