Academic Journal
The skin microbiome as a key regulator of psoriasis: From dysbiotic drivers to host-directed therapeutics.
| Τίτλος: | The skin microbiome as a key regulator of psoriasis: From dysbiotic drivers to host-directed therapeutics. |
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| Συγγραφείς: | Xie T; Department of Dermatology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical college, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China; Department of Dermatology, Wuhan No.1 Hospital, Wuhan, Hubei 430022, China; Hubei Province & Key Laboratory of Skin Infection and Immunity, Wuhan, Hubei 430022, China., Hao Y; Department of Infection Control, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Electronic address: yhhao@tjh.tjmu.edu.cn., Qin L; Department of Dermatology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical college, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China; Department of Dermatology, Wuhan No.1 Hospital, Wuhan, Hubei 430022, China; Hubei Province & Key Laboratory of Skin Infection and Immunity, Wuhan, Hubei 430022, China. Electronic address: liqin_hust@hust.edu.cn. |
| Πηγή: | Microbiological research [Microbiol Res] 2026 Oct; Vol. 311, pp. 128577. Date of Electronic Publication: 2026 Jun 07. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: G. Fischer Country of Publication: Germany NLM ID: 9437794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-0623 (Electronic) Linking ISSN: 09445013 NLM ISO Abbreviation: Microbiol Res Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Jena : G. Fischer, c1994- |
| Ιατρικοί όροι (MeSH): | Psoriasis*/microbiology , Psoriasis*/therapy , Psoriasis*/immunology , Dysbiosis*/microbiology , Skin*/microbiology , Skin Microbiome* , Microbiota*, Humans ; Host-Directed Therapy ; Animals ; Host Microbial Interactions |
| Περίληψη: | The skin harbors diverse microbial communities. Compared with gut microbiome dysbiosis, perturbations in the skin microbiome may be more directly implicated in the onset and progression of psoriasis (PSO). More than twenty studies reveal microbial dysbiosis within psoriatic lesions, which is manifested by elevated abundances of pro-inflammatory taxa such as Corynebacterium and Staphylococcus aureus, declined levels of commensal microbes including Cutibacterium, increased total bacterial load and decreased microbial community diversity. Such cutaneous microbial dysbiosis accelerates disease progression via multiple biological pathways, involving impairment of the skin barrier, dysregulation of the innate and adaptive immunity, as well as multifaceted biological effects mediated by microbial metabolites. Microbiome-based diagnostic strategies have emerged as novel tools for evaluating disease prognosis, and targeted modulation of the skin microbiome holds promising prospects for clinical translation. In-depth exploration of skin microbial signatures in PSO enables the skin microbiome to serve as clinically valuable biomarkers for predicting subtype transformation and disease progression and fluctuation. Future research priorities lie in the integration of multi-omics strategies to dissect the potential causal mechanisms underlying host-microbe crosstalk, establish optimized bioengineering techniques and further promote the advancement of individualized therapeutic regimens. Collectively, the skin microbiome not only sheds new light on the pathogenic mechanisms of PSO, but also identifies promising candidate targets for auxiliary diagnosis and precise microbiome-based therapeutic interventions. (Copyright © 2026 Elsevier GmbH. All rights reserved.) |
| Contributed Indexing: | Keywords: Psoriasis; Skin microbiome |
| Entry Date(s): | Date Created: 20260609 Date Completed: 20260711 Latest Revision: 20260711 |
| Update Code: | 20260712 |
| DOI: | 10.1016/j.micres.2026.128577 |
| PMID: | 42263474 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1618-0623 |
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| DOI: | 10.1016/j.micres.2026.128577 |