Academic Journal
Clinical Management of Helicobacter Infection in Captive Baboons (Papio anubis and Papio hamadryas), and Isolation and Molecular Characterization of Three Novel Helicobacter Species.
| Τίτλος: | Clinical Management of Helicobacter Infection in Captive Baboons (Papio anubis and Papio hamadryas), and Isolation and Molecular Characterization of Three Novel Helicobacter Species. |
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| Συγγραφείς: | Jimenez IA; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Lunger C; Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Crim MJ; IDEXX BioAnalytics, Columbia, Missouri, USA., Primm SL; IDEXX BioAnalytics, Columbia, Missouri, USA., Mannion A; Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Crilly NP; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Hopper LM; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Research Animal Resources, Johns Hopkins University, Baltimore, Maryland, USA., Thurman LG; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Vasquez LL; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Brayton C; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Feng Y; Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Fox JG; Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Shen Z; Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Izzi JM; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. |
| Πηγή: | Journal of medical primatology [J Med Primatol] 2026 Aug; Vol. 55 (4), pp. e70095. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Wiley Country of Publication: Denmark NLM ID: 0320626 Publication Model: Print Cited Medium: Internet ISSN: 1600-0684 (Electronic) Linking ISSN: 00472565 NLM ISO Abbreviation: J Med Primatol Subsets: MEDLINE |
| Imprint Name(s): | Publication: Copenhagen : Wiley Original Publication: Basel, New York, Karger. |
| Ιατρικοί όροι (MeSH): | Helicobacter Infections*/veterinary , Helicobacter Infections*/drug therapy , Helicobacter Infections*/microbiology , Helicobacter*/isolation & purification , Helicobacter*/genetics , Helicobacter*/classification , Monkey Diseases*/microbiology , Monkey Diseases*/drug therapy , Anti-Bacterial Agents*/therapeutic use , Anti-Bacterial Agents*/administration & dosage , Papio hamadryas* , Papio anubis*, Amoxicillin/therapeutic use ; Amoxicillin/administration & dosage ; Omeprazole/therapeutic use ; Omeprazole/administration & dosage ; Clarithromycin/therapeutic use ; Clarithromycin/administration & dosage ; Feces/microbiology ; Polymerase Chain Reaction/veterinary ; Drug Therapy, Combination/veterinary ; Animals ; Female ; Male |
| Περίληψη: | Background: Helicobacter spp. are gastric or enterohepatic bacteria that can be commensal, opportunistic, or pathogenic. Few studies have evaluated Helicobacter spp. in baboons. Methods: Twenty-seven captive baboons were surveyed for Helicobacter spp. by fecal PCR, and a subset evaluated by culture. Nine baboons were treated with oral "triple therapy" with clarithromycin (10 mg/kg), amoxicillin (10 mg/kg), and omeprazole (20 mg) once daily for 10 days. Results: All baboons were positive for Helicobacter spp., including H. macacae (78%), H. suis (19%), and H. pylori (15%). Three novel Helicobacter species were identified by whole genomic sequencing, for which we propose the names Helicobacter papionis, H. simiae, and H. papionifaecis. Treatment was safe and effective for H. pylori, H. suis, and H. macacae, but did not eliminate the novel Helicobacter spp. Conclusions: Species-specific assays should guide treatment of Helicobacter spp. infections in baboons. Further epidemiologic studies are needed to inform clinical management. (© 2026 The Author(s). Journal of Medical Primatology published by John Wiley & Sons Ltd.) |
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| Grant Information: | Johns Hopkins University; R35 CA210088 United States NH NIH HHS; 1R01 CA281732-01 United States NH NIH HHS; T32 OD011089 United States NH NIH HHS; IDEXX BioAnalytics; Massachusetts Institute of Technology |
| Contributed Indexing: | Keywords: captive management; enterohepatic Helicobacter; fecal PCR; surveillance |
| Substance Nomenclature: | 0 (Anti-Bacterial Agents) 804826J2HU (Amoxicillin) KG60484QX9 (Omeprazole) H1250JIK0A (Clarithromycin) |
| Entry Date(s): | Date Created: 20260619 Date Completed: 20260619 Latest Revision: 20260813 |
| Update Code: | 20260814 |
| PubMed Central ID: | PMC13280779 |
| DOI: | 10.1111/jmp.70095 |
| PMID: | 42318630 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1600-0684 |
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| DOI: | 10.1111/jmp.70095 |