Academic Journal
Sustained mucosal delivery of SAMT-247 via an intravaginal ring reduces the risk of SIVmac251 acquisition in vaccinated macaques.
| Τίτλος: | Sustained mucosal delivery of SAMT-247 via an intravaginal ring reduces the risk of SIV |
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| Συγγραφείς: | Rahman MA; Animal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: mohammadarif.rahman@nih.gov., Woode EK; Animal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Moss JA; Oak Crest Institute of Science, Monrovia, CA, USA., Bissa M; Animal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Gunawardana M; Oak Crest Institute of Science, Monrovia, CA, USA., Gutowska A; Animal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Schifanella L; Animal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Silva de Castro I; Animal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Brown S; Animal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Stamos JD; Animal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Sarkis S; Animal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Robello M; Synthetic Bioactive Molecules Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA., Castonguay AE; Oak Crest Institute of Science, Monrovia, CA, USA., Butkyavichene I; Oak Crest Institute of Science, Monrovia, CA, USA., Pise-Masison CA; Animal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Choo-Wosoba H; Office of Collaborative Biostatistics, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA., Doster M; Animal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Alilin AN; Laboratory Animal Medicine, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Bethesda, MD, USA., Killoran KE; Laboratory Animal Medicine, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Bethesda, MD, USA., Kramer J; Laboratory Animal Medicine, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Bethesda, MD, USA., Breed MW; Laboratory Animal Medicine, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Bethesda, MD, USA; Clemson University, Clemson, SC, USA., Cardozo T; New York University Grossman School of Medicine, NYU Langone Health, New York, NY, USA., Appella DH; Synthetic Bioactive Molecules Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA., Baum MM; Oak Crest Institute of Science, Monrovia, CA, USA., Franchini G; Animal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: franchig@mail.nih.gov. |
| Πηγή: | Cell reports. Medicine [Cell Rep Med] 2026 Jul 21; Vol. 7 (7), pp. 102877. Date of Electronic Publication: 2026 Jun 16. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [Cambridge, MA] : Cell Press, [2020]- |
| Ιατρικοί όροι (MeSH): | Simian Immunodeficiency Virus*/immunology , Simian Immunodeficiency Virus*/drug effects , Simian Acquired Immunodeficiency Syndrome*/prevention & control , Simian Acquired Immunodeficiency Syndrome*/immunology , Simian Acquired Immunodeficiency Syndrome*/virology , Benzamides*/administration & dosage , Benzamides*/pharmacology , Sulfhydryl Compounds*/administration & dosage , Sulfhydryl Compounds*/pharmacology , SAIDS Vaccines*/immunology, Immunity, Mucosal/drug effects ; Vagina/virology ; Vagina/immunology ; Killer Cells, Natural/immunology ; Killer Cells, Natural/drug effects ; Mucous Membrane/drug effects ; Mucous Membrane/immunology ; Animals ; Female ; Administration, Intravaginal ; Macaca mulatta ; Vaccination |
| Περίληψη: | We assess the combined effect of sustained mucosal delivery of the anti-HIV small molecule S-acyl-2-mercaptobenzamide thioester 247 (SAMT-247) via an intravaginal ring (IVR) and ΔV1DNA/ALVAC-SIV/ΔV1gp120/alum (ΔV1-SIV) immunization in female macaques. The combined approach reduces the risk of vaginal SIV (Published by Elsevier Inc.) |
| Competing Interests: | Declaration of interests The US Government and NYU hold the patent “HIV-1 vaccination and SAMT-247 microbicide to prevent HIV-1 infection.” Application number: 18/681,019; publication number: US2024/0277829 A1; and publication date: 08/22/2024. |
| Contributed Indexing: | Keywords: HIV/SIV vaccine; SAMT-247; SIVmac251; V2-specific ADCC; dendritic cells; immunomodulation; infiltrating monocytes; innate lymphoid cells; mucosal immunity; vaccine-induced immunity |
| Substance Nomenclature: | 0 (Benzamides) 0 (Sulfhydryl Compounds) 0 (SAIDS Vaccines) |
| Entry Date(s): | Date Created: 20260616 Date Completed: 20260721 Latest Revision: 20260727 |
| Update Code: | 20260727 |
| PubMed Central ID: | PMC13400162 |
| DOI: | 10.1016/j.xcrm.2026.102877 |
| PMID: | 42302793 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2666-3791 |
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| DOI: | 10.1016/j.xcrm.2026.102877 |