Academic Journal
Corylin promotes healthy aging via RAGA-mTOR suppression and sex-dependent activation of SIRT3.
| Τίτλος: | Corylin promotes healthy aging via RAGA-mTOR suppression and sex-dependent activation of SIRT3. |
|---|---|
| Συγγραφείς: | Cheng SF; Graduate Institute of Natural Products, Chang Gung University, Taoyuan, Taiwan, ROC., Lin YT; Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan, ROC., Wang TH; Graduate Institute of Natural Products, Chang Gung University, Taoyuan, Taiwan, ROC.; Biobank, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC.; Department of Hepato-Gastroenterology, Liver Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC.; Graduate Institute of Health Industry Technology and Research Center for Food and Cosmetic Safety, Chang Gung University of Science and Technology, Taoyuan, Taiwan, ROC., Leu YL; Graduate Institute of Natural Products, Chang Gung University, Taoyuan, Taiwan, ROC.; Biobank, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC., Hsia KC; Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, ROC., Lee WC; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan, ROC.; Institute of Biomedical Science, Academia Sinica, Taipei, Taiwan, ROC., Feng CH; Graduate Institute of Natural Products, Chang Gung University, Taoyuan, Taiwan, ROC., Kuo CH; Institute of Biomedical Science, Academia Sinica, Taipei, Taiwan, ROC., Yang SH; School of Traditional Chinese Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.; Division of Chinese Internal Medicine, Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC., Wang MC; School of Traditional Chinese Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.; Division of Chinese Gynecology Medicine, Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC., Liu CY; Graduate Institute of Natural Products, Chang Gung University, Taoyuan, Taiwan, ROC., Hu PC; Graduate Institute of Natural Products, Chang Gung University, Taoyuan, Taiwan, ROC., Hsieh YC; Office of the Texas State Chemist, AgriLife Research, Texas A&M University System, College Station, TX, USA., Yang CW; Department of Nephrology and Kidney Research Center, School of Medicine, Chang Gung University, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC., Wang SH; Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC., Yu JS; Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan, ROC. yusong@mail.cgu.edu.tw.; Department of Otolaryngology-Head & Neck Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC. yusong@mail.cgu.edu.tw.; Research Center for Food and Cosmetic Safety, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan, ROC. yusong@mail.cgu.edu.tw., Chen CY; Biobank, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC. cychen@mail.cgust.edu.tw.; Graduate Institute of Health Industry Technology and Research Center for Food and Cosmetic Safety, Chang Gung University of Science and Technology, Taoyuan, Taiwan, ROC. cychen@mail.cgust.edu.tw., Chen CC; Graduate Institute of Natural Products, Chang Gung University, Taoyuan, Taiwan, ROC. chinchuan@mail.cgu.edu.tw.; Biobank, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC. chinchuan@mail.cgu.edu.tw. |
| Πηγή: | Nature communications [Nat Commun] 2026 Jun 10; Vol. 17 (1). Date of Electronic Publication: 2026 Jun 10. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [London] : Nature Pub. Group |
| Ιατρικοί όροι (MeSH): | TOR Serine-Threonine Kinases*/metabolism , TOR Serine-Threonine Kinases*/genetics , Sirtuin 3*/metabolism , Sirtuin 3*/genetics , Flavonoids*/pharmacology , Healthy Aging*/drug effects , Monomeric GTP-Binding Proteins*/metabolism , Monomeric GTP-Binding Proteins*/genetics, Longevity/drug effects ; Signal Transduction/drug effects ; Animals ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Sex Factors |
| Περίληψη: | Aging is accompanied by progressive physiological decline and an increased risk of chronic disease, motivating the search for interventions that promote healthy longevity. We found that mid-life administration of Corylin, a flavonoid derived from Psoralea corylifolia, improves metabolic function, muscle integrity, and physical performance in mice maintained on a standard diet. Corylin significantly extends median lifespan in female mice, with an 11.9% increase and a 33% higher survival rate at 125 weeks, whereas no comparable benefit is observed in males. Here, we show that integrated multi-omics analyses across multiple tissues reveal coordinated age-associated molecular changes modulated by Corylin. These analyses link Corylin treatment to suppression of mechanistic target of rapamycin signaling, which is further supported by direct interaction between Corylin and Ras-related GTP-binding protein A. In addition, Corylin restores sirtuin 3 protein levels and energy-associated metabolic programs in female mice, providing mechanistic insight into sex-dependent longevity benefits. (© 2026. The Author(s).) |
| Competing Interests: | Competing interests: S.-F.C., C.-C.C., Y.-L.L., and T.-H.W. are listed as inventors on a granted patent (Taiwan Patent No. I832408) related to the use of compounds for anti-aging applications. The patent is not based on the data or animal models described in this study. All other authors declare no competing interests. |
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| Grant Information: | CMRPD1M0591-3 Chang Gung Memorial Hospital (CGMH) |
| Molecular Sequence: | GEO GSE305103 BioProject PRJNA1302561 PDB 1A52; 6S6A; 2Q3F |
| Substance Nomenclature: | EC 2.7.11.1 (TOR Serine-Threonine Kinases) EC 3.5.1.- (Sirtuin 3) 0 (Flavonoids) EC 2.7.1.1 (mTOR protein, mouse) EC 3.6.5.2 (Monomeric GTP-Binding Proteins) 0 (Sirt3 protein, mouse) |
| Entry Date(s): | Date Created: 20260609 Date Completed: 20260726 Latest Revision: 20260729 |
| Update Code: | 20260730 |
| PubMed Central ID: | PMC13402637 |
| DOI: | 10.1038/s41467-026-74184-9 |
| PMID: | 42265126 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2041-1723 |
|---|---|
| DOI: | 10.1038/s41467-026-74184-9 |