Academic Journal
Bioorthogonal tuning of nanosurface opsonisation via click coupling of a complement fusion protein inhibitor.
| Title: | Bioorthogonal tuning of nanosurface opsonisation via click coupling of a complement fusion protein inhibitor. |
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| Authors: | Jacques S; Department of Pharmaceutical Sciences, The Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. seyed.moghimi@newcastle.ac.uk., Gaikwad H; Department of Pharmaceutical Sciences, The Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. seyed.moghimi@newcastle.ac.uk., Pillatzke J; School of Pharmacy and Pharmaceutical Sciences, Panoz Institute, Trinity College Dublin, Dublin 2, Ireland., Moghimi SM; Department of Pharmaceutical Sciences, The Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. seyed.moghimi@newcastle.ac.uk.; School of Pharmacy, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.; Translational and Clinical Research Institute, Faculty of Health and Medical Sciences, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Simberg D; Department of Pharmaceutical Sciences, The Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. seyed.moghimi@newcastle.ac.uk. |
| Source: | Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2026 Jul 03; Vol. 62 (51), pp. 12859-12862. Date of Electronic Publication: 2026 Jul 03. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 9610838 Publication Model: Electronic Cited Medium: Internet ISSN: 1364-548X (Electronic) Linking ISSN: 13597345 NLM ISO Abbreviation: Chem Commun (Camb) Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Cambridge : Royal Society of Chemistry |
| MeSH Terms: | Recombinant Fusion Proteins*/chemistry , Receptors, Complement 3d*/chemistry , Nanoparticles*/chemistry , Complement System Proteins*/chemistry, Polyethylene Glycols/chemistry ; Complement Activation/drug effects ; Click Chemistry ; Humans |
| Abstract: | Complement opsonisation contributes to immune clearance of nanopharmaceuticals, but complement activation has some undesirable effects. Herein, we show that tethering the fusion complement receptor 2-complement receptor 1 (CR2-CR1) regulator to cross-linked iron oxide nanoworms via a PEG spacer and copper-free click chemistry overcomes complement opsonisation. Furthermore, CR2-CR1-conjugated nanoworms reduce complement opsonisation of unmodified nanoparticles. |
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| Grant Information: | R01 AI154959 United States AI NIAID NIH HHS |
| Substance Nomenclature: | 3WJQ0SDW1A (Polyethylene Glycols) 0 (Recombinant Fusion Proteins) 0 (Receptors, Complement 3d) 9007-36-7 (Complement System Proteins) |
| Entry Date(s): | Date Created: 20260616 Date Completed: 20260703 Latest Revision: 20260830 |
| Update Code: | 20260830 |
| PubMed Central ID: | PMC13262778 |
| DOI: | 10.1039/d6cc00733c |
| PMID: | 42300746 |
| Database: | MEDLINE |
| ISSN: | 1364-548X |
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| DOI: | 10.1039/d6cc00733c |