Academic Journal
Audiogram Configuration Predicts Treatment Response in Sudden Sensorineural Hearing Loss.
| Τίτλος: | Audiogram Configuration Predicts Treatment Response in Sudden Sensorineural Hearing Loss. |
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| Συγγραφείς: | Guo L; Department of Otorhinolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.; Shaanxi Provincial Key Laboratory for Precision Diagnosis and Treatment of Otorhinolaryngology, Xi'an, China., Wang J; Department of Otorhinolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.; Shaanxi Provincial Key Laboratory for Precision Diagnosis and Treatment of Otorhinolaryngology, Xi'an, China., Gao Y; Department of Otorhinolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.; Shaanxi Provincial Key Laboratory for Precision Diagnosis and Treatment of Otorhinolaryngology, Xi'an, China., Wu B; Department of Otorhinolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.; Shaanxi Provincial Key Laboratory for Precision Diagnosis and Treatment of Otorhinolaryngology, Xi'an, China., Ren X; Department of Otorhinolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.; Shaanxi Provincial Key Laboratory for Precision Diagnosis and Treatment of Otorhinolaryngology, Xi'an, China., Li Y; Department of Otorhinolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.; Shaanxi Provincial Key Laboratory for Precision Diagnosis and Treatment of Otorhinolaryngology, Xi'an, China. |
| Πηγή: | Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery [Otolaryngol Head Neck Surg] 2026 Sep; Vol. 175 (3), pp. 612-617. Date of Electronic Publication: 2026 Jun 17. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Wiley Country of Publication: England NLM ID: 8508176 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6817 (Electronic) Linking ISSN: 01945998 NLM ISO Abbreviation: Otolaryngol Head Neck Surg Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2023- : [Oxford] : Wiley Original Publication: [Rochester, Minn.] : The Academy, [c1981- |
| Ιατρικοί όροι (MeSH): | Hearing Loss, Sensorineural*/diagnosis , Hearing Loss, Sensorineural*/therapy , Hearing Loss, Sensorineural*/physiopathology , Hearing Loss, Sudden*/therapy , Hearing Loss, Sudden*/diagnosis , Hearing Loss, Sudden*/physiopathology , Audiometry, Pure-Tone*, Humans ; Retrospective Studies ; Female ; Prognosis ; Male ; Middle Aged ; Adult ; Predictive Value of Tests ; Treatment Outcome ; Recovery of Function |
| Περίληψη: | Objective: To test whether the configuration of the initial pure tone audiogram (ascending, descending, flat or total-deaf) predicts complete recovery and to explore its value as a building block for prognostic models. Study Design: Retrospective cohort study. Setting: Single tertiary care centre. Methods: Adults with unilateral ISSNHL treated from January 2012 to December 2019 were categorised by audiogram configuration. Baseline characteristics and treatments were recorded. Multivariable logistic regression identified independent predictors of complete recovery; model performance was summarised by AUC and Nagelkerke R2. Results: Among 487 patients (43.8% flat, 29.4% descending, 21.9% total-deaf, 4.9% ascending), 80 (16.4%) achieved complete recovery. Complete recovery occurred in 50.0% of ascending, 25.2% flat, 9.8% descending and 0% total-deaf. Descending (OR 0.25; 95% CI 0.15-0.42) and total-deaf (OR 0.05; 95% CI 0.01-0.22) configurations independently predicted worse outcomes. Age and higher initial PTA were also negative predictors. AUC = 0.78; Nagelkerke R2 = 0.32. Conclusion: The initial audiogram configuration is an independent prognostic marker in ISSNHL. Ascending and flat patterns confer better prognosis than descending and total-deaf patterns; such classifications should be integrated into clinical risk stratification and future predictive models. (© 2026 American Academy of Otolaryngology–Head and Neck Surgery Foundation.) |
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| Grant Information: | 2024JC-YBMS-633 Natural Science Foundation of Shaanxi Province |
| Contributed Indexing: | Keywords: audiogram configuration; hearing recovery; prognosis; sudden sensorineural hearing loss; treatment response |
| Entry Date(s): | Date Created: 20260617 Date Completed: 20260829 Latest Revision: 20260831 |
| Update Code: | 20260831 |
| PubMed Central ID: | PMC13525883 |
| DOI: | 10.1002/ohn.70314 |
| PMID: | 42307984 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1097-6817 |
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| DOI: | 10.1002/ohn.70314 |