Academic Journal
Plant-based neuroprotection against memory impairment: Insights from Drosophila melanogaster models of neurodegenerative diseases.
| Τίτλος: | Plant-based neuroprotection against memory impairment: Insights from Drosophila melanogaster models of neurodegenerative diseases. |
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| Συγγραφείς: | Cynthia Irene Kasi; Department of Biotechnology, Vel Tech Rangarajan & Dr. Sagunthala R&D Institute of Science and Technology, Avadi, Chennai 600062, India., Azhagu Saravana Babu Packirisamy; Department of Biotechnology, Vel Tech Rangarajan & Dr. Sagunthala R&D Institute of Science and Technology, Avadi, Chennai 600062, India., Meivelu Moovendhan; Natural Products Research Laboratory, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai 602105, Tamil Nadu, India. Electronic address: moovendhan85@gmail.com. |
| Πηγή: | Neuroscience [Neuroscience] 2026 Aug 28; Vol. 610, pp. 255-272. Date of Electronic Publication: 2026 Jun 17. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605074 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7544 (Electronic) Linking ISSN: 03064522 NLM ISO Abbreviation: Neuroscience Subsets: MEDLINE |
| Imprint Name(s): | Publication: [New York?] : Elsevier Science Original Publication: Oxford, Elmsford, N. Y., Pergamon Press |
| Ιατρικοί όροι (MeSH): | Neurodegenerative Diseases*/drug therapy , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/therapeutic use , Memory Disorders*/drug therapy , Neuroprotection*/drug effects , Phytochemicals*/therapeutic use , Phytochemicals*/pharmacology, Animals ; Drosophila melanogaster ; Disease Models, Animal ; Humans |
| Περίληψη: | Neurodegenerative diseases are characterised by the progressive dysfunction of neurons, and memory impairment is one of their most debilitating clinical manifestations. The etiopathogenic mechanisms are multifactorial, such as protein misfolding, oxidative stress, and mitochondrial malfunction and synaptic degeneration along with neuroinflammation. As yet, therapists still focus mainly on symptomatic treatment and no agents are found to halt or reverse the decline of cognitive, indicating what is more needed is other kinds of neuroprotective strategy. In this context, the plant-derived phytochemicals stand out as promising candidates owing to their multi-targeted mode of action, favourable safety profile and long-standing use in traditional medicine systems. These bioactive compounds modulate oxidative stress, inflammatory signalling, neurotransmitter balance, apoptotic pathways and protein aggregation to elicit neuroprotection. The attention of the research community has also turned towards using Drosophila melanogaster as a model system for neurodegenerative-related studies due to its genetic tractability, accessible behavioural learning and memory tests, and the evolutionary conservation of potentially important biological pathways. This review consolidates recent evidence regarding plant-based neuroprotective strategies against memory impairment, with a specific focus on mechanistic mechanisms elucidated from Drosophila models of neurodegenerative diseases. Integrating findings across molecular, cellular and behavioural levels, the review illustrates the therapeutic promise of phytochemicals and reaffirms Drosophila as a valuable preclinical tool. It also addresses practical translational considerations, such as bioavailability, standardisation, and clinical validation, and sets forth future directions for effectiveness of plant-based interventions to facilitate improvements out in the real world. (Copyright © 2026 International Brain Research Organization (IBRO). Published by Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Drosophila melanogaster; Memory impairment; Neurodegenerative diseases; Neuroprotective mechanisms; Oxidative stress |
| Substance Nomenclature: | 0 (Neuroprotective Agents) 0 (Phytochemicals) |
| Entry Date(s): | Date Created: 20260617 Date Completed: 20260716 Latest Revision: 20260716 |
| Update Code: | 20260717 |
| DOI: | 10.1016/j.neuroscience.2026.06.012 |
| PMID: | 42309440 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1873-7544 |
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| DOI: | 10.1016/j.neuroscience.2026.06.012 |