Λεπτομέρειες βιβλιογραφικής εγγραφής
| Τίτλος: |
Influence of fungi on epithelial homeostasis and role in inflammatory diseases. |
| Συγγραφείς: |
Peterson LF; Department of Pathology & Laboratory Medicine, University of Rochester, Rochester, New York, USA., Wang J; Department of Dermatology, University of Rochester, Rochester, New York, USA., Gow NAR; Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter, United Kingdom., LeibundGut-Landmann S; Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter, United Kingdom.; Section of Immunology, Vetsuisse Faculty, University of Zürich, Zürich, Switzerland.; Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland., Brewer MG; Department of Dermatology, University of Rochester, Rochester, New York, USA. |
| Πηγή: |
Clinical microbiology reviews [Clin Microbiol Rev] 2026 Sep 10; Vol. 39 (3), pp. e0031925. Date of Electronic Publication: 2026 Jun 18. |
| Τύπος έκδοσης: |
Journal Article; Review |
| Γλώσσα: |
English |
| Στοιχεία περιοδικού: |
Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 8807282 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6618 (Electronic) Linking ISSN: 08938512 NLM ISO Abbreviation: Clin Microbiol Rev Subsets: MEDLINE |
| Imprint Name(s): |
Original Publication: [Washington, DC] : American Society for Microbiology, [c1988- |
| Ιατρικοί όροι (MeSH): |
Fungi*/pathogenicity , Fungi*/physiology , Dermatomycoses*/microbiology , Inflammation*/microbiology , Homeostasis* , Host-Pathogen Interactions*, Skin/microbiology ; Skin/immunology ; Humans ; Skin Microbiome |
| Περίληψη: |
SUMMARYThe skin harbors a diverse fungal community that contributes to both epidermal homeostasis and inflammatory disease. Historically, studies of cutaneous fungi focused primarily on opportunistic infections in immunocompromised hosts. Advances in sequencing technologies and metagenomic analyses have revealed that commensal yeasts of the skin microbiome likely influence host physiology and cutaneous disease severity. In this review, we summarize the current knowledge of host-fungal interactions at the skin epithelium, with particular emphasis on the yeast genera Malassezia and Candida. We discuss how fungal colonization shapes epidermal biology through direct interactions with keratinocytes and immune cells, highlighting fungal virulence factors such as secreted proteases and candidalysin, as well as host-sensing pathways. We further examine how these interactions contribute to inflammatory skin diseases, particularly atopic dermatitis and psoriasis, and how fungi participate in polymicrobial networks with bacteria and viruses to alter susceptibility to infection. Finally, we discuss how emerging therapeutic strategies change the fungal composition on skin. These advances suggest the importance of fungi as active regulators of skin immunity and emphasize key knowledge gaps that need to be addressed in future studies to better understand how they contribute to cutaneous diseases. |
| Competing Interests: |
The authors declare no conflict of interest. |
| Grant Information: |
T32 AI118689 United States NH NIH HHS; LF-OC-22_001060 LEO Fondet; 310030_189255 Switzerland SNSF_ Swiss National Science Foundation; 310030E_219182 Switzerland SNSF_ Swiss National Science Foundation; MR/V033417/1 Medical Research Council Centre for Medical Mycology; 200208 United Kingdom WT_ Wellcome Trust; 215599 United Kingdom WT_ Wellcome Trust; 224323 United Kingdom WT_ Wellcome Trust; MR/M026663/2 United Kingdom MRC_ Medical Research Council; MR/Y002164/1 United Kingdom MRC_ Medical Research Council; APP57173- UKRI1405 United Kingdom MRC_ Medical Research Council; MR/N006364/2 Medical Research Council Centre for Medical Mycology; NIHR203320 NIHR Exeter Biomedical Research Centre |
| Contributed Indexing: |
Keywords: Candida; host-pathogen interactions; immune response; skin microbiota; yeasts |
| Entry Date(s): |
Date Created: 20260618 Date Completed: 20260910 Latest Revision: 20260912 |
| Update Code: |
20260912 |
| PubMed Central ID: |
PMC13560646 |
| DOI: |
10.1128/cmr.00319-25 |
| PMID: |
42312840 |
| Βάση Δεδομένων: |
MEDLINE |