Academic Journal
Comparative efficacy and economic impact of sequential triple therapy versus nano-silver dressings in delayed-presentation low-temperature burns: A retrospective cohort study.
| Τίτλος: | Comparative efficacy and economic impact of sequential triple therapy versus nano-silver dressings in delayed-presentation low-temperature burns: A retrospective cohort study. |
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| Συγγραφείς: | Li S; Department of Burn and Plastic Surgery, The 969th Hospital of Joint Logistics Support Force, Hohhot, Inner Mongolia 010051, China., Sun X; Department of Burn and Plastic Surgery, The 969th Hospital of Joint Logistics Support Force, Hohhot, Inner Mongolia 010051, China., Sun W; Department of Burn and Plastic Surgery, The 969th Hospital of Joint Logistics Support Force, Hohhot, Inner Mongolia 010051, China., Han D; Department of Burn and Plastic Surgery, The 969th Hospital of Joint Logistics Support Force, Hohhot, Inner Mongolia 010051, China., Liu Y; Department of Burn and Plastic Surgery, The 969th Hospital of Joint Logistics Support Force, Hohhot, Inner Mongolia 010051, China., Liu X; Department of Burn and Plastic Surgery, The 969th Hospital of Joint Logistics Support Force, Hohhot, Inner Mongolia 010051, China., Sui F; Department of Burn and Plastic Surgery, The 969th Hospital of Joint Logistics Support Force, Hohhot, Inner Mongolia 010051, China. Electronic address: sfq698768@qq.com. |
| Πηγή: | Burns : journal of the International Society for Burn Injuries [Burns] 2026 Sep; Vol. 52 (7), pp. 108023. Date of Electronic Publication: 2026 Apr 18. |
| Τύπος έκδοσης: | Journal Article; Comparative Study |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8913178 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1409 (Electronic) Linking ISSN: 03054179 NLM ISO Abbreviation: Burns Subsets: MEDLINE |
| Imprint Name(s): | Publication: Amsterdam : Elsevier Original Publication: [Guildford, Surrey, UK] : Butterworths, [c1989- |
| Ιατρικοί όροι (MeSH): | Burns*/therapy , Burns*/drug therapy , Silver Sulfadiazine*/therapeutic use , Silver Sulfadiazine*/economics , Anti-Infective Agents, Local*/therapeutic use , Bandages*, Wound Healing/drug effects ; Wound Infection/epidemiology ; Silver/therapeutic use ; Humans ; Retrospective Studies ; Female ; Male ; Adult ; Middle Aged ; Treatment Outcome |
| Περίληψη: | Objective: To compare the comprehensive efficacy of a triple therapy combining silver sulfadiazine cream, recombinant human epidermal growth factor (rhEGF), and Compound Huangbai Liquid (Combined Group) versus a nano-silver dressing regimen (Traditional Group) for small-area (<1% TBSA), low-temperature burns that progressed to deep burns due to delayed presentation. Methods: A retrospective cohort study was conducted, enrolling 309 patients admitted between January 2023 and December 2024 who were diagnosed with deep second- to third-degree burns following delayed presentation after initial neglect of blisters. The Combined Group (n = 165) received the triple therapy, and the Traditional Group (n = 144) received the nano-silver dressing regimen. Wound healing time, frequency of dressing changes, VAS pain score, wound infection rate, and economic burden were evaluated. Results: The wound healing time in the Combined Group was significantly shorter than in the Traditional Group (28 ± 4 days vs. 41 ± 5 days, P < 0.001), with fewer dressing changes (14 ± 3 times vs. 21 ± 4 times, P < 0.001). The pain scores were significantly lower in the Combined Group from the second dressing change onward (P < 0.05). There was no statistical difference in wound infection rates between the two groups (2.4% vs. 3.5%, P > 0.05). Further precise accounting showed that both the total cost and out-of-pocket expenses for patients in the Combined Group were significantly lower than those in the Traditional Group (Total cost: 1508 ± 360 CNY vs. 3735 ± 480 CNY; Out-of-pocket: 302 ± 72 CNY vs. 1904 ± 96 CNY, P < 0.001). Conclusion: For small-area, low-temperature deep burns that have worsened due to delayed presentation, the combined regimen demonstrates significant superiority over the traditional regimen in accelerating healing, reducing pain, and, most notably, drastically lowering the economic burden on patients through synergistic drug actions. It represents an ideal choice for addressing this clinical challenge. (Copyright © 2026 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| Competing Interests: | Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper |
| Contributed Indexing: | Keywords: Combined therapy; Delayed presentation; Low-temperature burn; Pharmacoeconomics; Small-area deep burn |
| Substance Nomenclature: | W46JY43EJR (Silver Sulfadiazine) 0 (Anti-Infective Agents, Local) 3M4G523W1G (Silver) |
| Entry Date(s): | Date Created: 20260615 Date Completed: 20260703 Latest Revision: 20260703 |
| Update Code: | 20260704 |
| DOI: | 10.1016/j.burns.2026.108023 |
| PMID: | 42296882 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1879-1409 |
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| DOI: | 10.1016/j.burns.2026.108023 |