Academic Journal
Pectic polysaccharide from Phytolacca acinosa Roxb. alleviates non-alcoholic fatty liver disease via the gut microbiota-short-chain fatty acids-liver axis.
| Τίτλος: | Pectic polysaccharide from Phytolacca acinosa Roxb. alleviates non-alcoholic fatty liver disease via the gut microbiota-short-chain fatty acids-liver axis. |
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| Συγγραφείς: | Wang Q; College of Agronomy, Henan Agricultural University, Zhengzhou, Henan, PR China; Henan University of Animal Husbandry and Economy, Zhengzhou, Henan, PR China., Jia H; College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan, PR China., Yang L; College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan, PR China., Xie T; College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan, PR China., Zhang Z; College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan, PR China. Electronic address: zhiqiangzhang2022@163.com., Zhang F; Henan University of Animal Husbandry and Economy, Zhengzhou, Henan, PR China. Electronic address: fjzhang1995@163.com., Xie Y; College of Agronomy, Henan Agricultural University, Zhengzhou, Henan, PR China. Electronic address: xieyingxin@henau.edu.cn. |
| Πηγή: | International journal of biological macromolecules [Int J Biol Macromol] 2026 Aug; Vol. 373, pp. 153053. Date of Electronic Publication: 2026 Jun 15. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE |
| Imprint Name(s): | Publication: Amsterdam : Elsevier Original Publication: Guildford, Eng., IPC Science and Technology Press. |
| Ιατρικοί όροι (MeSH): | Non-alcoholic Fatty Liver Disease*/drug therapy , Non-alcoholic Fatty Liver Disease*/metabolism , Non-alcoholic Fatty Liver Disease*/pathology , Non-alcoholic Fatty Liver Disease*/microbiology , Liver*/drug effects , Liver*/metabolism , Liver*/pathology , Fatty Acids, Volatile*/metabolism , Gastrointestinal Microbiome*/drug effects , Phytolacca*/chemistry , Pectins*/chemistry , Pectins*/pharmacology , Polysaccharides*/pharmacology , Polysaccharides*/chemistry, Lipid Metabolism/drug effects ; Animals ; Mice ; Male |
| Περίληψη: | This study investigates the therapeutic potential and underlying mechanisms of Phytolacca acinosa Roxb. Polysaccharide (PRP-2-3), a pectic polysaccharide extracted from Phytolacca acinosa Roxb., is known for its cardioprotective, antidiabetic, antiviral, and antioxidant properties. Structural characterization revealed that PRP-2-3 is a homogeneous pectic polysaccharide, primarily composed of GalA (38.256%), Ara (9.764%), Rha (10.523%), and Gal (19.957%). It consists mainly of HG-type domains, with some RG-I domains. In NAFLD-induced mice, PRP-2-3 exerted dose-dependent hepatoprotective effects, including reduced hepatic lipid accumulation, attenuation of liver injury, and improvement of steatosis. Taken together, these findings indicate that PRP-2-3 alleviates hepatic injury associated with NAFLD through modulation of gut microbiota (GM), augmentation of short-chain fatty acid (SCFA) biosynthesis, and reinforcement of intestinal barrier function. (Copyright © 2026. Published by Elsevier B.V.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Gut microbiota; Intestinal barrier; Non-alcoholic fatty liver disease; Phytolacca acinosa Roxb. Polysaccharide; Short-chain fatty acids |
| Substance Nomenclature: | 0 (Fatty Acids, Volatile) 89NA02M4RX (Pectins) 0 (Polysaccharides) |
| Entry Date(s): | Date Created: 20260615 Date Completed: 20260730 Latest Revision: 20260730 |
| Update Code: | 20260730 |
| DOI: | 10.1016/j.ijbiomac.2026.153053 |
| PMID: | 42297168 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1879-0003 |
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| DOI: | 10.1016/j.ijbiomac.2026.153053 |