Academic Journal
Verification and validation in canine cadaver of an MPI-integrable RF head coil for magnetic particle hyperthermia.
| Τίτλος: | Verification and validation in canine cadaver of an MPI-integrable RF head coil for magnetic particle hyperthermia. |
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| Συγγραφείς: | Carlton H; Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA., Mattingly E; Magnetic Insight, Alameda, CA, USA., Mohtasebzadeh AR; Magnetic Insight, Alameda, CA, USA., Lad YS; Department of Mechanical Engineering, School of Science, Engineering, and Technology, The Pennsylvania State University-Harrisburg, Middletown, PA, USA., Pawar S; Department of Mechanical Engineering, School of Science, Engineering, and Technology, The Pennsylvania State University-Harrisburg, Middletown, PA, USA., Attaluri A; Department of Mechanical Engineering, School of Science, Engineering, and Technology, The Pennsylvania State University-Harrisburg, Middletown, PA, USA., Kraitchman D; Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Department of Molecular and Comparative Pathobiology, Johns Hopkins School of Medicine, Baltimore, MD, USA:., Ivkov R; Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Department of Oncology, Sydney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.; Department of Mechanical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.; Department of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA., Goodwill P; Magnetic Insight, Alameda, CA, USA. |
| Πηγή: | International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group [Int J Hyperthermia] 2026 Dec; Vol. 43 (1), pp. 2672017. Date of Electronic Publication: 2026 Jun 10. |
| Τύπος έκδοσης: | Journal Article; Research Support, N.I.H., Extramural |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 8508395 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-5157 (Electronic) Linking ISSN: 02656736 NLM ISO Abbreviation: Int J Hyperthermia Subsets: MEDLINE |
| Imprint Name(s): | Publication: London : Informa Healthcare Original Publication: London ; Philadelphia : Taylor & Francis, c1985- |
| Ιατρικοί όροι (MeSH): | Hyperthermia, Induced*/methods , Magnetic Particle Imaging*/methods , Magnetite Nanoparticles*/therapeutic use, Animals ; Dogs ; Humans ; Cadaver |
| Περίληψη: | Purpose: Magnetic particle hyperthermia (MPH), the mild heating of solid tumors with magnetic nanoparticles, is an emerging treatment modality used as an adjuvant to therapies such as ionizing radiation. MPH can be paired with magnetic particle imaging (MPI) hardware to improve thermal treatment planning, spatially confined heating, and thermal dose delivery. In this work, we describe the design, verification, and validation of a radiofrequency (RF) head coil designed to integrate into a clinical MPI scanner. Methods: The RF coil was designed to accommodate an adult human head, provide a homogeneous (±10%) field along a 10 cm axial centerline, generate a peak magnetic flux density of 10 mT at 100 kHz, and be MPI compliant. Verification of the design consisted of a combination of magnetic field and nanoparticle heating measurements. To validate an MPI/MPH imaging and heating workflow, a canine cadaver was surgically prepared by implanting magnetic nanoparticles in the brain, followed by anatomical imaging, MPI, and heating with the head coil. To explore if the measured performance can be generalized to human treatment, we conducted a virtual MPH treatment of a human glioma. Results: Coil performance verification demonstrated RF fields as high as INLINEMATH mT at 100.4 kHz, while achieving hyperthermic temperatures in tumor phantoms. The MPI scan of the canine cadaver head revealed differences in signal intensity between particle injection sites, which correlated with temperature increases measured during heating. Computational simulation of a human head showcased the feasibility of this system to treat gliomas. Conclusions: We successfully constructed, verified, and validated an MPI-compatible RF head coil for combined MPI/MPH therapy. |
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| Grant Information: | R01 CA247290 United States CA NCI NIH HHS; R01 CA257557 United States CA NCI NIH HHS; R44 CA285064 United States CA NCI NIH HHS; 1R44 CA306682 United States NH NIH HHS |
| Contributed Indexing: | Keywords: Magnetic particle hyperthermia; RF coil design; design verification and validation; image guided; magnetic particle imaging |
| Substance Nomenclature: | 0 (Magnetite Nanoparticles) |
| Entry Date(s): | Date Created: 20260610 Date Completed: 20260611 Latest Revision: 20260905 |
| Update Code: | 20260905 |
| PubMed Central ID: | PMC13541239 |
| DOI: | 10.1080/02656736.2026.2672017 |
| PMID: | 42270409 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1464-5157 |
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| DOI: | 10.1080/02656736.2026.2672017 |