Academic Journal
Dentin tubule penetration of a calcium silicate-based sealer after removal of calcium hydroxide or N-acetylcysteine medicaments: an in vitro study.
| Τίτλος: | Dentin tubule penetration of a calcium silicate-based sealer after removal of calcium hydroxide or N-acetylcysteine medicaments: an in vitro study. |
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| Συγγραφείς: | Coşar S; Department of Endodontics, Faculty of Dentistry, Hatay Mustafa Kemal University, Hatay, Turkey., Sarı M; Department of Endodontics, Faculty of Dentistry, Hatay Mustafa Kemal University, Hatay, Turkey. sarimerve94@outlook.com. |
| Πηγή: | BMC oral health [BMC Oral Health] 2026 Jun 15; Vol. 26 (1). Date of Electronic Publication: 2026 Jun 15. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: BioMed Central Country of Publication: England NLM ID: 101088684 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-6831 (Electronic) Linking ISSN: 14726831 NLM ISO Abbreviation: BMC Oral Health Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : BioMed Central, [2001- |
| Ιατρικοί όροι (MeSH): | Silicates*/chemistry , Calcium Hydroxide*/chemistry , Calcium Compounds*/chemistry , Root Canal Filling Materials*/chemistry , Acetylcysteine*/chemistry , Root Canal Irrigants*/chemistry , Dentin*/ultrastructure , Dentin Permeability*, Root Canal Preparation/methods ; Root Canal Obturation/methods ; Humans ; Microscopy, Confocal ; Materials Testing ; Drug Combinations ; Bicuspid |
| Περίληψη: | Background: This study aimed to evaluate, using confocal laser scanning microscopy (CLSM), the dentin tubule penetration of a calcium silicate-based root canal sealer after removal of calcium hydroxide (Ca(OH) Methods: Root canals of 128 extracted single-rooted mandibular premolars were prepared with ProTaper Next. Canals received Ca(OH) Results: Neither the type of intracanal medicament nor the activation technique significantly affected the residual medicament amount (p > 0.05). However, the type of medicament significantly influenced sealer penetration, with NAC showing greater dentin tubule penetration than Ca(OH)₂ (p < 0.05). The activation technique did not significantly influence sealer penetration (p > 0.05). Sealer penetration was highest in the coronal third and lowest in the apical third (p < 0.05). Conclusion: Within the limitations of this in vitro study, NAC enhanced the dentin tubule penetration of a calcium silicate-based sealer compared with Ca(OH)₂. The activation technique did not affect sealer penetration or residual medicament. (© 2026. The Author(s).) |
| Competing Interests: | Declarations. Ethics approval and consent to participate: This study was approved by the Hatay Mustafa Kemal University, Non Interventional Research Ethics Committee (Protocol Number: 2024/22). The authors certify that the study was performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. Written informed consent to participate was obtained from the all individual participants included in the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. |
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| Grant Information: | 24.DHU.002 Hatay Mustafa Kemal University Scientific Research Projects |
| Contributed Indexing: | Keywords: Calcium hydroxide; Calcium silicate–based sealer; Confocal laser scanning microscopy; N-acetylcysteine |
| Substance Nomenclature: | 0 (Silicates) PF5DZW74VN (Calcium Hydroxide) 0 (Calcium Compounds) S4255P4G5M (calcium silicate) 0 (Root Canal Filling Materials) WYQ7N0BPYC (Acetylcysteine) 0 (Root Canal Irrigants) 0 (Drug Combinations) |
| Entry Date(s): | Date Created: 20260616 Date Completed: 20260828 Latest Revision: 20260910 |
| Update Code: | 20260911 |
| PubMed Central ID: | PMC13523325 |
| DOI: | 10.1186/s12903-026-08809-2 |
| PMID: | 42298535 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1472-6831 |
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| DOI: | 10.1186/s12903-026-08809-2 |