Academic Journal
Galectin-3 Regulates Smooth Muscle Contraction and Blood Pressure by Modulating CaV1.2 Channel Function.
| Τίτλος: | Galectin-3 Regulates Smooth Muscle Contraction and Blood Pressure by Modulating Ca |
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| Συγγραφείς: | Loh KWZ; Department of Physiology (K.W.Z.L., Y.Z., C.L., J.Z., D.Y., M.C.L., Z.H., T.W.S.), National University of Singapore.; Yong Loo Lin School of Medicine, Cardiovascular and Metabolic Diseases Translational Research Programme (K.W.Z.L., C.L., T.W.S.), National University of Singapore., Zhou Y; Department of Physiology (K.W.Z.L., Y.Z., C.L., J.Z., D.Y., M.C.L., Z.H., T.W.S.), National University of Singapore.; Institute for Functional Intelligent Materials (Y.Z., T.W.S.), National University of Singapore., Liu C; Department of Physiology (K.W.Z.L., Y.Z., C.L., J.Z., D.Y., M.C.L., Z.H., T.W.S.), National University of Singapore.; Yong Loo Lin School of Medicine, Cardiovascular and Metabolic Diseases Translational Research Programme (K.W.Z.L., C.L., T.W.S.), National University of Singapore., Zhai J; Department of Physiology (K.W.Z.L., Y.Z., C.L., J.Z., D.Y., M.C.L., Z.H., T.W.S.), National University of Singapore., Jaladanki CK; Bioinformatics Institute, Agency for Science, Technology, and Research, Singapore (C.K.J.)., Jia Yi Neo C; Department of Research, National Neuroscience Institute, Singapore (C.J.Y.N., M.S., P.L., Z.H., T.W.S.)., Yu D; Department of Physiology (K.W.Z.L., Y.Z., C.L., J.Z., D.Y., M.C.L., Z.H., T.W.S.), National University of Singapore.; Electrophysiology Core Facility (D.Y.), National University of Singapore., Liang MC; Department of Physiology (K.W.Z.L., Y.Z., C.L., J.Z., D.Y., M.C.L., Z.H., T.W.S.), National University of Singapore., Shen M; Department of Research, National Neuroscience Institute, Singapore (C.J.Y.N., M.S., P.L., Z.H., T.W.S.)., Fan H; Chinese Institute for Molecular and Cellular Therapeutics, Chinese Institutes for Medical Research, Beijing, China (H.F.)., Liao P; Department of Research, National Neuroscience Institute, Singapore (C.J.Y.N., M.S., P.L., Z.H., T.W.S.)., Hu Z; Department of Physiology (K.W.Z.L., Y.Z., C.L., J.Z., D.Y., M.C.L., Z.H., T.W.S.), National University of Singapore.; Department of Research, National Neuroscience Institute, Singapore (C.J.Y.N., M.S., P.L., Z.H., T.W.S.)., Soong TW; Department of Physiology (K.W.Z.L., Y.Z., C.L., J.Z., D.Y., M.C.L., Z.H., T.W.S.), National University of Singapore.; Yong Loo Lin School of Medicine, Cardiovascular and Metabolic Diseases Translational Research Programme (K.W.Z.L., C.L., T.W.S.), National University of Singapore.; Institute for Functional Intelligent Materials (Y.Z., T.W.S.), National University of Singapore.; Healthy Longevity Translational Research Programme (T.W.S.), National University of Singapore.; Department of Research, National Neuroscience Institute, Singapore (C.J.Y.N., M.S., P.L., Z.H., T.W.S.).; Integrative Sciences and Engineering Programme, NUS Graduate School, Singapore (T.W.S.). |
| Πηγή: | Circulation [Circulation] 2026 Sep; Vol. 154 (9), pp. 819-834. Date of Electronic Publication: 2026 Jun 15. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0147763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4539 (Electronic) Linking ISSN: 00097322 NLM ISO Abbreviation: Circulation Subsets: MEDLINE |
| Imprint Name(s): | Publication: Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: [Dallas, Tex., etc., American Heart Association, etc.] |
| Ιατρικοί όροι (MeSH): | Calcium Channels, L-Type*/metabolism , Calcium Channels, L-Type*/genetics , Galectin 3*/metabolism , Galectin 3*/genetics , Galectin 3*/deficiency , Blood Pressure*/physiology , Blood Pressure*/drug effects , Muscle, Smooth, Vascular*/metabolism , Muscle, Smooth, Vascular*/drug effects , Hypertension*/physiopathology , Hypertension*/metabolism , Hypertension*/drug therapy , Muscle Contraction*/physiology, Animals ; Humans ; Rats, Inbred SHR ; HEK293 Cells ; Mice ; Mice, Knockout ; Rats ; Male ; Mice, Inbred C57BL |
| Περίληψη: | Background: Fine-tuning of Ca Methods: In vitro, ex vivo, and in vivo experiments involving molecular and biochemical assays, in silico prediction, patch-clamp electrophysiologic recordings, immunohistochemistry, pressure myography, and tail-cuff BP measurements were used to evaluate the molecular mechanisms by which Gal-3 binds to and elevates membrane insertion of Ca Results: We identified Gal-3 as a novel binding partner and unexpected positive modulator of the Ca Conclusions: These results provide strong evidence that Gal-based Ca |
| Competing Interests: | None. |
| Contributed Indexing: | Keywords: calcium channels; galectin 3; hypertension; muscle contraction; peptides |
| Substance Nomenclature: | 0 (Calcium Channels, L-Type) 0 (Galectin 3) 0 (L-type calcium channel alpha(1C)) |
| Entry Date(s): | Date Created: 20260615 Date Completed: 20260831 Latest Revision: 20260831 |
| Update Code: | 20260901 |
| DOI: | 10.1161/CIRCULATIONAHA.126.080022 |
| PMID: | 42290338 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1524-4539 |
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| DOI: | 10.1161/CIRCULATIONAHA.126.080022 |