Academic Journal
Association between endogenous oxytocin levels and live birth rates following fresh embryo transfer: a prospective cohort study.
| Τίτλος: | Association between endogenous oxytocin levels and live birth rates following fresh embryo transfer: a prospective cohort study. |
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| Συγγραφείς: | Zhou R; Center for Reproductive Medicine, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China.; Women and Children's Hospital, Southern University of Science and Technology, Shenzhen, China., Wang Z; Center for Reproductive Medicine, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China., Zhu Z; School of Public Health, Sun Yat-sen University, Guangzhou, China., Dong M; Center for Reproductive Medicine, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China.; Women and Children's Hospital, Southern University of Science and Technology, Shenzhen, China., Wang J; Center for Reproductive Medicine, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China., Huang L; Center for Reproductive Medicine, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China.; Women and Children's Hospital, Southern University of Science and Technology, Shenzhen, China., Qi Q; Center for Reproductive Medicine, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China.; Women and Children's Hospital, Southern University of Science and Technology, Shenzhen, China., Zhang X; Center for Reproductive Medicine, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China.; Women and Children's Hospital, Southern University of Science and Technology, Shenzhen, China., Liu F; Center for Reproductive Medicine, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China.; Women and Children's Hospital, Southern University of Science and Technology, Shenzhen, China. |
| Πηγή: | Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2026 Jun 02; Vol. 17, pp. 1850346. Date of Electronic Publication: 2026 Jun 02 (Print Publication: 2026). |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [Lausanne : Frontiers Research Foundation] |
| Ιατρικοί όροι (MeSH): | Oxytocin*/blood , Oxytocin*/metabolism , Oxytocin*/analysis , Embryo Transfer*/methods , Follicular Fluid*/metabolism , Follicular Fluid*/chemistry , Live Birth*/epidemiology , Birth Rate*, Fertilization in Vitro/methods ; Humans ; Female ; Pregnancy ; Prospective Studies ; Adult ; Ovulation Induction ; Pregnancy Rate |
| Περίληψη: | Objective: To investigate the associations between serum and follicular fluid oxytocin levels and live birth rate (LBR) in IVF cycles, and to examine their correlations with clinical parameters. Design: Prospective cohort study. Methods: A total of 680 infertile patients undergoing IVF cycles between October 2024 and January 2025 were enrolled for serum and follicular fluid oxytocin measurement. The associations between serum and follicular fluid oxytocin levels and LBR were assessed using three statistical approaches: multivariable logistic regression, inverse probability weighting, and a double robust model. Smoothed curve fitting was employed to explore the relationships between oxytocin levels and LBR. Additionally, Spearman correlation analysis was performed to examine the associations between oxytocin levels and key clinical parameters. Results: Serum oxytocin demonstrated a negative linear association with LBR (p-nonlinear = 0.911), whereas follicular fluid oxytocin showed a positive association (p-nonlinear = 0.425). In the double robust model, each 100 pg/mL increase in serum oxytocin decreased the likelihood of live birth by 37% (95% CI: 25%-47%), whereas a corresponding increase in follicular fluid oxytocin improved it by 18% (95% CI: 2%-37%). Additionally, serum oxytocin correlated positively with triglycerides (r = 0.294), LDL-C (r = 0.165), and insulin (r = 0.257), but negatively with HDL-C (r = -0.167). Conversely, follicular fluid oxytocin correlated positively with ovarian response markers, including hCG-trigger day estradiol (r = 0.229) and oocytes retrieved (r = 0.248). Conclusion: Higher basal serum oxytocin prior to ovarian stimulation is negatively associated with LBR following fresh embryo transfer, whereas elevated follicular fluid oxytocin correlates with improved ovarian response. (Copyright © 2026 Zhou, Wang, Zhu, Dong, Wang, Huang, Qi, Zhang and Liu.) |
| Competing Interests: | The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. |
| Contributed Indexing: | Keywords: fresh embryo transfer; in vitro fertilization; live birth rate; ovarian response; oxytocin |
| Substance Nomenclature: | 50-56-6 (Oxytocin) |
| Entry Date(s): | Date Created: 20260618 Date Completed: 20260618 Latest Revision: 20260618 |
| Update Code: | 20260618 |
| PubMed Central ID: | PMC13268967 |
| DOI: | 10.3389/fendo.2026.1850346 |
| PMID: | 42312200 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1664-2392 |
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| DOI: | 10.3389/fendo.2026.1850346 |