Academic Journal
Cellular senescence in ischemic stroke: Cell-type specificity, temporal dynamics, and response to therapeutic interventions.
| Τίτλος: | Cellular senescence in ischemic stroke: Cell-type specificity, temporal dynamics, and response to therapeutic interventions. |
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| Συγγραφείς: | Liu X; Department of Neurology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Guo Y; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Popa-Wagner A; Center for Normal and Pathological Ageing, University of Medicine and Pharmacy, Craiova, Romania., Lämmermann I; Rockfish Bio AG, Vienna, Austria., Grillari J; Ludwig Boltzmann Institute for Traumatology, the Research Center in Cooperation with AUVA, Vienna, Austria; Institute of Molecular Biotechnology, BOKU University, Vienna, Austria; Austrian Cluster for Tissue Regeneration, Vienna, Austria. Electronic address: johannes.grillari@boku.ac.at., Hermann DM; Department of Neurology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. Electronic address: dirk.hermann@uk-essen.de. |
| Πηγή: | Ageing research reviews [Ageing Res Rev] 2026 Aug; Vol. 120, pp. 103206. Date of Electronic Publication: 2026 Jun 14. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Science Country of Publication: England NLM ID: 101128963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9649 (Electronic) Linking ISSN: 15681637 NLM ISO Abbreviation: Ageing Res Rev Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Oxford, UK : Elsevier Science, c2002- |
| Ιατρικοί όροι (MeSH): | Cellular Senescence*/physiology , Ischemic Stroke*/pathology , Ischemic Stroke*/metabolism , Ischemic Stroke*/therapy , Brain*/pathology , Brain*/metabolism , Brain Ischemia*/pathology , Stroke*/pathology, Humans ; Animals ; Senescence-Associated Secretory Phenotype |
| Περίληψη: | Increasing experimental and clinical evidence indicates activation of cellular programs resembling senescence and senescence-associated secretory phenotype signaling after stroke. However, a central challenge is definitional: in injured brain tissue, many senescence-associated features overlap with acute stress responses, transient cell-cycle perturbations, and reactive glial or vascular programs, complicating interpretation across models, time points, and cell types. Here, we synthesize the literature using a cell-type-resolved framework spanning acute, subacute, and chronic stroke phases across major neurovascular and immune compartments. Rather than treating senescence as a binary fate, we conceptualize post-stroke senescence-associated biology as a dynamic continuum, in which ischemia-reperfusion stress engages multiple senescence-related domains, only a subset of which may stabilize into durable cell senescence. Accordingly, we emphasize convergent multi-domain evidence with spatial and cell identity resolution, and cautious use of the term "senescence-like" during early injury. Finally, we discuss translational implications through a timing- and safety-aware perspective, arguing that modulation of maladaptive secretory outputs may be superior to cell-elimination strategies in early post-stroke windows. We highlight key biological and clinical uncertainties-including blood-brain barrier dynamics, hemorrhagic and infectious risk, and interference with endogenous repair-that define critical risk gates for evaluating senescence-targeting approaches after stroke. (Copyright © 2026 The Authors. Published by Elsevier B.V. All rights reserved.) |
| Competing Interests: | Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Cellular senescence; Ischemic stroke; Neurovascular unit; Senescence-associated secretory phenotype; Temporal dynamics; Therapeutic window |
| Entry Date(s): | Date Created: 20260614 Date Completed: 20260708 Latest Revision: 20260708 |
| Update Code: | 20260708 |
| DOI: | 10.1016/j.arr.2026.103206 |
| PMID: | 42289192 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1872-9649 |
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| DOI: | 10.1016/j.arr.2026.103206 |