Academic Journal
Choroidal thickness on optical coherence tomography as a longitudinal predictor of visual outcomes in intermediate uveitis.
| Τίτλος: | Choroidal thickness on optical coherence tomography as a longitudinal predictor of visual outcomes in intermediate uveitis. |
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| Συγγραφείς: | Biswal S; Department of Medical Retina and Uvea, Sankara Eye Hospital, Shivamogga, India., Sagar P; Department of Medical Retina and Uvea, Sankara Eye Hospital, Shivamogga, India., Just MD; Department of Ophthalmology, University Hospital Bonn, University of Bonn, Bonn, Germany., Merten NR; Department of Ophthalmology, University Hospital Bonn, University of Bonn, Bonn, Germany., Berger M; Core Facility Biostatistics, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany., Terheyden JH; Department of Ophthalmology, University Hospital Bonn, University of Bonn, Bonn, Germany., Schmid M; Department of Medical Biometry, Informatics and Epidemiology, University Hospital Bonn, University of Bonn, Bonn, Germany., Holz FG; Department of Ophthalmology, University Hospital Bonn, University of Bonn, Bonn, Germany., Finger RP; Department of Ophthalmology, University Hospital Bonn, University of Bonn, Bonn, Germany.; Department of Ophthalmology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Wintergerst MWM; Department of Ophthalmology, University Hospital Bonn, University of Bonn, Bonn, Germany. maximilian.wintergerst@ukbonn.de.; Augenzentrum Grischun, Chur, Switzerland. maximilian.wintergerst@ukbonn.de.; Department of Ophthalmology, University Hospital Bonn, Ernst-Abbe-Straße 2 |, 53127, Bonn, Germany. maximilian.wintergerst@ukbonn.de. |
| Πηγή: | Scientific reports [Sci Rep] 2026 Jun 17; Vol. 16 (1). Date of Electronic Publication: 2026 Jun 17. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : Nature Publishing Group, copyright 2011- |
| Ιατρικοί όροι (MeSH): | Tomography, Optical Coherence*/methods , Choroid*/pathology , Choroid*/diagnostic imaging , Uveitis, Intermediate*/diagnostic imaging , Uveitis, Intermediate*/pathology , Uveitis, Intermediate*/physiopathology , Visual Acuity*, Humans ; Female ; Male ; Prognosis ; Middle Aged ; Adult |
| Περίληψη: | To assess longitudinal changes in subfoveal choroidal thickness (SFCT) and mean choroidal thickness (MCT) in intermediate uveitis, eyes with at least one follow-up visit were included. These eyes were stratified into clinically worsened, stable, or improved based on changes in clinical parameters including Standardization of Uveitis Nomenclature (SUN) classification, to evaluate their prognostic value for future best-corrected visual acuity (BCVA) and central retinal thickness (CRT). Spectral domain optical coherence tomography (Heidelberg Engineering, Germany) was used to image the central macula. SFCT, MCT, and CRT were measured manually within the central 1 mm. Mixed-effects regression analysis controlling for age and sex was used to evaluate the prognostic value of SFCT and MCT regarding future BCVA and CRT. A total of 91 eyes from 52 patients were included in the analysis. While 12 eyes worsened, 62 remained stable, and 17 improved. Choroidal thickness remained stable over time, with no significant differences in SFCT or MCT change between clinical groups (p > 0.5 for all). When controlling for age and sex, both the baseline SFCT (estimate = -0.35 × 10- ³ logMAR per µm, p = 0.040) and MCT (estimate = -0.42 × 10-³ logMAR per µm, p = 0.018) were prognostic for future BCVA. MCT, but not SFCT, was significantly associated with future CRT (estimate = -0.15 μm per µm, p = 0.010 vs. -0.13 μm per µm, p = 0.140). Choroidal thickness in terms of baseline SFCT and MCT is prognostic of future BCVA and could serve as a prognostic structural biomarker for intermediate uveitis. (© 2026. The Author(s).) |
| Competing Interests: | Declarations. Competing interests: The authors declare no competing interests. Financial disclosures: PS: None. SB: None. MDJ: None. NRM: None. MB: None. JHT: Bayer (C), Novartis (R), Okko (R), Zeiss (F). MS: None. FGH: 4D Molecular Therapeutics (R), Abbvie (C), Acucela (C), Acucela (R), Alcon (C), Alexion (C), Allergan (R), Annexon (R, C), Apellis (R, C), Astellas (R, C), Bayer (R, C), Bioeq (R), Biogen (C), Boehringer-Ingelheim (C), Centervue (R), Cirrus (C), Galimedix (C), Genentech/Roche (R, C), Geuder (R), Grayburg Vision (C), Heidelberg Engineering (R, C), Lin Bioscience (C), Merck (C), NightStar (R), Novartis (R, C), OCULIS (C), Okuvision (C), Opthea(C), Oxurion (C), Sanofi (C), Science (R, C), Stealth Biotherapeutics (C), Topcon (C), Zeiss (R, C). RPF: Alimera (C), Apellis (C), Astellas (C), Bayer (R, C), Biogen (C), Biogen (R), Böhringer-Ingelheim (C), Heidelberg Engineering (C), Novartis (C), ODOS (C) Opthea (C), ProGenerika (C), Roche (R), Roche/Genentech (C), Santen (C), Stada Pharm (C). MWMW: ASKIN & CO GmbH (R), Bayer AG (R), Berlin-Chemie AG (R, F), Carl Zeiss Meditec (F), CenterVue SpA (F), D-Eye Srl (F), DigiSight Technologies (R, F), Eyenuk, Inc. (F), Eyepress Fachmedien GmbH (R), glaucare GmbH (O, C), Heine Optotechnik GmbH (C, R, F), Heidelberg Engineering (R, F), Novartis Pharma GmbH (R, F), Optos (F), Pro Generika e.V. (R), Science Consulting in Diabetes GmbH (R). |
| References: | Am J Ophthalmol. 2005 Sep;140(3):509-16. (PMID: 16196117) Ophthalmology. 1985 Apr;92(4):467-71. (PMID: 4000641) Indian J Ophthalmol. 2020 Sep;68(9):1852-1862. (PMID: 32823402) J Ophthalmic Vis Res. 2015 Oct-Dec;10(4):469-80. (PMID: 27051493) J Chiropr Med. 2016 Jun;15(2):155-63. (PMID: 27330520) Semin Ophthalmol. 2005 Jul-Sep;20(3):147-54. (PMID: 16282148) Psychol Bull. 1979 Mar;86(2):420-8. (PMID: 18839484) Transl Vis Sci Technol. 2021 Dec 1;10(14):33. (PMID: 34967835) Middle East Afr J Ophthalmol. 2009 Oct;16(4):168-87. (PMID: 20404985) BMC Ophthalmol. 2014 Aug 30;14:103. (PMID: 25176513) Arch Ophthalmol. 1996 May;114(5):593-9. (PMID: 8619771) Am J Ophthalmol. 2010 Nov;150(5):637-641.e1. (PMID: 20719302) J Ophthalmol. 2014;2014:459136. (PMID: 25024846) BMC Ophthalmol. 2022 Jan 3;22(1):3. (PMID: 34980024) Int J Retina Vitreous. 2019 Jul 09;5:14. (PMID: 31333879) Int Ophthalmol Clin. 2012 Fall;52(4):33-43. (PMID: 22954927) Ocul Immunol Inflamm. 2017 Apr;25(2):202-209. (PMID: 26713716) Am J Ophthalmol. 2020 Jun;214:40-51. (PMID: 32112771) Ophthalmologica. 2021;244(5):465-479. (PMID: 34062542) Retina. 2012 Jul;32(7):1229-36. (PMID: 22466466) Sci Rep. 2024 Feb 5;14(1):2933. (PMID: 38317017) Am J Ophthalmol. 2018 Oct;194:35-45. (PMID: 30026083) |
| Contributed Indexing: | Keywords: Intermediate uveitis; Longitudinal; OCT; Optical coherence tomography |
| Entry Date(s): | Date Created: 20260617 Date Completed: 20260617 Latest Revision: 20260813 |
| Update Code: | 20260813 |
| PubMed Central ID: | PMC13276247 |
| DOI: | 10.1038/s41598-026-58318-z |
| PMID: | 42310384 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2045-2322 |
|---|---|
| DOI: | 10.1038/s41598-026-58318-z |