Reframing nociplastic pain research and treatment using post-traumatic stress disorder-inspired conceptual models.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος:	Reframing nociplastic pain research and treatment using post-traumatic stress disorder-inspired conceptual models.
Συγγραφείς:	Coulombe-Leveque A; École de réadaptation, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, QC, Canada.; Centre de recherche sur le vieillissement, CIUSSS de l'Estrie-CHUS, Université de Sherbrooke, Sherbrooke, QC, Canada., Bonin RP; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada.; University of Toronto Centre for the Study of Pain, University of Toronto, Toronto, ON, Canada., Léonard G; École de réadaptation, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, QC, Canada.; Centre de recherche sur le vieillissement, CIUSSS de l'Estrie-CHUS, Université de Sherbrooke, Sherbrooke, QC, Canada.
Πηγή:	Pain [Pain] 2026 Aug 01; Vol. 167 (8), pp. 1745-1757. Date of Electronic Publication: 2026 Jun 09.
Τύπος έκδοσης:	Journal Article; Review
Γλώσσα:	English
Στοιχεία περιοδικού:	Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 7508686 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6623 (Electronic) Linking ISSN: 03043959 NLM ISO Abbreviation: Pain Subsets: MEDLINE
Imprint Name(s):	Publication: 2015- : Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: Amsterdam, Elsevier/North-Holland.
Ιατρικοί όροι (MeSH):	Nociplastic Pain/therapy , Nociplastic Pain/physiopathology , Stress Disorders, Post-Traumatic/physiopathology , Stress Disorders, Post-Traumatic/therapy , Stress Disorders, Post-Traumatic/psychology , Pain Management/methods , Chronic Pain/physiopathology , Chronic Pain/therapy, Humans ; Animals
Περίληψη:	Abstract: Pain and fear are aversive alarm signals that serve adaptive protective functions. Pathologically disproportionate fear or pain responses can lead to conditions such as post-traumatic stress disorder (PTSD) or chronic pain. Although they are distinct conditions, PTSD and chronic pain-particularly nociplastic pain-share common risk factors, vulnerability, and exhibit mutual maintenance. Moreover, there exist similarities in the clinical presentation and neurophysiology of PTSD and nociplastic pain that suggest a shared underlying pathophysiology. In this article, we review functional changes that occur in the brain in both conditions to demonstrate parallels between PTSD and nociplastic pain and specifically highlight the role of the amygdala. We argue that differences in a priori conceptual models of these disorders may have influenced research approaches and interpretations that reinforce the current division between PTSD and nociplastic pain, and propose that insights from the study of PTSD can be used to guide pain research and treatment. We suggest the development and use of PTSD-inspired conceptual models of pain to generate testable hypotheses for fundamental and clinical pain research. Finally, we illustrate possible clinical benefits of using PTSD-inspired models for the treatment of nociplastic pain by discussing reconsolidation therapy, a treatment for PTSD whose mechanism of action could also make it a plausible treatment for nociplastic pain. (Copyright © 2026 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the International Association for the Study of Pain.)
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Grant Information:	Fellowship Canada CAPMC CIHR; Chair in Sensory Plasticity - Tier II Canada Research Chairs; Chercheur boursier - sénior Fonds de Recherche du Québec - Santé
Contributed Indexing:	Keywords: Amygdala; Chronic pain; Nociplastic pain; Reconsolidation; post-traumatic stress disorder
Entry Date(s):	Date Created: 20260614 Date Completed: 20260720 Latest Revision: 20260726
Update Code:	20260726
PubMed Central ID:	PMC13382873
DOI:	10.1097/j.pain.0000000000004013
PMID:	42289101
Βάση Δεδομένων:	MEDLINE

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ISSN:	1872-6623
DOI:	10.1097/j.pain.0000000000004013