Academic Journal
The impact of upper gastrointestinal disorders on frailty: insights from the Baltimore Longitudinal Study of Aging.
| Τίτλος: | The impact of upper gastrointestinal disorders on frailty: insights from the Baltimore Longitudinal Study of Aging. |
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| Συγγραφείς: | Tegegne BS; Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging Intramural Program, National Institutes of Health, Baltimore, Maryland, United States., Gupta T; Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States., Ferrucci L; Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging Intramural Program, National Institutes of Health, Baltimore, Maryland, United States., Tanaka T; Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging Intramural Program, National Institutes of Health, Baltimore, Maryland, United States. |
| Πηγή: | The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2026 Jun 06; Vol. 81 (7). |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: published on behalf of the Gerontological Society of America by Oxford University Press Country of Publication: United States NLM ID: 9502837 Publication Model: Print Cited Medium: Internet ISSN: 1758-535X (Electronic) Linking ISSN: 10795006 NLM ISO Abbreviation: J Gerontol A Biol Sci Med Sci Subsets: MEDLINE |
| Imprint Name(s): | Publication: Washington, DC : published on behalf of the Gerontological Society of America by Oxford University Press Original Publication: Washington, DC : Gerontological Society of America, c1995- |
| Ιατρικοί όροι (MeSH): | Frailty*/epidemiology , Frailty*/etiology , Gastrointestinal Diseases*/complications , Gastrointestinal Diseases*/epidemiology , Aging* , Frail Elderly*, Baltimore/epidemiology ; Humans ; Female ; Male ; Aged ; Longitudinal Studies ; Cross-Sectional Studies ; Middle Aged ; Body Mass Index |
| Περίληψη: | Background: Upper gastrointestinal (GI) disorders-including gastroesophageal reflux disorder, peptic ulcer disease, and gastritis-are common with aging, yet their contribution to frailty burden and progression is poorly understood. This study investigated whether upper GI disorders are independently associated with frailty in the Baltimore Longitudinal Study of Aging. Methods: We analyzed data from 1353 participants (mean age 65.6 years; 47.7% men) with documented upper GI disorder status and Frailty Index (FI). Cross-sectional associations were examined using linear regression adjusted for age, sex, race, education, body mass index (BMI), and smoking. Longitudinal trajectories of FI were analyzed in a subset with ≥3 follow-up visits (n = 749) using linear mixed-effects models. Sensitivity analyses were conducted after excluding participants whose diagnosis occurred more than 1 year before FI assessment and for older adults. Results: Upper GI disorders were significantly associated with higher frailty burden in cross-sectional analyses (β = 0.0303, p = 1.13 × 10-11). Older age, higher BMI, and lower educational attainment were also associated with higher FI. Longitudinal analyses further demonstrated that upper GI disorders were a significant predictor of FI throughout the follow-up period (β = 0.018, p = 4.3 × 10-9). However, the rate of frailty progression did not differ significantly between participants with and without GI disorders. Associations remained robust in all sensitivity analyses. Conclusions: Upper GI disorders were associated with higher frailty burden and greater degree of frailty that persisted over time, independent of covariates. Further research may be needed to explore the specific mechanisms through which upper GI disorders influence frailty. (Published by Oxford University Press on behalf of the Gerontological Society of America 2026.) |
| Grant Information: | Intramural Research Program of the National Institutes of Health |
| Contributed Indexing: | Keywords: BLSA; Frailty Index; Longitudinal analysis; Upper gastrointestinal disorders |
| Entry Date(s): | Date Created: 20260609 Date Completed: 20260623 Latest Revision: 20260624 |
| Update Code: | 20260624 |
| DOI: | 10.1093/gerona/glag148 |
| PMID: | 42262909 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1758-535X |
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| DOI: | 10.1093/gerona/glag148 |