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Beyond the Glands: Extraglandular Manifestations Associated With Sicca Symptoms in Systemic Sclerosis.

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Τίτλος: Beyond the Glands: Extraglandular Manifestations Associated With Sicca Symptoms in Systemic Sclerosis.
Συγγραφείς: Koletsos N; Department of Rheumatology, School of Health Sciences, Faculty of Medicine, University of Ioannina, Ioannina, Greece., Trentzidis K; Radiology Department, Theageneio Anticancer Hospital, Thessaloniki, Greece., Gerolymatou N; Department of Rheumatology, School of Health Sciences, Faculty of Medicine, University of Ioannina, Ioannina, Greece., Drosos AA; Department of Rheumatology, School of Health Sciences, Faculty of Medicine, University of Ioannina, Ioannina, Greece., Voulgari PV; Department of Rheumatology, School of Health Sciences, Faculty of Medicine, University of Ioannina, Ioannina, Greece.
Πηγή: Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases [J Clin Rheumatol] 2026 Oct 01; Vol. 32 (7), pp. 212-216. Date of Electronic Publication: 2026 Jun 09.
Τύπος έκδοσης: Journal Article; Observational Study
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9518034 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-7355 (Electronic) Linking ISSN: 10761608 NLM ISO Abbreviation: J Clin Rheumatol Subsets: MEDLINE
Imprint Name(s): Publication: Philadelphia, PA : Lippincott Williams & Wilkins
Original Publication: Baltimore, MD : Williams & Wilkins, c1995-
Ιατρικοί όροι (MeSH): Scleroderma, Systemic*/complications , Scleroderma, Systemic*/physiopathology , Scleroderma, Systemic*/diagnosis , Sjogren's Syndrome*/diagnosis , Sjogren's Syndrome*/etiology , Sjogren's Syndrome*/epidemiology , Xerostomia*/etiology , Xerostomia*/diagnosis , Xerostomia*/epidemiology , Dry Eye Syndromes*/etiology , Dry Eye Syndromes*/epidemiology , Dry Eye Syndromes*/diagnosis, Humans ; Female ; Middle Aged ; Male ; Retrospective Studies ; Aged
Περίληψη: Background/objective: Sicca symptoms, including ocular and oral dryness, are frequently reported among patients with systemic sclerosis (SSc). Yet most studies have focused on patients with associated Sjögren disease (SjD) and data on SSc patients with isolated sicca symptoms remain limited. Therefore, we aimed to (i) investigate the characteristics of SSc patients with and without sicca symptoms, after excluding individuals with associated SjD or other potential causes of dryness, and (ii) identify factors independently associated with the presence of sicca manifestations.
Materials and Methods: This single-center retrospective observational study included consecutive SSc patients attending the Department until December 2024. Demographic, clinical and serological data were extracted from medical records. Sicca symptoms were defined as the presence of either dry eye or dry mouth symptoms documented in the medical records, using a structured approach. Multivariable logistic regression analysis was performed to determine variables significantly associated with sicca symptoms.
Results: In total, 237 SSc patients were included, 25.7% of whom reported sicca symptoms. In univariate analysis, age, female sex, arthralgias, left ventricular diastolic dysfunction (LVDD), and ratio of residual volume to total lung capacity (RV/TLC) ≥40% were associated with sicca symptoms. In multivariate analysis, only female sex [OR: 4.808 (95% CI: 1.088-15.308)] and RV/TLC≥40% [OR: 4.413 (95% CI: 1.982-9.826)] remained independent predictors of sicca manifestations.
Conclusion: Sicca symptoms are common in SSc, even in the absence of SjD, and are characterized by female predominance and small airway involvement. SSc patients with isolated sicca symptoms may represent a distinct clinical phenotype.
(Copyright © 2026 Wolters Kluwer Health, LLC. All rights reserved.)
Competing Interests: The authors declare no conflicts of interest.
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Contributed Indexing: Keywords: Sjögren disease; sicca; small airway disease; systemic sclerosis
Entry Date(s): Date Created: 20260611 Date Completed: 20260929 Latest Revision: 20260929
Update Code: 20260929
DOI: 10.1097/RHU.0000000000002378
PMID: 42275177
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1536-7355
DOI:10.1097/RHU.0000000000002378