Academic Journal
Προβολή σε EDS

Use of Mendelian Randomization to Unveil Metabolic Markers in Helicobacter pylori Infection.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Use of Mendelian Randomization to Unveil Metabolic Markers in Helicobacter pylori Infection.
Συγγραφείς: Hoang T; Department of Cancer AI & Digital Health, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Korea.; Faculty of Pharmacy, University of Health Sciences, Vietnam National University Ho Chi Minh City, Ho Chi Minh City, Vietnam., Kim J; Department of Cancer AI & Digital Health, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Korea. jskim@ncc.re.kr.
Πηγή: Journal of Korean medical science [J Korean Med Sci] 2026 Jun 15; Vol. 41 (23), pp. e13. Date of Electronic Publication: 2026 Jun 15.
Τύπος έκδοσης: Journal Article; Meta-Analysis
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Korean Academy of Medical Science Country of Publication: Korea (South) NLM ID: 8703518 Publication Model: Electronic Cited Medium: Internet ISSN: 1598-6357 (Electronic) Linking ISSN: 10118934 NLM ISO Abbreviation: J Korean Med Sci Subsets: MEDLINE
Imprint Name(s): Original Publication: Seoul, Korea : Korean Academy of Medical Science, [1986-
Ιατρικοί όροι (MeSH): Helicobacter Infections*/metabolism , Helicobacter Infections*/microbiology , Helicobacter Infections*/genetics , Helicobacter Infections*/pathology , Helicobacter Infections*/diagnosis , Helicobacter pylori*/immunology, Antibodies, Bacterial/blood ; Antibodies, Bacterial/immunology ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Bacterial Proteins/immunology ; Biomarkers/metabolism ; Urease/genetics ; Urease/metabolism ; Antigens, Bacterial/genetics ; Antigens, Bacterial/immunology ; Humans ; Mendelian Randomization Analysis ; Genome-Wide Association Study ; Polymorphism, Single Nucleotide ; Genetic Predisposition to Disease
Περίληψη: Background: Enzymes encoded by Helicobacter pylori are involved in various metabolic processes. Using a Mendelian randomization (MR) framework, we investigated the metabolites associated with six antibodies against H. pylori and explored the potential underlying biological pathways.
Methods: A meta-analysis of 65 genome-wide association studies was conducted to assess the genetic predisposition to approximately 3,550 metabolites. Summary-level data for > 10 million genetic variants associated with H. pylori antibodies were extracted from the UK Biobank. MR analysis was performed using inverse-variance weighting, weighted median, and Egger regression to ensure robust findings. Significant metabolites were further analyzed using enrichment analysis to identify the relevant biological pathways.
Results: A total of 100 metabolites were positively associated with H. pylori antibodies (cytotoxin-associated gene A [CagA], 16; catalase, 25; GroEL, 16; outer membrane protein [OMP], 22; urease [UREA], 15; and vacuolating cytotoxin [VacA], 6). These metabolites were linked to pathways involving the metabolism of alanine, aspartate, glutamate, glycine, serine, threonine, purine, and tryptophan in four antibodies. Additionally, 67 metabolites were negatively associated with H. pylori antibodies (CagA, 11; catalase, 6; GroEL, 13; OMP, 11; UREA, 11; and VacA, 15). These metabolites were primarily involved in pyrimidine metabolism in the three antibodies.
Conclusion: Our study identified numerous metabolites linked to H. pylori antibody levels, indicating that metabolic alterations are associated with infection. These changes were particularly enriched in pathways involved in amino acid, nucleotide, and coenzyme metabolism and biosynthesis. These findings highlight the systemic metabolic impact of H. pylori infection and offer insights into the biological mechanisms underlying host-pathogen interactions.
(© 2026 The Korean Academy of Medical Sciences.)
Competing Interests: The authors have no potential conflicts of interest to disclose.
References: Nat Genet. 2010 Feb;42(2):137-41. (PMID: 20037589)
Hum Mol Genet. 2020 Mar 27;29(5):864-875. (PMID: 31960908)
Nat Genet. 2021 Jan;53(1):54-64. (PMID: 33414548)
Hum Mol Genet. 2012 Mar 15;21(6):1444-55. (PMID: 22156771)
Trends Biochem Sci. 2014 Apr;39(4):191-8. (PMID: 24657017)
PLoS Med. 2016 Nov 29;13(11):e1002179. (PMID: 27898682)
PLoS Genet. 2015 Sep 24;11(9):e1005510. (PMID: 26401656)
Stat Med. 2017 May 20;36(11):1783-1802. (PMID: 28114746)
Commun Biol. 2022 Apr 7;5(1):334. (PMID: 35393526)
Cancer Biol Med. 2022 Aug 30;19(8):. (PMID: 36069529)
Hum Mol Genet. 2016 Dec 15;25(24):5472-5482. (PMID: 27702941)
Nature. 2011 Aug 31;477(7362):54-60. (PMID: 21886157)
Hum Mol Genet. 2018 May 1;27(9):1664-1674. (PMID: 29481666)
Nat Genet. 2020 Feb;52(2):167-176. (PMID: 31959995)
Int J Oncol. 2021 Feb;58(2):158-170. (PMID: 33491748)
Genet Epidemiol. 2016 May;40(4):304-14. (PMID: 27061298)
Nat Commun. 2018 Jan 23;9(1):333. (PMID: 29362361)
PLoS Genet. 2015 Sep 09;11(9):e1005487. (PMID: 26352407)
Hum Mol Genet. 2022 Sep 29;31(19):3367-3376. (PMID: 34718574)
Nat Genet. 2017 Apr;49(4):568-578. (PMID: 28263315)
Hum Mol Genet. 2016 Mar 15;25(6):1215-24. (PMID: 26744325)
Nat Genet. 2014 Jun;46(6):543-550. (PMID: 24816252)
Lancet Child Adolesc Health. 2022 Mar;6(3):185-194. (PMID: 35085494)
Circ Cardiovasc Genet. 2015 Apr;8(2):351-5. (PMID: 25575548)
PLoS One. 2018 May 8;13(5):e0196951. (PMID: 29738550)
Helicobacter. 2018 Apr;23(2):e12463. (PMID: 29345022)
Nat Genet. 2011 Jun;43(6):565-9. (PMID: 21572414)
Ann Clin Epidemiol. 2025 Jan 1;7(1):27-37. (PMID: 39926273)
Am J Clin Nutr. 2015 Feb;101(2):398-406. (PMID: 25646338)
Biomark Res. 2023 May 5;11(1):48. (PMID: 37147729)
Cell Mol Immunol. 2020 Jan;17(1):50-63. (PMID: 31804619)
BMC Med. 2021 Sep 10;19(1):232. (PMID: 34503513)
Nat Commun. 2023 Aug 21;14(1):5062. (PMID: 37604891)
Cancer Res Treat. 2021 Jul;53(3):744-753. (PMID: 33321562)
Chin Med J (Engl). 2024 Aug 20;137(16):1926-1938. (PMID: 38230488)
Digestion. 2023;104(2):97-108. (PMID: 36404717)
Nucleic Acids Res. 2024 Jul 5;52(W1):W398-W406. (PMID: 38587201)
PLoS Genet. 2009 Oct;5(10):e1000672. (PMID: 19798445)
Front Cell Infect Microbiol. 2024 Feb 26;14:1342913. (PMID: 38469348)
Front Cell Infect Microbiol. 2023 Apr 14;13:1062803. (PMID: 37124036)
Am J Hum Genet. 2020 Nov 5;107(5):849-863. (PMID: 33031748)
Braz J Med Biol Res. 2012 Jan;45(1):78-85. (PMID: 22124703)
Front Cell Infect Microbiol. 2016 Nov 22;6:159. (PMID: 27921009)
Mol Carcinog. 2025 Mar;64(3):463-474. (PMID: 39630052)
Genome Med. 2013 Feb 15;5(2):13. (PMID: 23414815)
Sci Adv. 2024 Aug 2;10(31):eadi8646. (PMID: 39083605)
PLoS Genet. 2012;8(10):e1003005. (PMID: 23093944)
PLoS Genet. 2009 Jan;5(1):e1000338. (PMID: 19148276)
World J Clin Cases. 2024 Feb 16;12(5):951-965. (PMID: 38414611)
J Lipid Res. 2015 Jan;56(1):176-84. (PMID: 25378659)
PLoS One. 2016 Apr 13;11(4):e0153672. (PMID: 27073872)
Hum Mutat. 2013 Mar;34(3):515-24. (PMID: 23281178)
PLoS Genet. 2011 Jul;7(7):e1002193. (PMID: 21829377)
Hum Mol Genet. 2017 Sep 1;26(17):3442-3450. (PMID: 28854705)
Int J Epidemiol. 2015 Apr;44(2):512-25. (PMID: 26050253)
Gastroenterology. 2024 Apr;166(4):605-619. (PMID: 38176660)
Expert Rev Mol Diagn. 2023 Jul-Dec;23(12):1251-1261. (PMID: 37905778)
FEBS J. 2023 Jan;290(1):7-27. (PMID: 34687129)
PLoS Genet. 2017 Oct 30;13(10):e1007079. (PMID: 29084231)
Nat Commun. 2021 Feb 11;12(1):964. (PMID: 33574263)
Prostaglandins Leukot Essent Fatty Acids. 2015 Mar;94:65-72. (PMID: 25500335)
Genome Biol. 2016 Nov 24;17(1):237. (PMID: 27884205)
Genet Epidemiol. 2013 Dec;37(8):840-5. (PMID: 23934736)
Nat Commun. 2016 Jul 25;7:12360. (PMID: 27453504)
PLoS Genet. 2008 Nov;4(11):e1000282. (PMID: 19043545)
PLoS Genet. 2014 Feb 20;10(2):e1004132. (PMID: 24586186)
JAMA. 2017 Nov 21;318(19):1925-1926. (PMID: 29164242)
J Lipid Res. 2017 May;58(5):974-981. (PMID: 28298293)
Biomed J. 2016 Feb;39(1):14-23. (PMID: 27105595)
Kidney Int. 2021 Aug;100(2):430-439. (PMID: 33838163)
Gastroenterology. 2022 May;162(6):1591-1593. (PMID: 35278417)
Nat Commun. 2015 Jun 12;6:7208. (PMID: 26068415)
Diabetes. 2013 Jun;62(6):2141-50. (PMID: 23378610)
Pathogens. 2024 May 08;13(5):. (PMID: 38787244)
Circ Cardiovasc Genet. 2014 Jun;7(3):321-331. (PMID: 24823311)
Circ Cardiovasc Genet. 2013 Apr;6(2):171-83. (PMID: 23362303)
Nat Genet. 2012 Jan 29;44(3):269-76. (PMID: 22286219)
World J Clin Cases. 2022 Jul 6;10(19):6349-6359. (PMID: 35979311)
PLoS Genet. 2012;8(8):e1002907. (PMID: 22916037)
Korean J Intern Med. 2021 Jul;36(4):807-838. (PMID: 34092054)
PLoS Genet. 2015 Nov 05;11(11):e1005553. (PMID: 26540294)
Helicobacter. 2024 Jan-Feb;29(1):e13058. (PMID: 38380545)
Commun Biol. 2021 Jan 12;4(1):63. (PMID: 33437055)
PLoS Genet. 2011 Sep;7(9):e1002270. (PMID: 21931564)
Clin Transl Med. 2021 Feb;11(2):e290. (PMID: 33634981)
Cell Death Dis. 2021 Nov 24;12(12):1104. (PMID: 34819503)
J Gastric Cancer. 2022 Jul;22(3):169-183. (PMID: 35938364)
PLoS Genet. 2012;8(2):e1002490. (PMID: 22359512)
Genetics. 2018 Jun;209(2):607-616. (PMID: 29610217)
Genet Epidemiol. 2016 Sep;40(6):486-91. (PMID: 27256581)
Cell Metab. 2013 Jul 2;18(1):130-43. (PMID: 23823483)
Biomed Chromatogr. 2023 Jun;37(6):e5622. (PMID: 36898359)
PLoS Genet. 2015 Jan 08;11(1):e1004835. (PMID: 25569235)
PLoS Genet. 2014 Mar 13;10(3):e1004212. (PMID: 24625756)
Open Forum Infect Dis. 2020 Sep 24;7(11):ofaa450. (PMID: 33204752)
Nat Commun. 2016 Mar 23;7:11122. (PMID: 27005778)
Nat Commun. 2016 Jan 29;7:10558. (PMID: 26822151)
PLoS One. 2018 Apr 13;13(4):e0194882. (PMID: 29652918)
Diabetologia. 2016 Oct;59(10):2114-24. (PMID: 27406814)
Grant Information: 2021R1A2C2008439 Korea NRF National Research Foundation of Korea; 2510880 Republic of Korea National Cancer Center
Contributed Indexing: Keywords: Antibody; Helicobacter pylori; Mendelian Randomization
Substance Nomenclature: 0 (Antibodies, Bacterial)
0 (Bacterial Proteins)
0 (Biomarkers)
EC 3.5.1.5 (Urease)
0 (Antigens, Bacterial)
0 (cagA protein, Helicobacter pylori)
Entry Date(s): Date Created: 20260616 Date Completed: 20260616 Latest Revision: 20260813
Update Code: 20260813
PubMed Central ID: PMC13269816
DOI: 10.3346/jkms.2026.41.e13
PMID: 42299135
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1598-6357
DOI:10.3346/jkms.2026.41.e13