Academic Journal
Real-world evidence from a prospective longitudinal cohort study assessing changes in smoking behavior among adults using NJOY ACE tobacco and menthol ENDS products.
| Τίτλος: | Real-world evidence from a prospective longitudinal cohort study assessing changes in smoking behavior among adults using NJOY ACE tobacco and menthol ENDS products. |
|---|---|
| Συγγραφείς: | Vergara K; Altria Client Services, 6601 W. Broad Street, Richmond, VA 23230, United States. Electronic address: Katherine.Vergara@altria.com., Pope DA; Altria Client Services, 6601 W. Broad Street, Richmond, VA 23230, United States., Sarkar M; Altria Client Services, 6601 W. Broad Street, Richmond, VA 23230, United States. |
| Πηγή: | Drug and alcohol dependence [Drug Alcohol Depend] 2026 Aug 01; Vol. 285, pp. 113223. Date of Electronic Publication: 2026 May 29. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: Ireland NLM ID: 7513587 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0046 (Electronic) Linking ISSN: 03768716 NLM ISO Abbreviation: Drug Alcohol Depend Subsets: MEDLINE |
| Imprint Name(s): | Publication: Limerick : Elsevier Original Publication: Lausanne, Elsevier Sequoia. |
| Ιατρικοί όροι (MeSH): | Electronic Nicotine Delivery Systems*/statistics & numerical data , Smoking*/epidemiology , Smoking*/psychology , Menthol* , Smoking Cessation* , Tobacco Products*, Humans ; Female ; Longitudinal Studies ; Male ; Adult ; Prospective Studies ; Middle Aged ; Young Adult |
| Περίληψη: | Background: Switching from cigarettes to electronic nicotine delivery systems (ENDS) has the potential to reduce smoking-related harm among adults who smoke (AS). Actual use behavior under real-world conditions can inform the substitution potential of ENDS products. The objective of this study was to assess the transition patterns from combustible cigarettes to use of NJOY ACE® ENDS products. Methods: We conducted a prospective longitudinal cohort study (LCS) in a national, purposive sample of 8002 US adults, identity- and age-verified 21 + years, who first used NJOY ACE within the 12-month period prior to Baseline. Participants completed online surveys at Baseline and at 1-, 2-, 3- and 6-month follow-ups. Survey items included demographic characteristics, tobacco product use, and other outcome measures. Adjusted logistic regressions (controlling for relevant covariates) were applied to multiple analytic cohorts - per-protocol (PP) and intent-to-treat (ITT) - to comprehensively determine the association between tobacco and menthol-flavored NJOY ACE use and the association between flavor and past 30-day point prevalence smoking abstinence (30dPPA). Results: Overall PP/ITT switching rates (30dPPA) among participants who used tobacco or menthol flavored product at the 3- and 6-month time points were 22.0%/15.1% and 36.2%/23.6%, respectively. Menthol-flavored product use was associated with significantly higher switching rates than tobacco-flavored use across the different analytic cohorts (1.12-1.55x higher). Covariate-adjusted logistic regressions demonstrated consistently higher odds of 3-month 30dPPA (Odds Ratio = 1.33-1.50) for menthol- compared to tobacco-flavored products. Conclusions: Real-world data demonstrated that availability of NJOY ACE results in robust switching from cigarettes and therefore can manifest a public health benefit. (Copyright © 2026. Published by Elsevier B.V.) |
| Competing Interests: | Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Katherine Vergara reports financial support was provided by NJOY LLC. Derek Pope reports financial support was provided by Fox Foundation. Katherine Vergara reports a relationship with NJOY LLC that includes: employment and equity or stocks. Derek Pope reports a relationship with Fox Foundation that includes: employment. All authors are employees of Altria Client Services, LLC. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper |
| Contributed Indexing: | Keywords: APPH; Complete switch; ENDS; Harm reduction; NJOY |
| Substance Nomenclature: | 1490-04-6 (Menthol) |
| Entry Date(s): | Date Created: 20260611 Date Completed: 20260627 Latest Revision: 20260627 |
| Update Code: | 20260628 |
| DOI: | 10.1016/j.drugalcdep.2026.113223 |
| PMID: | 42275902 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1879-0046 |
|---|---|
| DOI: | 10.1016/j.drugalcdep.2026.113223 |